Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner

Autor: Wang, Meng, Brandt, Laura T.L., Wang, Xiaonan, Russell, Holly, Mitchell, Emily, Kamimae-Lanning, Ashley N., Brown, Jill M., Dingler, Felix A., Garaycoechea, Juan I., Isobe, Tomoya, Kinston, Sarah J., Gu, Muxin, Vassiliou, George S., Wilson, Nicola K., Göttgens, Berthold, Patel, Ketan J.

Publikováno v: In Molecular Cell 20 July 2023 83(14):2417-2433

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

Autor: Pontel, Lucas B., Rosado, Ivan V., Burgos-Barragan, Guillermo, Garaycoechea, Juan I., Yu, Rui, Arends, Mark J., Chandrasekaran, Gayathri, Broecker, Verena, Wei, Wei, Liu, Limin, Swenberg, James A., Crossan, Gerry P., Patel, Ketan J.

Publikováno v: In Molecular Cell 1 October 2015 60(1):177-188

Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair

Autor: Hodskinson, Michael R.G., Silhan, Jan, Crossan, Gerry P., Garaycoechea, Juan I., Mukherjee, Shivam, Johnson, Christopher M., Schärer, Orlando D., Patel, Ketan J.

Publikováno v: In Molecular Cell 8 May 2014 54(3):472-484

Why does the bone marrow fail in Fanconi anemia?

Autor: Garaycoechea, Juan I., Patel, K.J.

Publikováno v: In Blood 2 January 2014 123(1):26-34

Aldehyde driven transcriptional stress triggers an anorexic DNA damage response:Formaldehyde driven transcriptional stress triggers an anorexic DNA damage response

Autor: Mulderrig, Lee, Garaycoechea, Juan I, Tuong, Zewen K, Millington, Christopher, Dingler, Felix A., Ferdinand, John R, Gaul, Liam, Tadross, John A, Arends, Mark J, O'Rahilly, Stephen, Crossan, Gerry P, Clatworthy, Menna R., Patel, Ketan J

Publikováno v: Mulderrig, L, Garaycoechea, J I, Tuong, Z K, Millington, C, Dingler, F A, Ferdinand, J R, Gaul, L, Tadross, J A, Arends, M J, O'Rahilly, S, Crossan, G P, Clatworthy, M R & Patel, K J 2021, ' Aldehyde driven transcriptional stress triggers an anorexic DNA damage response : Formaldehyde driven transcriptional stress triggers an anorexic DNA damage response ', Nature . https://doi.org/10.1038/s41586-021-04133-7

Endogenous DNA damage can perturb transcription, triggering a multifaceted cellular response that repairs the damage, degrades RNA polymerase II and shuts down global transcription1–4. This response is absent in the severe human disease Cockayne Sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::357a8a7731fc68c6e84738217ebd13b7
https://hdl.handle.net/20.500.11820/5c198932-e822-43cb-a2cf-56369f454de9