Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ganna Posternak"'
Autor:
Mikhail Ignatov, Akhil Jindal, Sergei Kotelnikov, Dmitri Beglov, Ganna Posternak, Xiaojing Tang, Pierre Maisonneuve, Gennady Poda, Robert A. Batey, Frank Sicheri, Adrian Whitty, Peter J. Tonge, Sandor Vajda, Dima Kozakov
Publikováno v:
Journal of the American Chemical Society. 145:7123-7135
Autor:
Chetan K. Chana, Pierre Maisonneuve, Ganna Posternak, Nicolas G.A. Grinberg, Juline Poirson, Samara M. Ona, Derek F. Ceccarelli, Pavel Mader, Daniel J. St-Cyr, Victor Pau, Igor Kurinov, Xiaojing Tang, Dongjing Deng, Weiren Cui, Wenji Su, Letian Kuai, Richard Soll, Mike Tyers, Hannes L. Röst, Robert A. Batey, Mikko Taipale, Anne-Claude Gingras, Frank Sicheri
Publikováno v:
Journal of Medicinal Chemistry. 65:12725-12746
Targeted protein degradation (TPD) strategies exploit bivalent small molecules to bridge substrate proteins to an E3 ubiquitin ligase to induce substrate degradation. Few E3s have been explored as degradation effectors due to a dearth of E3-binding s
Autor:
Stephen Orlicky, Jasmin Coulombe-Huntington, Clint James, Ganna Posternak, Thierry Bertomeu, Susan Kelso, Almer M. van der Sloot, Derek F. Ceccarelli, Susan Moore, Xiaojing Tang, Frank Sicheri, Mike Tyers, Daniel J. St-Cyr, Anne Marinier
Publikováno v:
Science advances. 7(44)
Pharmacological control of the ubiquitin-proteasome system (UPS) is of intense interest in drug discovery. Here, we report the development of chemical inhibitors of the ubiquitin-conjugating (E2) enzyme CDC34A (also known as UBE2R1), which donates ac
Autor:
Michael Prakesch, Rima Al-awar, Ahmed Aman, Pierre Maisonneuve, Lauren Caldwell, Derek F. Ceccarelli, Ganna Posternak, Theo Goullet de Rugy, Mikko Taipale, Igor Kurinov, Julia Kitaygorodsky, Pavel Mader, Karen Colwill, Gennady Poda, Brett Larsen, Anne-Claude Gingras, Kin Chan, Jeff Wrana, Ting Jin, Salima Daou, Marc Therrien, Stephen Orlicky, Hugo Lavoie, Daniel Durocher, Xiaojing Tang, Cassandra J. Wong, Frank Sicheri, David Uehling, Robert A. Batey, Zhe Yin, Stefan Maier
Publikováno v:
Nat Chem Biol
The RAF family kinases function in the RAS-ERK pathway to transmit signals from activated RAS to the downstream kinases MEK and ERK. This pathway regulates cell proliferation, differentiation and survival, enabling mutations in RAS and RAF to act as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d3e2daaba5123ff078df9ce3f29cce
https://europepmc.org/articles/PMC7862923/
https://europepmc.org/articles/PMC7862923/