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Akademický článek

Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice

Autor: Shuai Shao, Cheng-Bo Xu, Cheng-Juan Chen, Gao-Na Shi, Qing-Lan Guo, Yu Zhou, Ya-Zi Wei, Lei Wu, Jian-Gong Shi, Tian-Tai Zhang

Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)

Abstract Background Chronic neuropathic pain is a frequent sequel to peripheral nerve injury and maladaptive nervous system function. Divanillyl sulfone (DS), a novel structural derivative of 4,4′-dihydroxydibenzyl sulfoxide from a traditional Chin

Externí odkaz: https://doaj.org/article/0b4571b88fae4395a158df62b70cbd6f

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Akademický článek

Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine

Autor: Gao-Na Shi, Min Hu, Chengjuan Chen, Junmin Fu, Shuai Shao, Yu Zhou, Lei Wu, Tiantai Zhang

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 13 (2021)

Background: Dendritic cells (DCs) are antigen-presenting cells that play a pivotal role in adaptive cell-mediated immunity by priming and activating T cells against specific tumour and pathogenic antigens. Methotrexate (MTX), a folate derivative, fun

Externí odkaz: https://doaj.org/article/ebd509183ad54ec5bc144479e05b19ba

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Quercetin Impedes Th17 Cell Differentiation to Mitigate Arthritis Involving PPARγ-Driven Transactivation of SOCS3 and Redistribution Corepressor SMRT from PPARγ to STAT3

Autor: Yan Yang, Gao‐na Shi, Xin Wu, Min Xu, Cheng‐juan Chen, Yu Zhou, Ya‐zi Wei, Lei Wu, Fen‐fang Cui, Lan Sun, Tian‐tai Zhang

Publikováno v: Molecular nutritionfood research. 66(12)

Quercetin (QU) is one of the most abundant flavonoids in plants and has attracted the attention of researchers because of its remarkable antirheumatoid arthritis (RA) effects and extremely low adverse reactions. However, the underlying mechanism need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd0010ea085d5f465a8c518ad3ecf77
https://pubmed.ncbi.nlm.nih.gov/35384292

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Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin

Autor: Zheng-Hong Qin, Gao-na Shi, Yu-lin Feng, Shilin Yang, Paul F. Reid, Hai-ming Lin, Yanli Liu

Publikováno v: Acta pharmacologica Sinica. 32(10)

To investigate the analgesic effect of cobratoxin (CTX), a long-chain α-neurotoxin from Thailand cobra venom, in a rat model of formalin-induced inflammatory pain.Inflammatory pain was induced in SD rats via injecting 5% formalin (50 μL) into the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b40883533ffc3a1329637f8b290b5ed
https://pubmed.ncbi.nlm.nih.gov/21841815

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