Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Gaofeng Zhan"'
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106627- (2024)
An increasing number of people undergo anesthesia and surgery. Perioperative neurocognitive and depressive disorders are common central nervous system complications with similar pathogeneses. These conditions pose a deleterious threat to human health
Externí odkaz:
https://doaj.org/article/9b4747a19eb241d69595e1397b3bdf60
Publikováno v:
Stress, Vol 27, Iss 1 (2024)
AbstractStress is a series of physical and psychological responses to external and internal environmental stimuli. Growing studies have demonstrated the detrimental impacts of acute restraint stress (ARS) and chronic restraint stress (CRS) on animal
Externí odkaz:
https://doaj.org/article/d4627cc0dcdf479b9beb2ba70a58a777
Publikováno v:
MedComm, Vol 4, Iss 6, Pp n/a-n/a (2023)
Abstract Stroke is a major public health concern worldwide. The lack of effective therapies heightens the need for new therapeutic agents. Previous study identified sirtuin 5 (SIRT5) as a positive regulator of microglia‐induced excessive neuroinfla
Externí odkaz:
https://doaj.org/article/42fe7eb38ecd42b8a94406cbc2eb9c4a
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background Excessive and unresolved neuroinflammation plays an important role in the pathophysiology of many neurological disorders, such as ischemic stroke, yet there are no effective treatments. Tripartite motif-containing 67 (TRIM67) play
Externí odkaz:
https://doaj.org/article/f1d3e4e58e664849911a54b57c153551
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-21 (2022)
Abstract Background Microglia-induced excessive neuroinflammation plays a crucial role in the pathophysiology of multiple neurological diseases, such as ischaemic stroke. Controlling inflammatory responses is considered a promising therapeutic approa
Externí odkaz:
https://doaj.org/article/874adb783f8844efb869de09e6e7e8e4
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Sleep plays an essential role in all studied animals with a nervous system. However, sleep deprivation leads to various pathological changes and neurobehavioral problems. Astrocytes are the most abundant cells in the brain and are involved in various
Externí odkaz:
https://doaj.org/article/9bd8dd2d58e54e0ea183c5935ee9a4dd
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106953- (2023)
Summary: Recent evidences have implicated that SENP3 is a deSUMOylase which possesses neuronal damage effects in cerebral ischemia. However, its role in microglia remains poorly understood. Here, we found that SENP3 was upregulated in the peri-infarc
Externí odkaz:
https://doaj.org/article/b805170aeb6c41889fff547879f4682d
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2476 (2023)
Astrocytes, the most abundant cells in the brain, are integral to sleep regulation. In the context of a healthy neural environment, these glial cells exert a profound influence on the sleep-wake cycle, modulating both rapid eye movement (REM) and non
Externí odkaz:
https://doaj.org/article/c4613bf45b304aa599802507fb1af7e6
Autor:
Jiangjiang Bi, Yifan Xu, Shiyong Li, Gaofeng Zhan, Dongyu Hua, Juan Tan, Xiaohui Chi, Hongbing Xiang, Fengjing Guo, Ailin Luo
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
ObjectiveTo investigate the role of gut microbiota and metabolites in POCD in elderly orthopedic patients, and screen the preoperative diagnostic indicators of gut microbiota in elderly POCD.Method40 elderly patients undergoing orthopedic surgery wer
Externí odkaz:
https://doaj.org/article/e61ee704a4524d8bbf455c05c8219a23
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 714 (2023)
Postoperative cognitive dysfunction (POCD) is a severe neurological complication after anesthesia and surgery. However, there is still a lack of effective clinical pharmacotherapy due to its unclear pathogenesis. Caffeic acid phenethyl ester (CAPE),
Externí odkaz:
https://doaj.org/article/79dcc8a4f2df40cca08c05b3b1e31bae