Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Ganesh D. Kini"'
Autor:
Donald F Smee, Howard B Cottam, Brahma S Sharma, Ganesh D Kini, Ganapathi R Revankar, Emmanuel A Ojo-Amaize, Robert W Sidwell, Weldon B Jolley, Roland K Robins
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 3, Iss Suppl B, Pp 41-48 (1992)
7-thia-8-oxoguanosine (TOGuo) is the first reported structure of a family of modified guanosine analogues exhibiting antiviral activity in rodent models. Its spectrum of action includes interferon-sensitive viruses such as alphaviruses, bunyaviruses,
Externí odkaz:
https://doaj.org/article/c4c9e5228dba4f8a9eceddc11c64aceb
Publikováno v:
The Open Microbiology Journal
Staphylococcus warneri does not generally cause serious infections in humans. We report a case of endocarditis in a healthy individual with no known past medical history. S. warneri was identified in her blood cultures and echocardiographic evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7372750cbad0ef1b2f7d2ab7d5ddb1
http://europepmc.org/articles/PMC3024586
http://europepmc.org/articles/PMC3024586
Autor:
Saskia E Hostetler, John W. Mellors, Douglas D. Richman, Karl Y. Hostetler, Hammond Jennifer, Ting-Chao Chou, James R. Beadle, Ganesh D. Kini, Kathy A. Aldern
Publikováno v:
Antiviral Chemistry and Chemotherapy. 11:213-219
Monoalkyl ether lipid analogues of foscarnet (phosphonoformate, PFA) exhibit substantially greater in vitro antiviral activity than unmodified PFA against human immunodeficiency virus type 1 (HIV-1). Our previous studies indicate that the length of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475dc83b636a2337bcc7a7bd23d1d1f3
https://doi.org/10.1177/095632020001100304
https://doi.org/10.1177/095632020001100304
Autor:
Kathy A. Aldern, Douglas D. Richman, Ganesh D. Kini, James R. Beadle, Michael F. Gardner, Karl Y. Hostetler, Kristine N. Wright
Publikováno v:
Antiviral Chemistry and Chemotherapy. 9:33-40
In a previous study, we reported that 1- O-octadecyl- sn-glycero-3-foscarnet (ODG-PFA) was 40 to 93 times more potent than free foscarnet (PFA) in human cytomegalovirus (HCMV)-, herpes simplex virus type 1 (HSV-1)- and human immunodeficiency virus ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c4513ee9dbfafdf8fd1df480e7e860
https://doi.org/10.1177/095632029800900104
https://doi.org/10.1177/095632029800900104
Autor:
James R. Beadle, Kathy A. Aldern, Karl Y. Hostetler, Douglas D. Richman, Hong Xie, Ganesh D. Kini
Publikováno v:
Antiviral Research. 36:43-53
The identification of more effective and less toxic foscarnet (PFA) analogs for antiviral therapy would be useful. We recently synthesized 1-O-octadecyl-sn-glycero-3-phosphonoformic acid (ODG-PFA) and noted a 93-fold increase in its anti-HCMV activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd19d04cff1a43d046dd49aff8316ea
https://doi.org/10.1016/s0166-3542(97)00039-9
https://doi.org/10.1016/s0166-3542(97)00039-9
Autor:
Kristine N. Wright, Brent A. Korba, James R. Beadle, Ganesh D. Kini, Michael F. Gardner, Karl Y. Hostetler, Tong-Hau Wu
Publikováno v:
Biochemical Pharmacology. 53:1815-1822
Acyclovir (ACV) triphosphate and azidothymidine (AZT) triphosphate inhibit the DNA polymerase of human hepatitis B virus (HBV) by 50% at submicromolar concentrations, but no effects of ACV or AZT treatment have been noted on the clinical manifestatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f0282f085942e0ddc1b7d7be99e69f
https://doi.org/10.1016/s0006-2952(97)82446-x
https://doi.org/10.1016/s0006-2952(97)82446-x
Alkylpurines as immunopotentiating agents. Synthesis and antiviral activity of certain alkylguanines
Publikováno v:
Journal of Medicinal Chemistry. 36:3431-3436
Several simple 8-substituted 9-alkyl- and 7,8-disubstituted 9-alkylguanine derivatives were synthesized as potential antiviral agents. These were tested for antiviral protection against a lethal Semliki Forest virus (SFV) infection in mice, and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d35459fd90690e8b6c59348456bc4b7
https://doi.org/10.1021/jm00074a025
https://doi.org/10.1021/jm00074a025
Publikováno v:
ChemInform. 22
C 11 H 15 N 5 O 4 S 2 •H 2 O cristallise dans P2 1 avec a=5,9889, b=20,772, c=6,7374 A, β=113,843 o , Z=2; affinement jusqu'a R=0,0253. La conformation du sucre et les parametres d'empilement sont 2 T 1 , P=149,1 o et τ m =34,8 o . La chaine late
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da6e5e75358e98a9785c3e7b7c904d3d
https://doi.org/10.1002/chin.199120270
https://doi.org/10.1002/chin.199120270
Autor:
Ganesh D. Kini, Elizabeth M. Henry, Steven B. Larson, Roland K. Robins, Donald F. Smee, Hassan A. Alaghamandan
Publikováno v:
ChemInform. 22
2,6,8-Trichloro-7-methylpurine (3) was converted to 2-chloro-8,9-dihydro-7-methyl-8-thioxopurin-6(1H)-one (5) by utilizing the difference in reactivity of the 2-, 6-, and 8-positions in the trichloropurine ring system to nucleophilic displacement. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a098c6950102643d40edac5cbaeda53c
https://doi.org/10.1002/chin.199104326
https://doi.org/10.1002/chin.199104326
Autor:
Howard B. Cottam, Donald F. Smee, Yogesh S. Sanghvi, Roland K. Robins, N. S. Girgis, G. R. Revankar, Arthur F. Lewis, K. Ramasamy, W. B. Jolley, Ganesh D. Kini
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4cffad053a9a608299ec2e3d612b47e
https://doi.org/10.1002/chin.199210318
https://doi.org/10.1002/chin.199210318