Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Gang Greg, Wang"'
Autor:
Xinyi Chen, Yiran Guo, Ting Zhao, Jiuwei Lu, Jian Fang, Yinsheng Wang, Gang Greg Wang, Jikui Song
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Isoform 1 of DNA methyltransferase DNMT3A (DNMT3A1) specifically recognizes nucleosome monoubiquitylated at histone H2A lysine-119 (H2AK119ub1) for establishment of DNA methylation. Mis-regulation of this process may cause aberrant DNA methy
Externí odkaz:
https://doaj.org/article/f313f491cb134f9da42a75c9d183fafc
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract DNA methyltransferases DNMT3A- and DNMT3B-mediated DNA methylation critically regulate epigenomic and transcriptomic patterning during development. The hotspot DNMT3A mutations at the site of Arg822 (R882) promote polymerization, leading to
Externí odkaz:
https://doaj.org/article/66c300182321413d800b92d88c96ad1f
Autor:
Ling Cai, Gang Greg Wang
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTThe establishment, maintenance and dynamic regulation of three-dimensional (3D) chromatin structures provide an important means for partitioning of genome into functionally distinctive domains, which helps to define specialized gene expressio
Externí odkaz:
https://doaj.org/article/e540dd65ec1a4afcbcc8a175f94d48c2
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107115- (2023)
Summary: The histone methyltransferase EZH2 has been studied most extensively in the context of PRC2-dependent gene repression. Accumulating evidence indicates non-canonical functions for EZH2 in cancer contexts including promoting paradoxical gene e
Externí odkaz:
https://doaj.org/article/05129ec8ef54481fbaac6ad06e66a2d4
Autor:
Linfeng Gao, Yiran Guo, Mahamaya Biswal, Jiuwei Lu, Jiekai Yin, Jian Fang, Xinyi Chen, Zengyu Shao, Mengjiang Huang, Yinsheng Wang, Gang Greg Wang, Jikui Song
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In mammals, de novo DNA methyltransferase DNMT3B is essential for establishing DNA methylation patterns during embryonic development. Here the authors provide a structure-function characterization of homo-oligomeric DNMT3B, revealing the molecular ba
Externí odkaz:
https://doaj.org/article/73b70bc5fb234b0d9d8d9c3f4ec9a089
Autor:
Kwang‐Su Park, Lihuai Qin, Md Kabir, Kaixiu Luo, Brandon Dale, Yue Zhong, Arum Kim, Gang Greg Wang, Husnu Ümit Kaniskan, Jian Jin
Publikováno v:
Advanced Science, Vol 10, Iss 10, Pp n/a-n/a (2023)
Abstract Polycomb repressive complex 1 (PRC1) is an essential epigenetic regulator that mainly controls histone H2A Lys119 mono‐ubiquitination (H2AK119ub). B cell‐specific Moloney murine leukemia virus Integration site 1 (BMI1) and really interes
Externí odkaz:
https://doaj.org/article/5c133b6443db4c6c8875a050ae0d44cd
Autor:
Yiran Guo, Gang Greg Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The multi-subunit Polycomb Repressive Complex (PRC) 1 and 2 act, either independently or synergistically, to maintain and enforce a repressive state of the target chromatin, thereby regulating the processes of cell lineage specification and organisma
Externí odkaz:
https://doaj.org/article/1ce33219ec774904bee8391d962eb011
Autor:
Wendan Ren, Huitao Fan, Sara A. Grimm, Jae Jin Kim, Linhui Li, Yiran Guo, Christopher James Petell, Xiao-Feng Tan, Zhi-Min Zhang, John P. Coan, Jiekai Yin, Dae In Kim, Linfeng Gao, Ling Cai, Nelli Khudaverdyan, Burak Çetin, Dinshaw J. Patel, Yinsheng Wang, Qiang Cui, Brian D. Strahl, Or Gozani, Kyle M. Miller, Seán E. O’Leary, Paul A. Wade, Gang Greg Wang, Jikui Song
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its B
Externí odkaz:
https://doaj.org/article/a3cd3e4f8bb144c1bf23822e78c3db7f
Autor:
Jie Li, Phillip M. Galbo, Weida Gong, Aaron J. Storey, Yi-Hsuan Tsai, Xufen Yu, Jeong Hyun Ahn, Yiran Guo, Samuel G. Mackintosh, Ricky D. Edmondson, Stephanie D. Byrum, Jason E. Farrar, Shenghui He, Ling Cai, Jian Jin, Alan J. Tackett, Deyou Zheng, Gang Greg Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The fusion gene ZMYND11-MBTD1 (ZM) is present in a subgroup of patients with acute myeloid leukaemia (AML). Here, the authors show that ZM expression induces AML in a murine model though activating the NuA4/TIP60 histone acetyltransferase complex.
Externí odkaz:
https://doaj.org/article/cdcc2ab94850477c835abe99c9bfa857
Autor:
Yi Zhang, Yiran Guo, Sheryl M. Gough, Jinyong Zhang, Kendra R. Vann, Kuai Li, Ling Cai, Xiaobing Shi, Peter D. Aplan, Gang Greg Wang, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of AML. Here, the authors report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and provide evidence of a direct link between the associati
Externí odkaz:
https://doaj.org/article/e4bca98ea1b04bc8b103565804db9ae0