Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ganesh Routholla"'
Autor:
Anurag Kumar Gautam, Pranesh Kumar, Biswanath Maity, Ganesh Routholla, Balaram Ghosh, Kumarappan Chidambaram, M. Yasmin Begum, Adel Al Fatease, P.S. Rajinikanth, Sanjay Singh, Sudipta Saha, Vijayakumar M. R.
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Hepatocellular carcinoma (HCC) is a common malignancy which affects a substantial number of individuals all over the globe. It is the third primary cause of death among persons with neoplasm and has the fifth largest mortality rate among men and the
Externí odkaz:
https://doaj.org/article/a15ae40f256a4f07917f28ea4e7a3fc1
Autor:
Trivedi, Prakruti, Adhikari, Nilanjan, Amin, Sk. Abdul, Bobde, Yamini, Ganesh, Routholla, Jha, Tarun, Ghosh, Balaram
Publikováno v:
In European Journal of Pharmaceutical Sciences 1 October 2019 138
Autor:
Sanjib Das, Tarun Jha, Ganesh Routholla, Balaram Ghosh, Nilanjan Adhikari, Sk. Abdul Amin, Dhanya Vijayasarathi, Prakruti Trivedi
Publikováno v:
New Journal of Chemistry. 45:17149-17162
Histone deacetylase 8 (HDAC8) has been implicated as a potential drug target of many diseases including cancer. HDAC8 isoform selectivity over other class-I HDACs is a major concern nowadays. In this work, a series of pentanoic acid based hydroxamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0117affcee6b5e2772da8bf0a9387598
https://doi.org/10.1039/d1nj02636d
https://doi.org/10.1039/d1nj02636d
Autor:
Kavitha, Sedmaki, Kalyani, Karnam, Pravesh, Sharma, Ashutosh, Mahale, Ganesh, Routholla, Balaram, Ghosh, Onkar, Prakash Kulkarni
Publikováno v:
International Immunopharmacology. 110:108919
Pathogenesis of acute kidney injury is driven by necro-inflammation, which is comprised of IL-1β mediated inflammation and RIP-1 mediated tubular necroptosis. HDAC6 is reported to regulate both inflammation and cell death. In the present study, we e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4beea4ae80c5bd91a490d7b3f1b083
https://doi.org/10.1016/j.intimp.2022.108919
https://doi.org/10.1016/j.intimp.2022.108919
Autor:
Sravani Pulya, Tarun Patel, Milan Paul, Nilanjan Adhikari, Suvankar Banerjee, Ganesh Routholla, Swati Biswas, Tarun Jha, Balaram Ghosh
Publikováno v:
European Journal of Medicinal Chemistry. 238:114470
A promising hydrazide based small molecule lead as a potent and selective histone deacetylase 3 (HDAC3) inhibitor has been developed from a small series of synthesized novel chemical entities. The lead compound (4e) displayed high HDAC3 inhibitory po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af5ffd75e63adcbaac3c5f6ba4db37e
https://doi.org/10.1016/j.ejmech.2022.114470
https://doi.org/10.1016/j.ejmech.2022.114470
Autor:
Yamini Bobde, Ganesh Routholla, Swati Biswas, Sravani Pulya, Vivek Sharma, Ashutosh Mahale, Swati, Balaram Ghosh, Onkar P. Kulkarni, Tarun Patel
Publikováno v:
ACS chemical neuroscience. 12(5)
The importance of HDAC3 in transcriptional regulation of genes associated with long-term memory is well established. Here, we report a novel HDAC3 inhibitor, PT3, with an excellent blood-brain barrier permeability and ability to enhance long-term mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d88ea8949ee7048b9570d207f885aa
https://pubmed.ncbi.nlm.nih.gov/33577290
https://pubmed.ncbi.nlm.nih.gov/33577290
Autor:
Tarun Jha, Nilanjan Adhikari, Sravani Pulya, Milan Paul, Tarun Patel, Balaram Ghosh, Srividya Bhagavatula, Swati Biswas, Ganesh Routholla, Sk. Abdul Amin
Publikováno v:
Bioorganic Chemistry. 117:105446
Histone deacetylase 3 (HDAC3) is one of the most promising targets to develop anticancer therapeutics. In continuation of our quest for selective HDAC3 inhibitors, a series of small molecules having o-hydroxy benzamide as the novel zinc binding group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6d19671a4c75c8c861aa8d95cad4d1
https://doi.org/10.1016/j.bioorg.2021.105446
https://doi.org/10.1016/j.bioorg.2021.105446
Autor:
Tarun Jha, Nilanjan Adhikari, Swati Biswas, Ganesh Routholla, Sk. Abdul Amin, Balaram Ghosh, Sravani Pulya, Tarun Patel
Publikováno v:
Bioorganic Chemistry. 114:105050
A series of novel linker-less benzamides with different aryl and heteroaryl cap groups have been designed, synthesized, and screened as potent histone deacetylase (HDAC) inhibitors with promising anticancer activity. Two lead compounds 5e and 5f were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b7b872e878a9a875aeca96ddfd0700
https://doi.org/10.1016/j.bioorg.2021.105050
https://doi.org/10.1016/j.bioorg.2021.105050
Autor:
Kalyani Karnam, Sriharshini Goli, Onkar P. Kulkarni, Kavitha Sedmaki, Venkata Vamsi Krishna Venuganti, Ganesh Routholla, Pravesh Sharma, Balaram Ghosh
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1866(11)
Delayed wound healing in diabetes is characterized by sustained activation of inflammasome and increased expression of IL-1β in macrophages. Identification and validation of novel pathways to regulate IL-1β expression will provide therapeutic targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c465fd34c6517ccb515bc1d582be21c4
https://pubmed.ncbi.nlm.nih.gov/32712153
https://pubmed.ncbi.nlm.nih.gov/32712153
Publikováno v:
Tetrahedron. 76:131262
A simple and convenient method for the synthesis of α-ketoamides by the oxidation of aryl acetamides using potassium superoxide (KO2) as an oxidizing agent is disclosed here. The scope of the developed method is successfully tested with fifteen subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bb76bc4dc39f4da12115a9b2a883860
https://doi.org/10.1016/j.tet.2020.131262
https://doi.org/10.1016/j.tet.2020.131262