Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ganesh E. Phad"'
Autor:
Martin M. Corcoran, Ganesh E. Phad, Néstor Vázquez Bernat, Christiane Stahl-Hennig, Noriyuki Sumida, Mats A.A. Persson, Marcel Martin, Gunilla B. Karlsson Hedestam
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Current databases of V genes for antibody repertoire have limitations. Here Corcoran et al. develop a computational approach named IgDiscover that can identify germline V gene sequences from expressed antibody repertoires to high specificity and comp
Externí odkaz:
https://doaj.org/article/8347676fcb7f429d81b27ddb94c2bdb4
Autor:
Néstor Vázquez Bernat, Martin Corcoran, Uta Hardt, Mateusz Kaduk, Ganesh E. Phad, Marcel Martin, Gunilla B. Karlsson Hedestam
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Next generation sequencing (NGS) of immunoglobulin (Ig) repertoires (Rep-seq) enables examination of the adaptive immune system at an unprecedented level. Applications include studies of expressed repertoires, gene usage, somatic hypermutation levels
Externí odkaz:
https://doaj.org/article/7a61cba5d1514f6bb3b5837af43eb308
Autor:
Ganesh E. Phad, Dora Pinto, Mathilde Foglierini, Murodzhon Akhmedov, Riccardo L. Rossi, Emilia Malvicini, Antonino Cassotta, Chiara Silacci Fregni, Ludovica Bruno, Federica Sallusto, Antonio Lanzavecchia
Publikováno v:
Nature Immunology, 23 (7)
Memory B cells persist for a lifetime and rapidly differentiate into antibody-producing plasmablasts and plasma cells upon antigen re-encounter. The clonal relationship and evolution of memory B cells and circulating plasmablasts is not well understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601f56584cd51973af7ddf6f63371491
Autor:
Kelly K. Lee, Paola Martinez-Murillo, S. Aljedani, Pradeepa Pushparaj, Sijy O'Dell, Rachel Kinzelman, Tyler J. Liban, John R. Mascola, Viktoriya Dubrovskaya, Gunilla B. Karlsson Hedestam, Ganesh E. Phad, Richard T. Wyatt, Justas Rodarte, Marie Pancera, Alexander Mileant, Vidya Mangala Prasad, Karen Tran, Suruchi Singh
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009543 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009543 (2021)
Understanding the molecular mechanisms by which antibodies target and neutralize the HIV-1 envelope glycoprotein (Env) is critical in guiding immunogen design and vaccine development aimed at eliciting cross-reactive neutralizing antibodies (NAbs). H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f0ea264ec651dba30d7e2477929fd7
https://pubmed.ncbi.nlm.nih.gov/34559844
https://pubmed.ncbi.nlm.nih.gov/34559844
Autor:
Komal Bhullar, Sanjana Narang, Suruchi Singh, Richard T. Wyatt, Benjamin Murrell, Karen Tran, Sijy O'Dell, Gunilla B. Karlsson Hedestam, Lawrence Shapiro, John R. Mascola, Néstor Vázquez Bernat, Christopher Sundling, Gilman Dionne, Marcel Martin, Chiara Sorini, Pradeepa Pushparaj, Ganesh E. Phad, Martin Corcoran, Marie Pancera, Paola Martinez-Murillo, Viktoriya Dubrovskaya, Eduardo J. Villablanca, Monika Adori
Publikováno v:
The Journal of Experimental Medicine
HIV-1 is an exceptionally difficult vaccine target, and only certain types of antibodies are effective. Vaccination induces antibodies that bind the virus with different efficiencies. This study investigates this process and reveals how the immune sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6892e3046bcac5d89fe313332d46e15
https://doi.org/10.1084/jem.20191155
https://doi.org/10.1084/jem.20191155
Autor:
Mateusz Kaduk, Martin Corcoran, Uta Hardt, Marcel Martin, Néstor Vázquez Bernat, Gunilla B. Karlsson Hedestam, Ganesh E. Phad
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Next generation sequencing (NGS) of immunoglobulin (Ig) repertoires (Rep-seq) enables examination of the adaptive immune system at an unprecedented level. Applications include studies of expressed repertoires, gene usage, somatic hypermutation levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6bc319eead92b33f337a510a544b02
https://pubmed.ncbi.nlm.nih.gov/31024532
https://pubmed.ncbi.nlm.nih.gov/31024532
Autor:
Constance Williams, Lilian Nogueira, Ganesh E. Phad, Michel C. Nussenzweig, Susan Zolla-Pazner, Joshua A. Horwitz, Gunilla B. Karlsson Hedestam, Florian Klein, Gerd Fätkenheuer, Clara Lehmann, Michael S. Seaman, Masashi Shingai, Pamela J. Bjorkman, Thomas Eisenreich, Cassie Liu, Ariel Halper-Stromberg, Malcolm A. Martin, Yoshiaki Nishimura, Anthony P. West, Anna Gazumyan
Publikováno v:
The Journal of Experimental Medicine
Klein et al. find that frequently arising antibodies that normally fail to control HIV-1 infection can synergize with passively transferred bNAbs to prevent the emergence of bNAb viral escape variants.
Antibody-mediated immunotherapy is effectiv
Antibody-mediated immunotherapy is effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a645fa38b0f59bdbdf2f661424b46e9
https://doi.org/10.1084/jem.20141050
https://doi.org/10.1084/jem.20141050
Publikováno v:
European Journal of Neuroscience. 40:2513-2526
In Drosophila, serotonin (5-HT) regulates aggression, mating behaviour and sleep/wake behaviour through different receptors. Currently, how these various receptors are themselves regulated is still not completely understood. The KCTD12-family of prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731067510d570ebeec8d9fa5c5a6af17
https://doi.org/10.1111/ejn.12619
https://doi.org/10.1111/ejn.12619
Autor:
Christopher Sundling, Zizhang Sheng, John R. Mascola, Yimeng Wang, Richard T. Wyatt, Lawrence Shapiro, Yuxing Li, Ganesh E. Phad, Gunilla B. Karlsson Hedestam, Zhenhai Zhang
Publikováno v:
The Journal of Immunology. 192:3637-3644
The nonhuman primate model is important for preclinical evaluation of prophylactic and therapeutic intervention strategies. The recent description of the rhesus macaque germline Ig loci and establishment of a database of germline gene segments offer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0f5a635a47226e873ff79e5d0f3a11
https://doi.org/10.4049/jimmunol.1303334
https://doi.org/10.4049/jimmunol.1303334
Autor:
Sebastian Ols, Klara Lenart, Rodrigo Arcoverde Cerveira, Marcos C miranda, Natalie Brunette, Jana Kochmann, Martin Corcoran, Rebecca Skotheim, Annika Philomin, Alberto Cagigi, Brooke Fiala, Samuel Wrenn, Jessica Marcandalli, Fredrika Hellgren, Elizabeth A Thompson, Ang Lin, Florian Gegenfurtner, Azad Kumar, Man Chen, Ganesh E Phad, Barney S Graham, Laurent Perez, Andrew J Borst, Gunilla B Karlsson Hedestam, Tracy J Ruckwardt, Neil P King, Karin Loré
Nanoparticles for multivalent display and delivery of vaccine antigens have emerged as a promising avenue for enhancing B cell responses to protein subunit vaccines. Here, we evaluated B cell responses in rhesus macaques immunized with prefusion stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e5c8c6f65335ccc060c0bcc37b3b1fb