Výsledky vyhledávání - "Gangaplara A"

Akademický článek

Galectin-1 is associated with hematopoietic cell engraftment in murine MHC-mismatched allotransplantation

Autor: Ahmad Shaikh, Arunakumar Gangaplara, Abdoul Kone, Katherine Almengo, Mariama D. Kabore, Mohamed A.E. Ali, Xin Xu, Ankit Saxena, Maria Lopez-Ocasio, J. Philip McCoy, Courtney D. Fitzhugh

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Haploidentical hematopoietic cell transplantation (haplo-HCT) is associated with an increased risk of allograft rejection. Here, we employed a major histocompatibility complex (MHC)-mismatched allogeneic HCT (allo-HCT) murine model to better understa

Externí odkaz: https://doaj.org/article/24e35174d94942e4b4ebfeee39393ccf

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Akademický článek

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Akademický článek

Detection of autoreactive CD4 T cells using major histocompatibility complex class II dextramers

Autor: Kuszynski Charles, Gangaplara Arunakumar, Upadhyaya Bijaya, Massilamany Chandirasegaran, Reddy Jay

Publikováno v: BMC Immunology, Vol 12, Iss 1, p 40 (2011)

Abstract Background Tetramers are useful tools to enumerate the frequencies of antigen-specific T cells. However, unlike CD8 T cells, CD4 T cells - especially self-reactive cells - are challenging to detect with major histocompatibility complex (MHC)

Externí odkaz: https://doaj.org/article/1e5c3eba78514732aba4aa4b1e5cec74

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Akademický článek

Co-expression of Foxp3 and Helios facilitates the identification of human T regulatory cells in health and disease

Autor: Lyra Morina, Madalyn E. Jones, Cihan Oguz, Mariana J. Kaplan, Arunakumar Gangaplara, Courtney D. Fitzhugh, Christopher G. Kanakry, Ethan M. Shevach, Maja Buszko

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Foxp3 is regarded as the major transcription factor for T regulatory (Treg) cells and expression of Foxp3 is used to identify and quantitate Treg cells in mouse models. However, several studies have demonstrated that human CD4+ T conventional (Tconv)

Externí odkaz: https://doaj.org/article/d82042a167c74c42a972bee0383269e4

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Akademický článek

Transgenic Mice Expressing Functional TCRs Specific to Cardiac Myhc-α 334–352 on Both CD4 and CD8 T Cells Are Resistant to the Development of Myocarditis on C57BL/6 Genetic Background

Autor: Meghna Sur, Mahima T. Rasquinha, Rajkumar Arumugam, Chandirasegaran Massilamany, Arunkumar Gangaplara, Kiruthiga Mone, Ninaad Lasrado, Bharathi Yalaka, Aakash Doiphode, Channabasavaiah Gurumurthy, David Steffen, Jay Reddy

Publikováno v: Cells, Vol 12, Iss 19, p 2346 (2023)

Myocarditis is a predominant cause of congestive heart failure and sudden death in children and young adolescents that can lead to dilated cardiomyopathy. Lymphocytic myocarditis mediated by T cells can result from the recognition of cardiac antigens

Externí odkaz: https://doaj.org/article/c60b285be68d46558a1fa40cb9dff801

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Akademický článek

Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice

Autor: Pulak R. Nath, Dipasmita Pal-Nath, Sukhbir Kaur, Arunkumar Gangaplara, Thomas J. Meyer, Margaret C Cam, David D. Roberts

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

CD47 has established roles in the immune system for regulating macrophage phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory roles in natural killer and CD8+ T cells. CD47 limits antigen-dependent cytotoxic

Externí odkaz: https://doaj.org/article/33ea54c4797a4658a41cc1d7592c3ead

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