Výsledky vyhledávání - "Gangaplara A"

Akademický článek

Galectin-1 is associated with hematopoietic cell engraftment in murine MHC-mismatched allotransplantation

Autor: Ahmad Shaikh, Arunakumar Gangaplara, Abdoul Kone, Katherine Almengo, Mariama D. Kabore, Mohamed A.E. Ali, Xin Xu, Ankit Saxena, Maria Lopez-Ocasio, J. Philip McCoy, Courtney D. Fitzhugh

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Haploidentical hematopoietic cell transplantation (haplo-HCT) is associated with an increased risk of allograft rejection. Here, we employed a major histocompatibility complex (MHC)-mismatched allogeneic HCT (allo-HCT) murine model to better understa

Externí odkaz: https://doaj.org/article/24e35174d94942e4b4ebfeee39393ccf

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Akademický článek

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Akademický článek

Detection of autoreactive CD4 T cells using major histocompatibility complex class II dextramers

Autor: Kuszynski Charles, Gangaplara Arunakumar, Upadhyaya Bijaya, Massilamany Chandirasegaran, Reddy Jay

Publikováno v: BMC Immunology, Vol 12, Iss 1, p 40 (2011)

Abstract Background Tetramers are useful tools to enumerate the frequencies of antigen-specific T cells. However, unlike CD8 T cells, CD4 T cells - especially self-reactive cells - are challenging to detect with major histocompatibility complex (MHC)

Externí odkaz: https://doaj.org/article/1e5c3eba78514732aba4aa4b1e5cec74

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Akademický článek

Co-expression of Foxp3 and Helios facilitates the identification of human T regulatory cells in health and disease

Autor: Lyra Morina, Madalyn E. Jones, Cihan Oguz, Mariana J. Kaplan, Arunakumar Gangaplara, Courtney D. Fitzhugh, Christopher G. Kanakry, Ethan M. Shevach, Maja Buszko

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Foxp3 is regarded as the major transcription factor for T regulatory (Treg) cells and expression of Foxp3 is used to identify and quantitate Treg cells in mouse models. However, several studies have demonstrated that human CD4+ T conventional (Tconv)

Externí odkaz: https://doaj.org/article/d82042a167c74c42a972bee0383269e4

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Akademický článek

Transgenic Mice Expressing Functional TCRs Specific to Cardiac Myhc-α 334–352 on Both CD4 and CD8 T Cells Are Resistant to the Development of Myocarditis on C57BL/6 Genetic Background

Autor: Meghna Sur, Mahima T. Rasquinha, Rajkumar Arumugam, Chandirasegaran Massilamany, Arunkumar Gangaplara, Kiruthiga Mone, Ninaad Lasrado, Bharathi Yalaka, Aakash Doiphode, Channabasavaiah Gurumurthy, David Steffen, Jay Reddy

Publikováno v: Cells, Vol 12, Iss 19, p 2346 (2023)

Myocarditis is a predominant cause of congestive heart failure and sudden death in children and young adolescents that can lead to dilated cardiomyopathy. Lymphocytic myocarditis mediated by T cells can result from the recognition of cardiac antigens

Externí odkaz: https://doaj.org/article/c60b285be68d46558a1fa40cb9dff801

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Akademický článek

Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice

Autor: Pulak R. Nath, Dipasmita Pal-Nath, Sukhbir Kaur, Arunkumar Gangaplara, Thomas J. Meyer, Margaret C Cam, David D. Roberts

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

CD47 has established roles in the immune system for regulating macrophage phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory roles in natural killer and CD8+ T cells. CD47 limits antigen-dependent cytotoxic

Externí odkaz: https://doaj.org/article/33ea54c4797a4658a41cc1d7592c3ead

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Akademický článek

Attenuated strain of CVB3 with a mutation in the CAR-interacting region protects against both myocarditis and pancreatitis

Autor: Ninaad Lasrado, Arunakumar Gangaplara, Chandirasegaran Massilamany, Rajkumar Arumugam, Allison Shelbourn, Mahima T. Rasquinha, Rakesh H. Basavalingappa, Gustavo Delhon, Shi-Hua Xiang, Asit K. Pattnaik, David Steffen, Jay Reddy

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)

Abstract Coxsackievirus B3 (CVB3), is commonly implicated in myocarditis, which can lead to dilated cardiomyopathy, in addition to causing acute pancreatitis and meningitis. Yet, no vaccines are currently available to prevent this infection. Here, we

Externí odkaz: https://doaj.org/article/a4c70442348c476e871597050323e742

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