Pan-cancer antagonistic inhibition pattern of ATM-driven G2/M checkpoint pathway vs other DNA repair pathways.

Autor: Zolotovskaia MA; Laboratory for Translational Genomic Bioinformatics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russia; Omicsway Corp., Walnut, CA, 91789, USA. Electronic address: zolotovskaia.ma@mipt.ru., Modestov AA; Laboratory for Translational Genomic Bioinformatics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russia; Laboratory for Clinical and Genomic Bioinformatics, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia., Suntsova MV; Laboratory for Translational Genomic Bioinformatics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russia; World-Class Research Center 'Digital biodesign and personalized healthcare', Sechenov First Moscow State Medical University, Moscow, Russia., Rachkova AA; Laboratory for Translational Genomic Bioinformatics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russia; Laboratory for Clinical and Genomic Bioinformatics, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia., Koroleva EV; Laboratory for Translational Genomic Bioinformatics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russia., Poddubskaya EV; Laboratory for Clinical and Genomic Bioinformatics, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia., Sekacheva MI; Laboratory for Clinical and Genomic Bioinformatics, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia., Tkachev VS; Oncobox Ltd., Moscow 121205, Russia., Garazha AV; Omicsway Corp., Walnut, CA, 91789, USA; Oncobox Ltd., Moscow 121205, Russia., Glusker AA; Laboratory for Clinical and Genomic Bioinformatics, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia., Seryakov AP; Department of Oncology, Medical Holding SM-Clinic, 105120 Moscow, Russia., Vladimirova US; Laboratory for Clinical and Genomic Bioinformatics, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia., Rumiantsev PO; Department of Nuclear Medicine, Endocrinology Research Centre, Moscow 117312, Russia., Moisseev AA; Laboratory for Clinical and Genomic Bioinformatics, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia., Zharkov DO; Laboratory for Protein Engineering, Novosibirsk State University, Novosibirsk 630090, Russia; Laboratory for Genomic and Protein Engineering, SB RAS Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia., Kuzmin DV; Laboratory for Translational Genomic Bioinformatics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russia., Zhao X; Core Laboratory, The Affiliated Qingdao Central Hospital of Qingdao University, Qingdao 266042 China., Prassolov VS; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia., Shegay PV; National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia., Li X; UCLA Technology Center for Genomics & Bioinformatics, Department of Pathology & Laboratory Medicine, Los Angeles, CA 90095, USA., Steinbichler TB; Tyrolean Cancer Research Institute, Innsbruck, Austria., Kim E; Clinic for Neurosurgery, Laboratory of Experimental Neurooncology, Johannes Gutenberg University Medical Centre, Langenbeckstrasse 1, 55124 Mainz, Germany., Sorokin MI; Laboratory for Translational Genomic Bioinformatics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russia; Omicsway Corp., Walnut, CA, 91789, USA; Laboratory for Clinical and Genomic Bioinformatics, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia; Laboratory for Genomic Analysis of Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia., Wang Y; Core Laboratory, The Affiliated Qingdao Central Hospital of Qingdao University, Qingdao 266042 China. Electronic address: yewang@qdu.edu.cn., Buzdin AA; Laboratory for Translational Genomic Bioinformatics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russia; World-Class Research Center 'Digital biodesign and personalized healthcare', Sechenov First Moscow State Medical University, Moscow, Russia; Laboratory for Genomic Analysis of Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia; PathoBiology Group, European Organization for Research and Treatment of Cancer (EORTC), Brussels, Belgium.

Publikováno v: DNA repair [DNA Repair (Amst)] 2023 Mar; Vol. 123, pp. 103448. Date of Electronic Publication: 2023 Jan 13.

Disparity between Inter-Patient Molecular Heterogeneity and Repertoires of Target Drugs Used for Different Types of Cancer in Clinical Oncology.

Autor: Zolotovskaia MA; Oncobox ltd., Moscow 121205, Russia.; Department of Oncology, Hematology and Radiotherapy of Pediatric Faculty, Pirogov Russian National Research Medical University, Moscow 117997, Russia.; Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russia., Sorokin MI; I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia.; Omicsway Corp., Walnut, CA, 91789, USA.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia., Petrov IV; Oncobox ltd., Moscow 121205, Russia., Poddubskaya EV; I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia., Moiseev AA; I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia., Sekacheva MI; I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia., Borisov NM; Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russia.; I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia.; Omicsway Corp., Walnut, CA, 91789, USA., Tkachev VS; Omicsway Corp., Walnut, CA, 91789, USA., Garazha AV; Omicsway Corp., Walnut, CA, 91789, USA., Kaprin AD; National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow 125284, Russia., Shegay PV; Center for Innovative Radiological and Regenerative Technologies of the Ministry of Health of the Russian Federation, Obninsk 249030, Russia., Giese A; Orthocentrum Hamburg, 20149 Hamburg, Germany., Kim E; Johannes Gutenberg University Mainz, Mainz, Germany., Roumiantsev SA; Department of Oncology, Hematology and Radiotherapy of Pediatric Faculty, Pirogov Russian National Research Medical University, Moscow 117997, Russia., Buzdin AA; Oncobox ltd., Moscow 121205, Russia.; Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russia.; I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2020 Feb 26; Vol. 21 (5). Date of Electronic Publication: 2020 Feb 26.

