Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ganesh L.R. Lokesh"'
Autor:
Pinar Kanlikilicer, Bulent Ozpolat, Burcu Aslan, Recep Bayraktar, Nilgun Gurbuz, Cristian Rodriguez-Aguayo, Emine Bayraktar, Merve Denizli, Vianey Gonzalez-Villasana, Cristina Ivan, Ganesh L.R. Lokesh, Paola Amero, Silvia Catuogno, Monika Haemmerle, Sherry Yen-Yao Wu, Rahul Mitra, David G. Gorenstein, David E. Volk, Vittorio de Franciscis, Anil K. Sood, Gabriel Lopez-Berestein
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 251-262 (2017)
Despite substantial improvements in the treatment strategies, ovarian cancer is still the most lethal gynecological malignancy. Identification of drug treatable therapeutic targets and their safe and effective targeting is critical to improve patient
Externí odkaz:
https://doaj.org/article/30d18358dbe6414f995427ef4aed9541
Autor:
Cristian Rodriguez-Aguayo, Yasmin M. Attia, Ganesh L.R. Lokesh, Shuxing Zhang, Vittorio Cristini, Anil K. Sood, Rahul Mitra, Gabriel Lopez-Berestein, Abdelrahman M. Elsayed, Vittorio de Franciscis, David E. Volk, Paola Amero, Cristina Ivan, Rajan Chaudhari, Roberto Cardenas-Zuniga, Thomas J. S. Schubert, Efigenia Montalvo-González, Zhihui Wang
Publikováno v:
Journal of the American Chemical Society. 143(20)
Aptamers, synthetic single-strand oligonucleotides that are similar in function to antibodies, are promising as therapeutics because of their minimal side effects. However, the stability and bioavailability of the aptamers pose a challenge. We develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fd20c040fe70bad47dab05aa255ce5
https://pubmed.ncbi.nlm.nih.gov/33988982
https://pubmed.ncbi.nlm.nih.gov/33988982
Autor:
Consuelo Walss-Bass, Ganesh L.R. Lokesh, Elena Dyukova, David G. Gorenstein, Dawn I. Velligan, David E. Volk, David L. Roberts
Publikováno v:
Complex Psychiatry. 5:52-59
The field of proteomics is rapidly gaining territory as a promising alternative to genomic approaches in the efforts to unravel the complex molecular mechanisms underlying schizophrenia and other psychiatric disorders. X-aptamer technology has emer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed0ca74deed034f938aac6bea7ee5bb
https://doi.org/10.1159/000492331
https://doi.org/10.1159/000492331
Autor:
Anil K. Sood, Xin Li, Miguel Angel Elizondo-Riojas, Alpa M. Nick, David G. Gorenstein, David E. Volk, Ganesh L.R. Lokesh, Kevin P. Rosenblatt, Li Li, Hongyu Wang
Publikováno v:
BioTechniques. 61:249-259
High affinity aptamer-based biomarker discovery has the advantage of simultaneously discovering an aptamer affinity reagent and its target biomarker protein. Here, we demonstrate a morphology-based tissue aptamer selection method that enables us to u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2cefe285376f335783bec8cedd9981
https://doi.org/10.2144/000114473
https://doi.org/10.2144/000114473
Autor:
Inna Chervoneva, Takemi Tanaka, Yuji Kondo, Natalie Hills, Hallgeir Rui, Macall Leslie, Norihisa Ichimura, David G. Gorenstein, David E. Volk, Rachel Davis, Hiroyasu Kameyama, Yoshihiro Morita, Ganesh L.R. Lokesh, Roy Zhang, Nafis Hasan
Publikováno v:
Cancers
Volume 12
Issue 3
Cancers, Vol 12, Iss 3, p 725 (2020)
Volume 12
Issue 3
Cancers, Vol 12, Iss 3, p 725 (2020)
Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45+ immune cell density adjacent to E-selectin expressing inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9de7ba805ddf1f432e41b074412d65
