Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells

Autor: Forment, JV, Herzog, M, Coates, J, Konopka, T, Gapp, BV, Nijman, SM, Adams, DJ, Keane, TM, Jackson, SP

In model organisms, classical genetic screening via random mutagenesis provides key insights into the molecular bases of genetic interactions, helping to define synthetic lethality, synthetic viability and drug-resistance mechanisms. The limited gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5adc6b758ca6424b5ba809f9317c8d8a

HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.

Autor: Kogler M; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria., Tortola L; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria. josef.penninger@ubc.ca luigi.tortola@biol.ethz.ch.; Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, Switzerland., Negri GL; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.; Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Leopoldi A; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria., El-Naggar AM; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.; Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia Governorate, Egypt., Mereiter S; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria., Gomez-Diaz C; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria., Nitsch R; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria.; Advanced Medicines Safety, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Tortora D; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Kavirayani AM; Vienna BioCentre Core Facilities, Vienna BioCentre, Vienna, Austria., Gapp BV; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria., Rao S; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria., Uribesalgo I; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria., Hoffmann D; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria., Cikes D; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria., Novatchkova M; Research Institute of Molecular Pathology, Vienna BioCentre, Vienna, Austria., Williams DA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts., Trent JM; Translational Genomics Research Institute (TGen), Phoenix, Arizona., Ikeda F; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria., Daugaard M; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Hagelkruys A; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria., Sorensen PH; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada., Penninger JM; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCentre, Vienna, Austria. josef.penninger@ubc.ca luigi.tortola@biol.ethz.ch.; Department of Medical Genetics, Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada.

Publikováno v: Cancer research [Cancer Res] 2020 Jul 15; Vol. 80 (14), pp. 3009-3022. Date of Electronic Publication: 2020 May 04.

Parallel reverse genetic screening in mutant human cells using transcriptomics.

Autor: Gapp BV; Nuffield Department of Clinical Medicine, Ludwig Cancer Research Ltd. University of Oxford, Oxford, UK., Konopka T; Nuffield Department of Clinical Medicine, Ludwig Cancer Research Ltd. University of Oxford, Oxford, UK., Penz T; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Dalal V; Nuffield Department of Clinical Medicine, Ludwig Cancer Research Ltd. University of Oxford, Oxford, UK., Bürckstümmer T; Horizon Genomics, Vienna, Austria., Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria Max Planck Institute for Informatics, Saarbrücken, Germany., Nijman SM; Nuffield Department of Clinical Medicine, Ludwig Cancer Research Ltd. University of Oxford, Oxford, UK CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Nuffield Department of Clinical Medicine, Target Discovery Institute University of Oxford, Oxford, UK Sebastian.nijman@ludwig.ox.ac.uk.

Publikováno v: Molecular systems biology [Mol Syst Biol] 2016 Aug 01; Vol. 12 (8), pp. 879. Date of Electronic Publication: 2016 Aug 01.

Synthetic lethal vulnerabilities of cancer.

Autor: Fece de la Cruz F; CeMM - Research Center for Molecular Medicine of the Austrian Academy of Sciences, A1090 Vienna, Austria; email: snijman@cemm.oeaw.ac.at., Gapp BV, Nijman SM

Publikováno v: Annual review of pharmacology and toxicology [Annu Rev Pharmacol Toxicol] 2015; Vol. 55, pp. 513-31. Date of Electronic Publication: 2014 Oct 09.

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

Autor: Jacobson LS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461., Lima H Jr; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461., Goldberg MF; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461., Gocheva V; Department of Cancer Biology and Genetics, Memorial Sloan-Kettering, New York, New York 10065., Tsiperson V; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461., Sutterwala FS; Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52241., Joyce JA; Department of Cancer Biology and Genetics, Memorial Sloan-Kettering, New York, New York 10065., Gapp BV; Department of Biochemistry, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Blomen VA; Department of Biochemistry, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461., Brummelkamp TR; Department of Biochemistry, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Diaz-Griffero F; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461., Brojatsch J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461. Electronic address: jurgen.brojatsch@einstein.yu.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2013 Mar 15; Vol. 288 (11), pp. 7481-7491. Date of Electronic Publication: 2013 Jan 07.