Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Gaowei Mao"'
Autor:
Andrew M. Lamade, Limin Wu, Haider H. Dar, Heather L. Mentrup, Indira H. Shrivastava, Michael W. Epperly, Claudette M. St Croix, Yulia Y. Tyurina, Tamil S. Anthonymuthu, Qin Yang, Aleksandr A. Kapralov, Zhentai Huang, Gaowei Mao, Andrew A. Amoscato, Zachary E. Hier, Margarita A. Artyukhova, Galina Shurin, Joel C. Rosenbaum, Peter J. Gough, John Bertin, Andrew P. VanDemark, Simon C. Watkins, Kevin P. Mollen, Ivet Bahar, Joel S. Greenberger, Valerian E. Kagan, Michael J. Whalen, Hülya Bayır
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102232- (2022)
Ferroptosis and necroptosis are two pro-inflammatory cell death programs contributing to major pathologies and their inhibition has gained attention to treat a wide range of disease states. Necroptosis relies on activation of RIP1 and RIP3 kinases. F
Externí odkaz:
https://doaj.org/article/f183853d46e94325b02ce4c0422c4965
Autor:
Lauren J. Wegman-Points, Melissa L.T. Teoh-Fitzgerald, Gaowei Mao, Yueming Zhu, Melissa A. Fath, Douglas R. Spitz, Frederick E. Domann
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 847-854 (2014)
Retroviral transformation has been associated with pro-proliferative oncogenic signaling in human cells. The current study demonstrates that transduction of human breast carcinoma cells (MDA-MB231) with LXSN and QCXIP retroviral vectors causes signif
Externí odkaz:
https://doaj.org/article/66a2771843b14e808f7af21c56f97542
Autor:
Yoel Sadovsky, Ivet Bahar, Charleen T. Chu, Yu-Jia Zhai, Karolina Mikulska-Ruminska, Sergey Korolev, Timothy J Greenamyre, Jie Sun, Rong-Rong He, Alexandr A. Kapralov, Yulia Y. Tyurina, Haider H. Dar, Valerian E. Kagan, Hülya Bayır, Ming-Hai Pan, Teresa G. Hastings, Vladimir A. Tyurin, Hai-Biao Gong, Wanyang Sun, Ofer Beharier, Gaowei Mao, Ian J. Miller, Plamena R. Angelova, Andrew A. Amoscato, Andrey Y. Abramov, Dan-Hua Lu, Wen-Jun Duan, Indira H. Shrivastava, Tamil S. Anthonymuthu
Publikováno v:
Nature chemical biology
Ferroptosis, triggered by discoordination of iron, thiols and lipids, leads to the accumulation of 15-hydroperoxy (Hp)-arachidonoyl-phosphatidylethanolamine (15-HpETE-PE), generated by complexes of 15-lipoxygenase (15-LOX) and a scaffold protein, pho
Autor:
Huan Wang, Jing-Kang Zhu, Lan Cheng, Gaowei Mao, Hong Chen, Xiaoying Wu, Huiwu Hong, Canwang Wang, Pengcheng Lin, Jie Chen, Rene Nfornah Maboh, Hui Chen
Publikováno v:
Journal of hypertension. 40(4)
CACNA1D gene, which encodes the α1 subunit of the Cav1.3 L-type calcium channel effectively regulates intracellular Ca2+ stability. In recent years, clinical studies have shown that the CACNA1D polymorphisms were associated with hypertension.The pur
Publikováno v:
Journal of cardiovascular translational research. 15(5)
Abnormal phenotype switch in vascular smooth muscle cells (VSMCs) plays an important role in the initiation and progression of vascular proliferative diseases. Annexin A2 (ANXA2), related to the pro-inflammatory response, contributes to the prolifera
Autor:
