Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ganesh S. Pedgaonkar"'
Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors
Autor:
Manoj Chandran, Janupally Renuka, Jonnalagadda Padma Sridevi, Ganesh S Pedgaonkar, Vanaparthi Asmitha, Perumal Yogeeswari, Dharmarajan Sriram
Publikováno v:
International Journal of Mycobacteriology, Vol 4, Iss 2, Pp 104-115 (2015)
Background and objectives: Bacterial DNA topoisomerases are unique in maintaining the DNA topology for cell viability. Mycobacterium tuberculosis (MTB) DNA gyrase, a sole type II topoisomerase has a larger scope as a target for developing novel thera
Externí odkaz:
https://doaj.org/article/75ea5bd0e2334e23a8d2f38b31482be6
Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors
Autor:
Ganesh S. Pedgaonkar, Perumal Yogeeswari, Dharmarajan Sriram, Janupally Renuka, Vanaparthi Asmitha, Jonnalagadda Padma Sridevi, Manoj Chandran
Publikováno v:
International Journal of Mycobacteriology, Vol 4, Iss 2, Pp 104-115 (2015)
Background and objectives Bacterial DNA topoisomerases are unique in maintaining the DNA topology for cell viability. Mycobacterium tuberculosis (MTB) DNA gyrase, a sole type II topoisomerase has a larger scope as a target for developing novel therap
Autor:
Subhas S. Karki, Chitra G. Rajput, Ganesh S. Pedgaonkar, Girish S. Shendarkar, P. K. Zubaidha, Santosh Ramarao Bhutle, Rizwan M. Shaikh
Publikováno v:
Medicinal Chemistry Research. 20:1158-1163
The phytoalexin 3,5,4′-trihydroxy-trans-stilbene (resveratrol) has attracted considerable attention from biologists and chemists due to its diverse biological properties. Owing to the biological importance of this compound, we have synthesized new
Autor:
Jonnalagadda Padma Sridevi, Dharmarajan Sriram, Ganesh S. Pedgaonkar, Perumal Yogeeswari, Variam Ullas Jeankumar, Shailendra K. Saxena, Janupally Renuka, Parthiban Brindha Devi
Publikováno v:
European journal of medicinal chemistry. 86
InhA, the enoyl acyl carrier protein reductase of Mycobacterium tuberculosis (MTB) is an attractive target for developing novel anti-tubercular agents. Twenty eight 2-(4-oxoquinazolin-3(4H)-yl)acetamide derivatives were synthesized and evaluated for
Autor:
Shailendra K. Saxena, Janupally Renuka, Variam Ullas Jeankumar, Perumal Yogeeswari, Ganesh S. Pedgaonkar, Parthiban Brindha Devi, Jonnalagadda Padma Sridevi, Dharmarajan Sriram
Publikováno v:
Bioorganicmedicinal chemistry. 22(21)
A series of twenty seven substituted 2-(2-oxobenzo[d]oxazol-3(2H)-yl)acetamide derivatives were designed based on our earlier reported Mycobacterium tuberculosis (MTB) enoyl-acyl carrier protein reductase (InhA) lead. Compounds were evaluated for MTB