A phospho-deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons.

Autor: Werynska K; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Drug Discovery Network Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland., Neumann E; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Cramer T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Ganley RP; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Gingras J; Department of Neuroscience, Amgen Inc, Cambridge, MA, USA., Zeilhofer HU; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Drug Discovery Network Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.

Publikováno v: The Journal of physiology [J Physiol] 2023 Sep; Vol. 601 (18), pp. 4121-4133. Date of Electronic Publication: 2023 Aug 20.

Diffuse noxious inhibitory controls and conditioned pain modulation: a shared neurobiology within the descending pain inhibitory system?

Autor: Sirucek L; Department of Chiropractic Medicine, Integrative Spinal Research Group, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland., Ganley RP; Institute for Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Zeilhofer HU; Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland.; Institute for Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Schweinhardt P; Department of Chiropractic Medicine, Integrative Spinal Research Group, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Publikováno v: Pain [Pain] 2023 Mar 01; Vol. 164 (3), pp. 463-468. Date of Electronic Publication: 2022 Jun 17.

Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold.

Autor: Albisetti GW; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland., Ganley RP; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland., Pietrafesa F; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland., Werynska K; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland., Magalhaes de Sousa M; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland., Sipione R; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland., Scheurer L; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland., Bösl MR; Institute of Experimental Biomedicine I, University Hospital Würzburg, and Rudolf Virchow Center, University of Würzburg, 97080 Würzburg, Germany., Pelczar P; Center for Transgenic Models, University of Basel, 4001 Basel, Switzerland., Wildner H; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland. Electronic address: hwildner@pharma.uzh.ch., Zeilhofer HU; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zürich, Switzerland; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zürich, 8093 Zürich, Switzerland; Center for Neuroscience Zurich (ZNZ), 8057 Zürich, Switzerland; Drug Discovery Network Zurich (DDNZ), 8057 Zürich, Switzerland. Electronic address: zeilhofer@pharma.uzh.ch.

Publikováno v: Neuron [Neuron] 2023 Jan 04; Vol. 111 (1), pp. 92-105.e5. Date of Electronic Publication: 2022 Nov 01.

Structural MRI Reveals Cervical Spinal Cord Atrophy in the P301L Mouse Model of Tauopathy: Gender and Transgene-Dosing Effects.

Autor: Sartoretti T; Institute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland., Ganley RP; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Ni R; Institute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland.; Zurich Neuroscience Center (ZNZ), Zurich, Switzerland., Freund P; Zurich Neuroscience Center (ZNZ), Zurich, Switzerland.; Balgrist University Hospital, University of Zurich, Zurich, Switzerland., Zeilhofer HU; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Zurich Neuroscience Center (ZNZ), Zurich, Switzerland.; Institute for Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Klohs J; Institute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland.; Zurich Neuroscience Center (ZNZ), Zurich, Switzerland.

Publikováno v: Frontiers in aging neuroscience [Front Aging Neurosci] 2022 May 02; Vol. 14, pp. 825996. Date of Electronic Publication: 2022 May 02 (Print Publication: 2022).

Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia.

Autor: Boyle KA; Spinal Cord Research Group, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QQ, UK., Gradwell MA; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle NSW 2308, Australia., Yasaka T; Department of Anatomy and Physiology, Saga University, Saga 849-8501, Japan., Dickie AC; Spinal Cord Research Group, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QQ, UK., Polgár E; Spinal Cord Research Group, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QQ, UK., Ganley RP; Spinal Cord Research Group, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QQ, UK., Orr DPH; Spinal Cord Research Group, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QQ, UK., Watanabe M; Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060-8638, Japan., Abraira VE; Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA., Kuehn ED; Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA., Zimmerman AL; Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA., Ginty DD; Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA., Callister RJ; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle NSW 2308, Australia., Graham BA; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle NSW 2308, Australia. Electronic address: brett.graham@newcastle.edu.au., Hughes DI; Spinal Cord Research Group, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address: david.i.hughes@glasgow.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2019 Jul 09; Vol. 28 (2), pp. 526-540.e6.