Cody J. Freedman, Jennifer M. Bomberger, Becca A. Flitter, Yohei Doi, Janet S. Lee, Erkan Bayir, Gaowei Mao, Joseph M. Pilewski, Indira H. Shrivastava, Matthew R. Parsek, Valerian E. Kagan, Joel S. Greenberger, Abiola F. Ogunsola, Hong Wang, Haider H. Dar, Rama K. Mallampalli, Theodore R. Holman, Tamil S. Anthonymuthu, Simon C. Watkins, Karolina Mikulska-Ruminska, Yulia Y. Tyurina, Jordan R. Gaston, Claudette M. St. Croix, Hsiu Chi Ting, Ivet Bahar, James Krieger, Catherine R. Armbruster, Alexandr A. Kapralov, Hülya Bayır, Vladimir A. Tyurin
Publikováno v:
Journal of Clinical Investigation. 128:4639-4653
Ferroptosis is a death program executed via selective oxidation of arachidonic acid–phosphatidylethanolamines (AA-PE) by 15-lipoxygenases. In mammalian cells and tissues, ferroptosis has been pathogenically associated with brain, kidney, and liver
Autor:
Vladimir A. Tyurin, Joel S. Greenberger, Vladimir B. Ritov, Marcus Conrad, Tamil S. Anthonymuthu, Yulia Y. Tyurina, Andrew A. Amoscato, Brent R. Stockwell, Jianfei Jiang, José Pedro Friedmann Angeli, Simon C. Watkins, Judith Klein-Seetharaman, Dariush Mohammadyani, Valerian E. Kagan, Gaowei Mao, Ivet Bahar, Sebastian Doll, Hülya Bayır, Qin Yang, Haider H. Dar, Alexandr A. Kapralov, Rama K. Mallampalli, Feng Qu, Claudette M. St. Croix, Bing Liu, Bettina Proneth
Publikováno v:
Nature Chemical Biology. 13:81-90
Enigmatic lipid peroxidation products have been claimed as the proximate executioners of ferroptosis-a specialized death program triggered by insufficiency of glutathione peroxidase 4 (GPX4). Using quantitative redox lipidomics, reverse genetics, bio
Autor:
Hsiu-Chi Ting, Vladimir A. Tyurin, Anastasia Nesterova, Tamil S. Anthonymuthu, Indira H. Shrivastava, Marcus Conrad, Karolina Mikulska-Ruminska, Haider H. Dar, Yulia Y. Tyurina, Joel C. Rosenbaum, Zachary E. Hier, Andrew P. VanDemark, Gaowei Mao, Ivet Bahar, John A. Kellum, Elizabeth M. Kenny, Andrew A. Amoscato, Valerian E. Kagan, Hülya Bayır, Jinming Zhao, Sally E. Wenzel
Publikováno v:
J. Am. Chem. Soc. 140, 17835-17839 (2018)
sn2-15-Hydroperoxy-eicasotetraenoyl-phosphatidylethanolamines (sn2-15-HpETE-PE) generated by mammalian 15-lipoxygenase/phosphatidylethanolamine binding protein-1 (15-LO/PEBP1) complex is a death signal in a recently identified type of programmed cell
Autor:
Gaowei Mao
Manganese superoxide dismutase (MnSOD), is a mitochondria-localized antioxidant enzyme that scavenges superoxide anions generated in the respiratory chains, has been known to play an important role in the radioprotection, and function as a tumor supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba8d156abf5ff024d896dfaacf414ac2
https://doi.org/10.17077/etd.xlb9pe09
https://doi.org/10.17077/etd.xlb9pe09
Autor:
Gaowei Mao, Andrew A. Amoscato, Jianfei Jiang, Judith Klein-Seetharaman, John J. Maguire, Hülya Bayır, Amin Cheikhi, Valerian E. Kagan, Feng Qu, Claudette M. St. Croix, Zhentai Huang, Alexandr A. Kapralov, Vladimir A. Tyurin, Yulia Y. Tyurina, Joan Planas-Iglesias
Publikováno v:
ACS Chemical Biology. 11:530-540
While opto-genetics has proven to have tremendous value in revealing the functions of the macromolecular machinery in cells, it is not amenable to exploration of small molecules such as phospholipids (PLs). Here, we describe a redox opto-lipidomics a