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Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity

Autor: Ashton, Trent D., Ngo, Anna, Favuzza, Paola, Bullen, Hayley E., Gancheva, Maria R., Romeo, Ornella, Parkyn Schneider, Molly, Nguyen, Nghi, Steel, Ryan W.J., Duffy, Sandra, Lowes, Kym N., Sabroux, Helene Jousset, Avery, Vicky M., Boddey, Justin A., Wilson, Danny W., Cowman, Alan F., Gilson, Paul R., Sleebs, Brad E.

Publikováno v: In Bioorganic Chemistry December 2021 117

Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion

Autor: Nguyen, William, Dans, Madeline G., Ngo, Anna, Gancheva, Maria R., Romeo, Ornella, Duffy, Sandra, de Koning-Ward, Tania F., Lowes, Kym N., Sabroux, Helene Jousset, Avery, Vicky M., Wilson, Danny W., Gilson, Paul R., Sleebs, Brad E.

Publikováno v: In European Journal of Medicinal Chemistry 15 March 2021 214

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics

Autor: Dans, Madeline G., Piirainen, Henni, Nguyen, William, Khurana, Sachin, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D., Dawson, Aurelie T., Das, Sujaan, Schneider, Molly Parkyn, Jonsdottir, Thorey K., Gabriela, Mikha, Gancheva, Maria R., Tonkin, Christopher J., Mollard, Vanessa, Goodman, Christopher Dean, McFadden, Geoffrey I., Wilson, Danny W., Rogers, Kelly L., Barry, Alyssa E., Crabb, Brendan S., de Koning-Ward, Tania F., Sleebs, Brad E., Kursula, Inari Talvikki, Gilson, Paul R.

Externí odkaz: https://hdl.handle.net/11250/3147584

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics.

Autor: Dans MG; Burnet Institute, Melbourne, Victoria, Australia.; School of Medicine and Institute for Mental and Physical Health and Clinical Translation, Deakin University, Waurn Ponds, Victoria, Australia.; Walter and Eliza Hall Institute, Parkville, Victoria, Australia., Piirainen H; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Nguyen W; Walter and Eliza Hall Institute, Parkville, Victoria, Australia., Khurana S; Walter and Eliza Hall Institute, Parkville, Victoria, Australia., Mehra S; Burnet Institute, Melbourne, Victoria, Australia., Razook Z; Burnet Institute, Melbourne, Victoria, Australia.; School of Medicine and Institute for Mental and Physical Health and Clinical Translation, Deakin University, Waurn Ponds, Victoria, Australia., Geoghegan ND; Walter and Eliza Hall Institute, Parkville, Victoria, Australia., Dawson AT; Walter and Eliza Hall Institute, Parkville, Victoria, Australia., Das S; Ludwig Maximilian University, Faculty of Veterinary Medicine, Munich, Germany., Parkyn Schneider M; Burnet Institute, Melbourne, Victoria, Australia., Jonsdottir TK; Burnet Institute, Melbourne, Victoria, Australia.; Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia., Gabriela M; Burnet Institute, Melbourne, Victoria, Australia.; School of Medicine and Institute for Mental and Physical Health and Clinical Translation, Deakin University, Waurn Ponds, Victoria, Australia., Gancheva MR; Research Centre for Infectious Diseases, The University of Adelaide, Adelaide, Australia., Tonkin CJ; Walter and Eliza Hall Institute, Parkville, Victoria, Australia., Mollard V; School of Biosciences, The University of Melbourne, Parkville, Victoria, Australia., Goodman CD; School of Biosciences, The University of Melbourne, Parkville, Victoria, Australia., McFadden GI; School of Biosciences, The University of Melbourne, Parkville, Victoria, Australia., Wilson DW; Research Centre for Infectious Diseases, The University of Adelaide, Adelaide, Australia., Rogers KL; Walter and Eliza Hall Institute, Parkville, Victoria, Australia., Barry AE; Burnet Institute, Melbourne, Victoria, Australia.; School of Medicine and Institute for Mental and Physical Health and Clinical Translation, Deakin University, Waurn Ponds, Victoria, Australia., Crabb BS; Burnet Institute, Melbourne, Victoria, Australia.; Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia., de Koning-Ward TF; School of Medicine and Institute for Mental and Physical Health and Clinical Translation, Deakin University, Waurn Ponds, Victoria, Australia., Sleebs BE; Walter and Eliza Hall Institute, Parkville, Victoria, Australia., Kursula I; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.; Department of Biomedicine, University of Bergen, Bergen, Norway., Gilson PR; Burnet Institute, Melbourne, Victoria, Australia.; Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia.

Publikováno v: PLoS biology [PLoS Biol] 2023 Apr 13; Vol. 21 (4), pp. e3002066. Date of Electronic Publication: 2023 Apr 13 (Print Publication: 2023).