Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gaoxian Chen"'
Autor:
Gaoxian Chen, Lorena Orozco, Sophia Parmisano, James W.S. Jahng, Carlos D. Vera, Yan Zhuge, Joseph C. Wu, Detlef Obal
Publikováno v:
Stem Cell Research, Vol 72, Iss , Pp 103218- (2023)
Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease, with an estimated 500–1000 new cases diagnosed every year. A portion of these cases may be caused by mutations in the BMPR2 gene, suggesting a possible genetic component in the de
Externí odkaz:
https://doaj.org/article/e091d86e6af746e1ae827664b860c6fc
Autor:
Gaoxian Chen, Detlef Obal
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
G protein-coupled receptors (GPCRs) are a large family of transmembrane proteins that play a major role in many physiological processes, and thus GPCR-targeted drug development has been widely promoted. Although research findings generated in immorta
Externí odkaz:
https://doaj.org/article/11f1ca797d714431a232757207cb5d13
Autor:
Liwen Hong, Gaoxian Chen, Zhengwei Cai, Hua Liu, Chen Zhang, Fei Wang, Zeyu Xiao, Jie Zhong, Lei Wang, Zhengting Wang, Wenguo Cui
Publikováno v:
Advanced Science, Vol 9, Iss 20, Pp n/a-n/a (2022)
Abstract Emerging evidence indicates that a vicious cycle between inflammation and microthrombosis catalyzes the pathogenesis of inflammatory bowel disease (IBD). Over‐stimulated inflammation triggers a coagulation cascade and leads to microthrombo
Externí odkaz:
https://doaj.org/article/53cd7fe73b3c429183c42de8b107edcf
Autor:
Shuai Gao, Guoguang Wei, Sihang Zhang, Binbin Zheng, Jiaojiao Xu, Gaoxian Chen, Mingwang Li, Shaoli Song, Wei Fu, Zeyu Xiao, Wei Lu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
There is a balance between the fluorescence and photothermal properties of fluorescent molecules. Here, the authors report on an NIR-II fluorophore which binds with human serum albumin changing the equilibrium, increasing the photothermal efficiency,
Externí odkaz:
https://doaj.org/article/fbf0642c74034a9fb10ec9be72017b09
Autor:
Mengni Yi, Tianjiao Wei, Yanxia Wang, Qin Lu, Gaoxian Chen, Xiaoling Gao, Herbert M. Geller, Hongzhuan Chen, Zhihua Yu
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-15 (2017)
Abstract Background Reactive astrogliosis is one of the significantly pathological features in ischemic stroke accompanied with changes in gene expression, morphology, and proliferation. KCa3.1 was involved in TGF-β-induced astrogliosis in vitro and
Externí odkaz:
https://doaj.org/article/ed8aa4543f434e63b6f6abbe2cf59129
DNA-modularized construction of bivalent ligands precisely regulates receptor binding and activation
Autor:
Na Zhao, Wenwei Wu, Ying Wang, Kun Song, Gaoxian Chen, Yingzhi Chen, Ruowen Wang, Jianrong Xu, Kai Cui, Hongzhuan Chen, Weihong Tan, Jian Zhang, Zeyu Xiao
Publikováno v:
Chem. 9:1047-1054
Autor:
Zeyu Xiao, Wenwei Wu, Kai Cui, Ruike Li, Gaoxian Chen, Yingzhi Chen, Qingyun Li, Na Zhao, Yanna Cui, Chenchen Fan
Publikováno v:
ACS Sensors. 6:3234-3241
Exosome-based liquid biopsy holds great potential in monitoring tumor progression. Current exosome detection biosensors rely on signal amplification strategies to improve sensitivity; however, these strategies pay little attention to manipulating the
Publikováno v:
ACS applied bio materials. 3(7)
Artificial cells have led to many potential applications in synthetic biology and served as useful platforms to study biological phenomena. With increasing development of DNA nanotechnology, DNA-based nanostructures with various morphologies have bee
Autor:
Lei Fu, Miao Lin, Shan Cong, Mingwang Li, Chenchen Fan, Xiajing Gu, Zhigang Zhao, Yuanyuan Qiu, Zeyu Xiao, Gaoxian Chen, Xiaohong Fang
Publikováno v:
ACS Applied Materials & Interfaces. 11:23436-23444
Surface-enhanced Raman scattering (SERS) probes have exhibited great potential in biomedical applications. However, currently reported SERS probes are mainly fabricated by nondegradable Au or Ag nanostructures, which are not favorably cleared from th
Autor:
Jiaojiao Xu, Zeyu Xiao, Shuai Gao, Binbin Zheng, Mingwang Li, Shaoli Song, Sihang Zhang, Wei Fu, Guoguang Wei, Gaoxian Chen, Wei Lu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Fluorophores with donor-acceptor-donor groups with the emission spanning the second near-infrared window (NIR-II) have recently received great attention for biomedical application. Yet, the mechanism underlying the equilibrium between fluorescence (r