Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gang-Qing Yao"'
Autor:
Jae Geun Kim, Ben-Hua Sun, Marcelo O. Dietrich, Marco Koch, Gang-Qing Yao, Sabrina Diano, Karl Insogna, Tamas L. Horvath
Publikováno v:
Cell Reports, Vol 13, Iss 1, Pp 8-14 (2015)
The hypothalamus has been implicated in skeletal metabolism. Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affect AgRP neuronal circuit integrity. We found that mice with
Externí odkaz:
https://doaj.org/article/6d7eea16ef414f91a536336831e0ada5
Autor:
Patricia R. Peter, MD, Catherine A. Brownstein, PhD, Gang-Qing Yao, MD, Elizabeth A. Olear, MS, MA, Christine A. Simpson, MS, MT (ASCP), Pankaj B. Agrawal, MD, MMSC, Thomas O. Carpenter, MD, Karl L. Insogna, MD
Publikováno v:
AACE Clinical Case Reports, Vol 2, Iss 4, Pp ee278-ee283 (2016)
ABSTRACT: Objective: Rickets can be caused by a wide variety of underlying nutritional deficiencies or genetic defects. There is significant overlap in the clinical presentations of the various forms of rickets and the risk for misdiagnosis is great.
Externí odkaz:
https://doaj.org/article/8ea09908ee7b4aa186f63a6000ae5924
Autor:
Jared Kaplan, Steven Tommasini, Gang-Qing Yao, Meiling Zhu, Sayoko Nishimura, Sevanne Ghazarian, Angeliki Louvi, Karl Insogna
Publikováno v:
Journal of the Endocrine Society. 7
ContextX-linked hypophosphatemia (XLH) is a genetic disease, causing life-long hypophosphatemia due to overproduction of fibroblast growth factor 23 (FGF23). XLH is associated with Chiari malformations, cranial synostosis, and syringomyelia. FGF23 si
Publikováno v:
Calcif Tissue Int
Sphingosine-1-phosphate (S1P) is an anabolic clastokine. Colony Stimulating Factor 1 (CSF1) induces expression of the rate limiting enzyme required for S1P synthesis, sphingosine kinase 1 (SPHK1) in bone in vivo, and in osteoclasts in vitro. To study
Autor:
Edwin Siu, Ben-hua Sun, Meiling Zhu, Christine A. Simpson, Gang-Qing Yao, Joanne M. Walker, Karl L. Insogna
Publikováno v:
Endocrinology
Sphingosine-1-phosphate (S1P) is an anabolic clastokine. Sphingosine kinase (SPHK) is the rate-limiting enzyme in S1P production and has 2 isoforms. To evaluate the roles of SPHK1 and SPHK2 in bone, we examined the skeletal phenotype of mice with sel
Autor:
Sabrina Diano, Tamas L. Horvath, Marco Koch, Gang-Qing Yao, Ben-hua Sun, Jae Geun Kim, Karl L. Insogna, Marcelo O. Dietrich
Publikováno v:
Cell Reports, Vol 13, Iss 1, Pp 8-14 (2015)
The hypothalamus has been implicated in skeletal metabolism (Ducy et al., 2000; Sato et al., 2007; Yadav et al., 2009). Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affec
Publikováno v:
Journal of Biological Chemistry. 289:6775-6790
Colony-stimulating factor 1 (CSF1) is known to promote osteoclast progenitor survival, but its roles in osteoclast differentiation and mature osteoclast function are less well understood. In a microarray screen, Jun dimerization protein 2 (JDP2) was
Autor:
Christine A. Simpson, Karl L. Insogna, Thomas O. Carpenter, Elizabeth Olear, Pankaj B. Agrawal, Catherine A. Brownstein, Patricia R Peter, Gang-Qing Yao
Publikováno v:
AACE Clinical Case Reports, Vol 2, Iss 4, Pp ee278-ee283 (2016)
Objective: Rickets can be caused by a wide variety of underlying nutritional deficiencies or genetic defects. There is significant overlap in the clinical presentations of the various forms of rickets and the risk for misdiagnosis is great. This repo
Publikováno v:
Journal of Bone and Mineral Metabolism. 30:408-418
To better define the biologic function of membrane-bound CSF1 (mCSF1) in vivo, we have generated mCSF1 knockout (k/o) mice. Spinal bone density (BMD) was 15.9% higher in k/o mice compared to wild-type (wt) controls (P < 0.01) and total BMD was increa
Publikováno v:
Journal of Bone and Mineral Metabolism. 29:141-148
Parathyroid hormone (PTH) is a potent ana- bolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We soug