Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)

Autor: Knappskog, S., Gansmo, L. B., Dibirova, K., Metspalu, A., Cybulski, C., Peterlongo, P., Aaltonen, L., Vatten, L., Romundstad, P., Hveem, K., Devilee, P., Evans, G. D., Lin, D., Camp, G. V., Manolopoulos, V. G., Osorio, A., Milani, L., Ozcelik, T., Zalloua, P., Mouzaya, F., Elena Bliznetz, Balanovska, E., Pocheshkova, E., Kucinskas, V., Atramentova, L., Nymadawa, P., Titov, K., Lavryashina, M., Yusupov, Y., Bogdanova, N., Koshel, S., Zamora, J., Wedge, D. C., Charlesworth, D., Dörk, T., Balanovsky, O., Lønning, P. E.

Publikováno v: OncoTarget
Scopus-Elsevier
University of Manchester-PURE
ResearcherID
Oncotarget
Knappskog, S, Gansmo, L B, Dibirova, K, Metspalu, A, Cybulski, C, Peterlongo, P, Aaltonen, L, Vatten, L, Romundstad, P, Hveem, K, Devilee, P, Evans, G D, Lin, D, Van Camp, G V, Manolopoulos, V G, Osorio, A, Milani, L, Ozcelik, T, Zalloua, P, Mouzaya, F, Bliznetz, E, Balanovska, E, Pocheshkova, E, Kucinskas, V, Atramentova, L, Nymadawa, P, Titov, K, Lavryashina, M, Yusupov, Y, Bogdanova, N, Koshel, S, Zamora, J, Wedge, D C, Charlesworth, D, Dörk, T, Balanovsky, O & Lønning, P E 2014, ' Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649) ', Oncotarget, vol. 5, no. 18, pp. 8223-8234 . https://doi.org/10.18632/oncotarget.1910
Oncotarget, 5(18), 8223-8234
Europe PubMed Central
University of Helsinki

The MDM2 promoter SNP285C is located on the SNP309G allele. While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and endometrial cancer. Assessing SNP2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::08f740fe57862b8c570499e9bcb0fb2e
https://hdl.handle.net/1956/9550