Potentialities of MicroRNA Diagnosis in Patients with Bladder Cancer.

Autor: Shegay PV; National Medical Radiological Research Center, Ministry of Health of the Russian Federation, Moscow, Russia. dr.shegay@mail.ru., Zhavoronkov AA; First Oncology Research and Advisory Center (FORAC), Moscow, Russia., Gaifullin NM; M. V. Lomonosov Moscow State University, Moscow, Russia., Vorob'ev NV; National Medical Radiological Research Center, Ministry of Health of the Russian Federation, Moscow, Russia., Alekseev BY; National Medical Radiological Research Center, Ministry of Health of the Russian Federation, Moscow, Russia., Popov SV; National Medical Radiological Research Center, Ministry of Health of the Russian Federation, Moscow, Russia., Garazha AV; First Oncology Research and Advisory Center (FORAC), Moscow, Russia., Buzdin AA; First Oncology Research and Advisory Center (FORAC), Moscow, Russia., Kaprin AD; National Medical Radiological Research Center, Ministry of Health of the Russian Federation, Moscow, Russia.

Publikováno v: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Nov; Vol. 164 (1), pp. 106-108. Date of Electronic Publication: 2017 Nov 09.

Early stage of cytomegalovirus infection suppresses host microRNA expression regulation in human fibroblasts.

Autor: Buzdin AA; a Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology , Moscow , Russia.; b Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Moscow , Russia.; c National Research Centre 'Kurchatov Institute', Centre for Convergence of Nano-, Bio-, Information and Cognitive Sciences and Technologies , Moscow , Russia., Artcibasova AV; a Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology , Moscow , Russia.; d Pathway Pharmaceuticals , Wan Chai, Hong Kong , Hong Kong SAR., Fedorova NF; e N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology of the Ministry of Health of the Russian Federation , Moscow , Russia., Suntsova MV; a Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology , Moscow , Russia.; b Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Moscow , Russia., Garazha AV; a Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology , Moscow , Russia.; f Moscow Institute of Physics and Technology , Dolgoprudny, Moscow region , Russia., Sorokin MI; g First Oncology Research and Advisory Center , Moscow , Russia., Allina D; f Moscow Institute of Physics and Technology , Dolgoprudny, Moscow region , Russia.; g First Oncology Research and Advisory Center , Moscow , Russia., Shalatonin M; h The Morozov Children's City Hospital , Moscow Russia., Borisov NM; c National Research Centre 'Kurchatov Institute', Centre for Convergence of Nano-, Bio-, Information and Cognitive Sciences and Technologies , Moscow , Russia.; g First Oncology Research and Advisory Center , Moscow , Russia., Zhavoronkov AA; a Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology , Moscow , Russia.; d Pathway Pharmaceuticals , Wan Chai, Hong Kong , Hong Kong SAR., Kovalchuk I; i Department of Biological Sciences , University of Lethbridge , Lethbridge , AB , Canada., Kovalchuk O; i Department of Biological Sciences , University of Lethbridge , Lethbridge , AB , Canada., Kushch AA; e N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology of the Ministry of Health of the Russian Federation , Moscow , Russia.

Publikováno v: Cell cycle (Georgetown, Tex.) [Cell Cycle] 2016 Dec 16; Vol. 15 (24), pp. 3378-3389.

Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs.

Autor: Zhavoronkov A; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology Dolgoprudny, Russia ; First Oncology Research and Advisory Center Moscow, Russia ; The Biogerontology Research Foundation London, UK ; Department of Experimental and Molecular Medicine, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology Moscow, Russia., Buzdin AA; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology Dolgoprudny, Russia ; First Oncology Research and Advisory Center Moscow, Russia ; Department of Experimental and Molecular Medicine, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology Moscow, Russia ; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences Moscow, Russia., Garazha AV; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology Dolgoprudny, Russia ; First Oncology Research and Advisory Center Moscow, Russia ; Department of Experimental and Molecular Medicine, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology Moscow, Russia ; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences Moscow, Russia., Borisov NM; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology Dolgoprudny, Russia ; First Oncology Research and Advisory Center Moscow, Russia ; Burnasyan Federal Medical Biophysical Center Moscow, Russia., Moskalev AA; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology Dolgoprudny, Russia ; Department of Ecology, Syktyvkar State University Syktyvkar, Russia ; Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences Syktyvkar, Russia.

Publikováno v: Frontiers in genetics [Front Genet] 2014 Mar 03; Vol. 5, pp. 49. Date of Electronic Publication: 2014 Mar 03 (Print Publication: 2014).