Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Gaorav P Gupta"'
Autor:
Hui Xiao Chao, Randy I Fakhreddin, Hristo K Shimerov, Katarzyna M Kedziora, Rashmi J Kumar, Joanna Perez, Juanita C Limas, Gavin D Grant, Jeanette Gowen Cook, Gaorav P Gupta, Jeremy E Purvis
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 3, Pp 1-19 (2019)
Abstract The cell cycle is canonically described as a series of four consecutive phases: G1, S, G2, and M. In single cells, the duration of each phase varies, but the quantitative laws that govern phase durations are not well understood. Using time
Externí odkaz:
https://doaj.org/article/81290e9fcfee4492b0f34caf81dfef6d
Autor:
John J. Krais, David J. Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson, Pooja Patel, Zemin Liu, Ryan Neumann-Domer, Robert G. Betsch, Andrea J. Bernhardy, Alice M. Bradbury, Jason Conger, Wei-Ting Yueh, Joseph Nacson, Richard T. Pomerantz, Gaorav P. Gupta, Joseph R. Testa, Neil Johnson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Homologous recombination (HR)-deficiency induces a dependency on DNA polymerase theta (Polθ/Polq)-mediated end joining, and Polθ inhibitors (Polθi) are in development for cancer therapy. BRCA1 and BRCA2 deficient cells are thought to be s
Externí odkaz:
https://doaj.org/article/1134d3c423c24ee9b10823404374aee9
Autor:
Chelsea M. Smith, Gaorav P. Gupta
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Deficiencies in homologous recombination (HR) repair lead to an accumulation of DNA damage and can predispose individuals to cancer. Polymerase theta (Pol θ, encoded by POLQ) is overexpressed by HR-deficient cancers and promotes cancer cell survival
Externí odkaz:
https://doaj.org/article/475662effcd54df99a7d238d5c3db799
Autor:
Megan E. Luedeman, Susanna Stroik, Wanjuan Feng, Adam J. Luthman, Gaorav P. Gupta, Dale A. Ramsden
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Poly(ADP) ribose polymerase (PARP) activity promotes, but is not required for, chromosome break repair by polymerase theta-mediated end joining (TMEJ). PARP activity promotes TMEJ by stimulating resection, a process that controls pathway choice.
Externí odkaz:
https://doaj.org/article/006e3279553f49e2bd2debeaa1b1755c
Autor:
Sm N. Udden, Qian Wang, Sunil Kumar, Venkat S. Malladi, Shwu-Yuan Wu, Shuguang Wei, Bruce A. Posner, Sophie Geboers, Noelle S. Williams, Yulun Liu, Jayesh K. Sharma, Ram S. Mani, Srinivas Malladi, Karla Parra, Mia Hofstad, Ganesh V. Raj, Jose M. Larios, Reshma Jagsi, Max S. Wicha, Ben Ho Park, Gaorav P. Gupta, Arul M. Chinnaiyan, Cheng-Ming Chiang, Prasanna G. Alluri
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Acquired mutations in the ligand-binding domain (LBD) of the gene encoding estrogen receptor α (ESR1) are common mechanisms of endocrine therapy resistance in patients with metastatic ER+ breast cancer. The ESR1 Y537S mutation, in particular, is ass
Externí odkaz:
https://doaj.org/article/d418606d92724bfe9c78d27a68b05327
Autor:
Wanjuan Feng, Dennis A. Simpson, Juan Carvajal-Garcia, Brandon A. Price, Rashmi J. Kumar, Lisle E. Mose, Richard D. Wood, Naim Rashid, Jeremy E. Purvis, Joel S. Parker, Dale A. Ramsden, Gaorav P. Gupta
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Polymerase theta is a widely conserved DNA polymerase that mediates Theta Mediated End Joining. Here authors present a synthetic lethal CRISPR screen to identify DDR gene mutations that induce cellular addiction to Pol theta.
Externí odkaz:
https://doaj.org/article/566f9084f7004b948bfb7d7d81816fbb
Autor:
Katerina D. Fagan-Solis, Dennis A. Simpson, Rashmi J. Kumar, Luciano G. Martelotto, Lisle E. Mose, Naim U. Rashid, Alice Y. Ho, Simon N. Powell, Y. Hannah Wen, Joel S. Parker, Jorge S. Reis-Filho, John H.J. Petrini, Gaorav P. Gupta
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1385-1399.e7 (2020)
Summary: The Mre11-Rad50-Nbs1 complex is a DNA double-strand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly understood. Using a genet
Externí odkaz:
https://doaj.org/article/c748e1c4c3444689abb982bb24303a91
Autor:
David M. Routman, Sunil Kumar, Bisham S. Chera, Krishan R. Jethwa, Kathryn M. Van Abel, Kelsey Frechette, Todd DeWees, Michael Golafshar, Joaquin J. Garcia, Daniel L. Price, Jan L. Kasperbauer, Samil H. Patel, Michelle A. Neben-Wittich, Nadia L. Laack, Ashish V. Chintakuntlawar, Katharine A. Price, Minetta C. Liu, Robert L. Foote, Eric J. Moore, Gaorav P. Gupta, Daniel J. Ma
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 113:530-538
The purpose of our study is to determine the rate of detectability of ctHPVDNA after surgery but before adjuvant therapy in patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV[+]OPSCC) and to investigate whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4173c09e91c70d24c13e849dcbbf0f
https://doi.org/10.1016/j.ijrobp.2022.02.012
https://doi.org/10.1016/j.ijrobp.2022.02.012
Autor:
Derek Hoerres, Qunsheng Dai, Sandra Elmore, Siddharth Sheth, Gaorav P Gupta, Sunil Kumar, Margaret L Gulley
Publikováno v:
American Journal of Clinical Pathology.
Objectives Accurate monitoring of disease burden depends on accurate disease marker quantification. Although next-generation sequencing (NGS) is a promising technology for noninvasive monitoring, plasma cell-free DNA levels are often reported in misl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0fd4c9765e315a47ba73bc93783b1d3
https://doi.org/10.1093/ajcp/aqad055
https://doi.org/10.1093/ajcp/aqad055
Autor:
Melissa A. Troester, Katherine A. Hoadley, Cyrus Vaziri, Charles M. Perou, Gaorav P. Gupta, Michael I. Love, Erin L. Kirk, Alina M. Hamilton, Xiaohua Gao, Alex Lockhart, Markia A. Smith, Linnea T. Olsson, Sarah C. Van Alsten, Andrea Walens
Background:Aberrant expression of DNA repair pathways such as homologous recombination (HR) can lead to DNA repair imbalance, genomic instability, and altered chemotherapy response. DNA repair imbalance may predict prognosis, but variation in DNA rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26082be2ddd4e39d8e04cca6b3b9f150
https://doi.org/10.1158/1055-9965.c.6660312.v1
https://doi.org/10.1158/1055-9965.c.6660312.v1
