Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ganesh Umapathy"'
Autor:
Sanjay Kumar Sukumar, Vimala Antonydhason, Linnea Molander, Jawdat Sandakly, Malak Kleit, Ganesh Umapathy, Patricia Mendoza-Garcia, Tafheem Masudi, Andreas Schlosser, Dick R Nässel, Christian Wegener, Margret Shirinian, Ruth H Palmer
Publikováno v:
eLife, Vol 12 (2024)
Numerous roles for the Alk receptor tyrosine kinase have been described in Drosophila, including functions in the central nervous system (CNS), however the molecular details are poorly understood. To gain mechanistic insight, we employed Targeted Dam
Externí odkaz:
https://doaj.org/article/dfd88ed48fda4c0e92b123d709909f88
Autor:
Anna Djos, Ketan Thombare, Roshan Vaid, Jennie Gaarder, Ganesh Umapathy, Susanne E. Reinsbach, Kleopatra Georgantzi, Jakob Stenman, Helena Carén, Torben Ek, Tanmoy Mondal, Per Kogner, Tommy Martinsson, Susanne Fransson
Publikováno v:
Cancers, Vol 15, Iss 24, p 5732 (2023)
Tumor cells are hallmarked by their capacity to undergo unlimited cell divisions, commonly accomplished either by mechanisms that activate TERT or through the alternative lengthening of telomeres pathway. Neuroblastoma is a heterogeneous pediatric ca
Externí odkaz:
https://doaj.org/article/08d1934b22744e8c89ebcee8c580636e
Autor:
Joanna Szydzik, Dan E. Lind, Badrul Arefin, Yeshwant Kurhe, Ganesh Umapathy, Joachim Tetteh Siaw, Arne Claeys, Jonatan L. Gabre, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Effective therapeutic options are still needed in neuroblastoma treatment. Here, the authors, through a comprehensive proteomics analysis, identify ATR as a potential therapeutic target of neuroblastoma and demonstrate the efficacy of the ATR inhibit
Externí odkaz:
https://doaj.org/article/06e9a92a8a164615981fa91b32e6d409
Autor:
Muhammad Wasi Alam, Marcus Borenäs, Dan E. Lind, Diana Cervantes-Madrid, Ganesh Umapathy, Ruth H. Palmer, Bengt Hallberg
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Oncogenic receptor tyrosine kinases including anaplastic lymphoma kinase (ALK) are implicated in numerous solid and hematologic cancers. ALK mutations are reported in an estimated 9% of neuroblastoma and recent reports indicate that the percentage of
Externí odkaz:
https://doaj.org/article/7faf8d3a4d8d4609a56517ec10e415e2
Autor:
Jikui Guan, Ganesh Umapathy, Yasuo Yamazaki, Georg Wolfstetter, Patricia Mendoza, Kathrin Pfeifer, Ateequrrahman Mohammed, Fredrik Hugosson, Hongbing Zhang, Amy W Hsu, Robert Halenbeck, Bengt Hallberg, Ruth H Palmer
Publikováno v:
eLife, Vol 4 (2015)
Aberrant activation of anaplastic lymphoma kinase (ALK) has been described in a range of human cancers, including non-small cell lung cancer and neuroblastoma (Hallberg and Palmer, 2013). Vertebrate ALK has been considered to be an orphan receptor an
Externí odkaz:
https://doaj.org/article/2218d2495c9e4a558a123f4bb2b6ef16
Autor:
Tzu-Po Chuang, Wei-Yun Lai, Jonatan L. Gabre, Dan E. Lind, Ganesh Umapathy, Abdulmalik A. Bokhari, Bengt Bergman, Linnea Kristenson, Fredrik B. Thorén, Anh Le, Robert Doebele, Jimmy V. Eynden, Ruth H. Palmer, Bengt Hallberg
Publikováno v:
Cancer Research. 83:3936-3936
Anaplastic lymphoma kinase (ALK) fusion variants in non-small-cell-lung cancer (NSCLC) consist of numerous dimerising fusion partners, with the most common being EML4. Clinical data suggests that the degree of treatment benefit in response to ALK tyr
Autor:
Diana, Treis, Ganesh, Umapathy, Susanne, Fransson, Jikui, Guan, Patricia, Mendoza-García, Joachim T, Siaw, Sandra, Wessman, Lena, Gordon Murkes, Jakob J E, Stenman, Anna, Djos, Lotta H M, Elfman, John Inge, Johnsen, Bengt, Hallberg, Ruth H, Palmer, Tommy, Martinsson, Per, Kogner
Publikováno v:
JCO precision oncology. 6
Autor:
Ruth H. Palmer, Joachim T. Siaw, Badrul Arefin, Yeshwant Kurhe, Jimmy Van den Eynden, Arne Claeys, Ganesh Umapathy, Bengt Hallberg, Jonatan L Gabre, Joanna Szydzik, Dan E. Lind
Publikováno v:
NATURE COMMUNICATIONS
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
High-risk neuroblastoma (NB) often involves MYCN amplification as well as mutations in ALK. Currently, high-risk NB presents significant clinical challenges, and additional therapeutic options are needed. Oncogenes like MYCN and ALK result in increas
Autor:
SK Sukumar, Johannes Fuchs, Georg Wolfstetter, Vimala Anthonydhason, Linnea Molander, Ezgi Uçkun, Ruth H. Palmer, Ganesh Umapathy
Publikováno v:
Journal of molecular biology. 433(23)
Anaplastic lymphoma kinase (Alk) is an evolutionary conserved receptor tyrosine kinase belonging to the insulin receptor superfamily. In addition to its well-studied role in cancer, numerous studies have revealed that Alk-signaling is associated with
Autor:
Tafheem A Masudi, Wei-Yun Lai, Barbara Witek, Jikui Guan, Arne Claeys, Jimmy Van den Eynden, Marcus Borenäs, Abeer El Wakil, Jan Koster, Dan E. Lind, Jennie Gaarder, Bengt Hallberg, Mathias Johansson, Patricia Mendoza-Garcia, Badrul Arefin, Ganesh Umapathy, Tzu-Po Chuang, Susanne Fransson, Ruth H. Palmer
Publikováno v:
EMBO JOURNAL
The EMBO Journal
EMBO journal, 40(3):e105784. Wiley-Blackwell
The EMBO Journal
EMBO journal, 40(3):e105784. Wiley-Blackwell
High‐risk neuroblastoma (NB) is responsible for a disproportionate number of childhood deaths due to cancer. One indicator of high‐risk NB is amplification of the neural MYC (MYCN) oncogene, which is currently therapeutically intractable. Identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c899515cacb2806e0ab2b680fe6846df
https://biblio.ugent.be/publication/8686831
https://biblio.ugent.be/publication/8686831