Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Garabet G. Toby"'
Autor:
Garabet G Toby, Tongyao Liu, Yang Buyue, Xin Zhang, Alan J Bitonti, Glenn F Pierce, Jurg M Sommer, Haiyan Jiang, Robert T Peters
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148255 (2016)
INTRODUCTION:Hemophilia B is an inherited X chromosome-linked disorder characterized by impaired blood clotting owing to the absence of functional coagulation factor IX. Due to the relatively short half-life of factor IX, patients with hemophilia B r
Externí odkaz:
https://doaj.org/article/58c4ecd32473436ca225422f97a166da
Publikováno v:
BioTechniques, Vol 29, Iss 2, Pp 278-288 (2000)
Two-hybrid systems have become favored tools for detection and analysis of protein interactions because of their low cost and ease of use compared to biochemical or biophysical interaction technologies. It is possible to augment the utility of two-hy
Externí odkaz:
https://doaj.org/article/ff4ba881a990414d9332608e4000cdaf
Autor:
Yang Buyue, Tongyao Liu, John D Kulman, Garabet G Toby, George D Kamphaus, Susannah Patarroyo-White, Qi Lu, Thomas J Reidy, Baisong Mei, Haiyan Jiang, Glenn F Pierce, Jurg M Sommer, Robert T Peters
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113600 (2014)
Recombinant factor VIII Fc (rFVIIIFc) is a fusion protein consisting of a single B-domain-deleted (BDD) FVIII linked recombinantly to the Fc domain of human IgG1 to extend half-life. To determine if rFVIIIFc could be further improved by maintaining t
Externí odkaz:
https://doaj.org/article/9f7063df33694e378018959bd4c66d30
Biochemical and functional characterization of a recombinant monomeric factor VIII–Fc fusion protein
Autor:
Qi Lu, John Kulman, Glenn F. Pierce, Robert T. Peters, Low Susan, Alan J. Bitonti, Garabet G. Toby, Tongyao Liu
Publikováno v:
Journal of Thrombosis and Haemostasis
Background: Hemophilia A results from a deficiency in factor VIII activity. Current treatment regimens require frequent dosing, owing to the short half-life of FVIII. A recombinant FVIII–Fc fusion protein (rFVIIIFc) was molecularly engineered to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f2a8d04558c404fc9e2e935dd8ac42
https://doi.org/10.1111/jth.12076
https://doi.org/10.1111/jth.12076
Publikováno v:
Annals of the New York Academy of Sciences. 1020:212-226
The detection and correct identification of cancer, especially at an early stage, are vitally important for patient survival and quality of life. Since signaling pathways play critical roles in cancer development and metastasis, methods that reliably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca28733013db902a32c7e85e65da30dd
https://doi.org/10.1196/annals.1310.018
https://doi.org/10.1196/annals.1310.018
Publikováno v:
Molecular and Cellular Biology. 23:2109-2122
The process of cellular morphogenesis is highly conserved in eukaryotes and is dependent upon the function of proteins that are centrally involved in specification of the cell cycle. The human enhancer of invasion clone 10 (HEI10) protein was identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0ffbf271dd3fbab61d2bccb4e1d4f6
https://doi.org/10.1128/mcb.23.6.2109-2122.2003
https://doi.org/10.1128/mcb.23.6.2109-2122.2003
Autor:
Garabet G. Toby, Erica A. Golemis
Publikováno v:
Methods. 24:201-217
The detection of physical interaction between two or more molecules of interest can be facilitated if the act of association between the interactive partners leads to the production of a readily observed biological or physical readout. Many interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdebe533ca4ffa69c50e10064754e7e
https://doi.org/10.1006/meth.2001.1182
https://doi.org/10.1006/meth.2001.1182
Autor:
Joanne Estojak, Garabet G. Toby, Erica A. Golemis, Susan F. Law, Sarah J. Fashena, Yuzhu Zhang
Publikováno v:
Experimental Cell Research. 252:224-235
HEF1, p130(Cas), and Efs define a family of multidomain docking proteins which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. HEF1 function has been specifically implicated in signaling pathways import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749419259b19c91132ae007e26139190
https://doi.org/10.1006/excr.1999.4609
https://doi.org/10.1006/excr.1999.4609
Publikováno v:
BioTechniques. 24:637-640
The pcDNA3 mammalian expression vector uses the cytomegalovirus (CMV) promoter to express proteins cloned into an adjacent polylinker. We have modified this vector to create three different targeting constructs: Go to Plasma Membrane (pGTM), Go to Nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c91bbc42236e524ec648e892d42dec
https://doi.org/10.2144/98244st05
https://doi.org/10.2144/98244st05
Autor:
Xin Zhang, Robert T. Peters, Alan J. Bitonti, Haiyan Jiang, Yang Buyue, Tongyao Liu, Jurg M. Sommer, Glenn F. Pierce, Garabet G. Toby
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 2, p e0148255 (2016)
PLoS ONE, Vol 11, Iss 2, p e0148255 (2016)
Introduction Hemophilia B is an inherited X chromosome–linked disorder characterized by impaired blood clotting owing to the absence of functional coagulation factor IX. Due to the relatively short half-life of factor IX, patients with hemophilia B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d404f885bdde95018324c5cea517d5e
https://doi.org/10.1371/journal.pone.0148255
https://doi.org/10.1371/journal.pone.0148255