https://doi.org/10.3390/cancers12030725
https://doi.org/10.3390/cancers12030725
Autor:
Cristina Ivan, Xinna Zhang, Sunila Pradeep, Dahai Jiang, Monika Haemmerle, Kshipra M. Gharpure, Takemi Tanaka, Sourindra Maiti, David G. Gorenstein, Rajesha Rupaimoole, Ganesh L.R. Lokesh, Sherry Y. Wu, Hongyu Wang, Archana S. Nagaraja, Gabriel Lopez-Berestein, Lingegowda S. Mangala, Anil K. Sood, Nataliya Bulayeva, Cristian Rodriguez-Aguayo, David E. Volk, Emine Bayraktar, Xin Li, Hyun Jin Choi, Xianbin Yang, Varatharasa Thiviyanathan, Recep Bayraktar, Laurence J.N. Cooper, Wei Hu, Kevin P. Rosenblatt, Li Li, Michael McGuire, Anoma Somasunderam, Piotr L. Dorniak
Publikováno v:
JCI Insight, Vol 6, Iss 7 (2021)
JCI Insight
JCI Insight
Current antiangiogenesis therapy relies on inhibiting newly developed immature tumor blood vessels and starving tumor cells. This strategy has shown transient and modest efficacy. Here, we report a better approach to target cancer-associated endothel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8ee60630c436cd0a8c292c5db743a7
https://europepmc.org/articles/PMC6124393/
https://europepmc.org/articles/PMC6124393/
Publikováno v:
Molecules; Volume 22; Issue 8; Pages: 1355
Molecules, Vol 22, Iss 8, p 1355 (2017)
Molecules, Vol 22, Iss 8, p 1355 (2017)
NMR spectroscopy is a powerful tool for research on protein dynamics. In the past decade, there has been significant progress in the development of NMR methods for studying charged side chains. In particular, NMR methods for lysine side-chain NH3+ gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aef3ccbc6921db7b338c576a9747825
Autor:
Ganesh L.R. Lokesh, Varatharasa Thiviyanathan, David E. Volk, Hongyu Wang, Nancy E. Ward, Curtis H. Lam, David G. Gorenstein
Publikováno v:
RNA Nanostructures ISBN: 9781493971374
Aptamers and second generation analogs, such as X-Aptamers (XAs), SOMAmers, locked nucleic acids (LNAs), and others are increasingly being used for molecular pathway targeting, biomarker discovery, or disease diagnosis by interacting with protein tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84aa4bc4d0a8877102f78ad9e51139b0
https://doi.org/10.1007/978-1-4939-7138-1_10
https://doi.org/10.1007/978-1-4939-7138-1_10
Autor:
Ganesh L.R. Lokesh, Muniasamy Neerathilingam, Anoma Somasunderam, Varatharasa Thiviyanathan, Jim Klostergaard, Takemi Tanaka, Mauro Ferrari, Xin Li, Yang Peng, David G. Gorenstein, Aman P. Mann
Publikováno v:
Biochemistry. 49:9106-9112
CD44, the primary receptor for hyaluronic acid, plays an important role in tumor growth and metastasis. CD44-hyaluronic acid interactions can be exploited for targeted delivery of anticancer agents specifically to cancer cells. Although various splic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f0e6d175f45214bae43034d3dd2c92
https://doi.org/10.1021/bi1009503
https://doi.org/10.1021/bi1009503
Autor:
Shu Zhang, Paola Amero, Cristina Ivan, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Emine Bayraktar, David E. Volk, Anil K. Sood, Rajan Chaudhari, Ganesh L.R. Lokesh
Publikováno v:
Annals of Oncology. 29:iii17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6646eeb7331806abb278a374a41998
https://doi.org/10.1093/annonc/mdy047.029
https://doi.org/10.1093/annonc/mdy047.029