Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Gaohong, Dong"'
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Acne is a chronic inflammatory skin disease that primarily affects adolescents and is attributed to various factors, including hormonal changes, genetic predisposition, and environmental influences. It typically manifests in areas rich in sebaceous g
Externí odkaz:
https://doaj.org/article/1204c0bbd96346b5a338099080c14087
Autor:
Yodit Seifu, Shahrul Mt-Isa, Kyle Duke, Margaret Gamalo-Siebers, William Wang, Gaohong Dong, John Kolassa
Publikováno v:
Journal of Biopharmaceutical Statistics. :1-12
A fundamental problem in the regulatory evaluation of a therapy is assessing whether the benefit outweighs the associated risks. This work proposes designing a trial that assesses a composite endpoint consisting of benefit and risk, hence, making the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4faf399c10b9d36eaf936b92bc22a3c3
https://doi.org/10.1080/10543406.2022.2153202
https://doi.org/10.1080/10543406.2022.2153202
Autor:
James Song, Johan Verbeeck, Bo Huang, David C. Hoaglin, Margaret Gamalo-Siebers, Yodit Seifu, Duolao Wang, Freda Cooner, Gaohong Dong
Publikováno v:
Journal of Biopharmaceutical Statistics. 33:140-150
Generalized pairwise comparisons and win statistics (i.e., win ratio, win odds and net benefit) are advantageous in analyzing and interpreting a composite of multiple outcomes in clinical trials. An important limitation of these statistics is their i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b959881e966e7679f0b2e5bb9e6641
https://doi.org/10.1080/10543406.2022.2089156
https://doi.org/10.1080/10543406.2022.2089156
Autor:
Gaohong Dong, David C. Hoaglin, Bo Huang, Ying Cui, Duolao Wang, Yu Cheng, Margaret Gamalo‐Siebers
Publikováno v:
Pharmaceutical Statistics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56b01b979b54057cad27150b31c78622
https://doi.org/10.1002/pst.2293
https://doi.org/10.1002/pst.2293
Publikováno v:
Journal of biopharmaceutical statistics.
Overall survival, progression-free survival, objective response/complete response, and duration of (complete) response are frequently used as the primary and secondary efficacy endpoints for designs and analyses of oncology clinical trials. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ce560c9f1e32940a6b8a19879ee28c
https://pubmed.ncbi.nlm.nih.gov/36343174
https://pubmed.ncbi.nlm.nih.gov/36343174
Autor:
Gaohong Dong, Bo Huang, Johan Verbeeck, Ying Cui, James Song, Margaret Gamalo‐Siebers, Duolao Wang, David C. Hoaglin, Yodit Seifu, Tobias Mütze, John Kolassa
Publikováno v:
Pharmaceutical statisticsREFERENCES.
Conventional analyses of a composite of multiple time-to-event outcomes use the time to the first event. However, the first event may not be the most important outcome. To address this limitation, generalized pairwise comparisons and win statistics (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3905ff9eb3559e7eaae348aef0ac2c
https://pubmed.ncbi.nlm.nih.gov/35757986
https://pubmed.ncbi.nlm.nih.gov/35757986
Autor:
Suqin Han, Xu Yang, Tianyi Hao, Yanchen Yang, Gaohong Dong, Zhongwei Luo, Yufen Zhang, Yingxiao Tang, Miaomiao Lu
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eacb6794572bc9a156147c92b96fa4f
https://doi.org/10.2139/ssrn.4022153
https://doi.org/10.2139/ssrn.4022153
Autor:
David C. Hoaglin, Gaohong Dong, Junshan Qiu, Marc Vandemeulebroecke, Roland A. Matsouaka, Jiuzhou Wang, Yu-Wei Chang
Publikováno v:
Statistics in Biopharmaceutical Research. 12:99-106
To handle composite endpoints, the win ratio has been applied to data analysis and design of clinical trials. Its interpretation, however, is not always clear, and it could handle ties diff...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::260bf54da74bdaeb9416f9e45ef31bfd
https://doi.org/10.1080/19466315.2019.1575279
https://doi.org/10.1080/19466315.2019.1575279
Autor:
Bo Huang, GuangLei Yu, Margaret Gamalo-Siebers, Lu Mao, Jiuzhou Wang, David C. Hoaglin, Gaohong Dong
Publikováno v:
J Biopharm Stat
The win ratio method has received much attention in methodological research, ad hoc analyses, and designs of prospective studies. As the primary analysis, it supported the approval of tafamidis for the treatment of cardiomyopathy to reduce cardiovasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c9ffee267fdca37400885fcf76b77e
https://europepmc.org/articles/PMC7538385/
https://europepmc.org/articles/PMC7538385/
Autor:
Andreas Zuckermann, Shoei-Shen Wang, Heather Ross, Maria Frigerio, Howard J. Eisen, Christoph Bara, Daniel Hoefer, Maurizio Cotrufo, Gaohong Dong, Guido Junge, Anne M. Keogh
Publikováno v:
Journal of Transplantation, Vol 2011 (2011)
A six-month, multicenter, randomized, open-label study was undertaken to determine whether renal function is improved using reduced-exposure cyclosporine (CsA) versus standard-exposure CsA in 199 de novo heart transplant patients receiving everolimus
Externí odkaz:
https://doaj.org/article/ef456c1709a946a8807459f769923cbd