Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gaoen Ma"'
Autor:
Haote Han, Yanhui Yang, Yunjuan Jiao, Hui Qi, Zhuo Han, Luping Wang, Lijun Dong, Jingkui Tian, Bart Vanhaesebroeck, Xiaopeng Li, Junwen Liu, Gaoen Ma, Hetian Lei
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 738-748 (2023)
Gene editing with a CRISPR/Cas system is a novel potential strategy for treating human diseases. Pharmacological inhibition of phosphoinositide 3-kinase (PI3K) δ suppresses retinal angiogenesis in a mouse model of oxygen-induced retinopathy. Here we
Externí odkaz:
https://doaj.org/article/a65629075e5e4ec989f356e8fd057ee8
Autor:
Yajian Duan, Wenyi Wu, Jing Cui, Joanne Aiko Matsubara, Andrius Kazlauskas, Gaoen Ma, Xiaorong Li, Hetian Lei
Publikováno v:
BMC Ophthalmology, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Epiretinal membranes in patients with proliferative vitreoretinopathy (PVR) consist of extracellular matrix and a number of cell types including retinal pigment epithelial (RPE) cells and fibroblasts, whose contraction causes reti
Externí odkaz:
https://doaj.org/article/57d4d7414a144c54ae9ff57857f0c767
Publikováno v:
European Journal of Histochemistry, Vol 66, Iss 1 (2022)
Stroke is a brain system disease with a high fatality rate and disability rate. About 80% of strokes are ischemic strokes. Cerebral ischemia-reperfusion injury (CIRI) caused by ischemic stroke seriously affects the prognosis of stroke patients. The p
Externí odkaz:
https://doaj.org/article/cb4e8edbb8194c78b69486d2a90865cc
Autor:
Xionggao Huang, Guohong Zhou, Wenyi Wu, Yajian Duan, Gaoen Ma, Jingyuan Song, Ru Xiao, Luk Vandenberghe, Feng Zhang, Patricia A. D’Amore, Hetian Lei
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Abnormal angiogenesis causes many ocular diseases. Here the authors employ CRISPR/Cas9 gene editing technology to silence VEGFR2, a major regulator of angiogenesis, in retinal endothelium and abrogate angiogenesis in the mouse models of oxygen-induce
Externí odkaz:
https://doaj.org/article/f981fc904c1b403e9521fe12e9013ee3
Autor:
Wenyi Wu, Gaoen Ma, Hui Qi, Lijun Dong, Fang Chen, Yun Wang, Xingxing Mao, Xiaoqing Guo, Jing Cui, Joanne Aiko Matsubara, Bart Vanhaesebroeck, Xiaohe Yan, Guoming Zhang, Shaochong Zhang, Hetian Lei
Publikováno v:
Human Gene Therapy. 34:30-41
Abnormal angiogenesis is associated with myriad human diseases including proliferative diabetic retinopathy. Signaling transduction via phosphoinositide 3-kinases (PI3Ks) plays a critical role in angiogenesis. Herein, we showed that p110δ, the catal
Autor:
Lijun Dong, Haote Han, Xionggao Huang, Gaoen Ma, Dong Fang, Hui Qi, Zhuo Han, Luping Wang, Jingkui Tian, Bart Vanhaesebroeck, Guoming Zhang, Shaochong Zhang, Hetian Lei
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 102(12)
Proliferative vitreoretinopathy (PVR) is a fibrotic eye disease that develops after rhegmatogenous retinal detachment surgery and open-globe traumatic injury. Idelalisib is a specific inhibitor of phosphoinositide 3-kinase (PI3K) δ. While PI3Kδ is
Autor:
Luk H. Vandenberghe, Yajian Duan, Xionggao Huang, Patricia A. D'Amore, Jingyuan Song, Gaoen Ma, Hetian Lei, Guohong Zhou, Ru Xiao, Feng Zhang, Wenyi Wu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Nature Communications
Nature
Nature Communications
Nature
Angiogenesis, in which vascular endothelial growth factor receptor (VEGFR) 2 plays an essential role, is associated with a variety of human diseases including proliferative diabetic retinopathy and wet age-related macular degeneration. Here we report
Autor:
Hetian Lei, Wenyi Wu, Shizuo Mukai, Gaoen Ma, Patricia A. D'Amore, Guohong Zhou, Xionggao Huang
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Vascular endothelial growth factor receptor 2 (VEGFR2) plays a key role in VEGF-induced angiogenesis. The goal of this project was to test the hypothesis that editing genomic VEGFR2 loci using the technology of clustered regularly interspaced
Publikováno v:
Journal of Biological Chemistry. 291:16339-16347
The G309 allele of SNPs in the mouse double minute (MDM2) promoter locus is associated with a higher risk of cancer and proliferative vitreoretinopathy (PVR), but whether SNP G309 contributes to the pathogenesis of PVR is to date unknown. The cluster
Autor:
Jiantao Wang, Jing Z Cui, Gaoen Ma, Hetian Lei, Yanhui Yang, Xionggao Huang, Joanne A Matsubara, Andrius Kazlauskas, Jun Zhao
Publikováno v:
Experimental Eye Research. 197:108116
Platelet-derived growth factor (PDGF) is associated with clinical proliferative vitreoretinopathy (PVR), which is characterized by formation of sub- or epi-retinal membranes that consist of cells including retinal pigment epithelial (RPE) cells a