Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ganapathy Sarma"'
Autor:
Marcin Kowanetz, Shelley Ackerman, David Dornan, Michael Alonso, Edith Perez, Cecelia Pearson, Arthur Lee, Karla Henning, Steven Chapin, LIsa Blum, Angela Luo, Matthew Zhou, Brian Safina, Amreen Husain, William Mallet, Rishali Gadkari, Laughing Bear Torrez Dulgeroff, AAngela Luondrew Luo, Jennifer Melrose, Jess Nolin, Puneet Anand, Ganapathy Sarma, Liz Bogaert, Romas Kudirka, Yuyi Shen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/fb2042523bb947d7be8150b8d9c85ab4
Autor:
Michael A. Schmidt, Chunshan Xie, Naidu S. Chowdari, Ankita G. Niyogi, David R. Langley, Heng Cheng, Gregory D. Vite, Sivakrishna Guturi, Rajappa Vaidyanathan, Sanjeev Gangwar, Ivar M. McDonald, Kishorekumar Kanagavel, Yichen Tan, Prasanna Sivaprakasam, Souvik Rakshit, Chin Pan, Umamaheswararao Kanusu, Martin D. Eastgate, Madhura Deshpande, Somprabha Sidhar, Bin Zheng, Christiana I. Iwuagwu, Michael R. Luzung, Ganapathy Sarma, Kevin M. Peese, Thirumalai Lakshminarasimhan, Patrick G. Holder, Pina M. Cardarelli, Patricia Cho, Srikanth Kotapati, Chetana Rao
Publikováno v:
ACS Med Chem Lett
[Image: see text] A new series with the tetrahydroisoquinoline-fused benzodiazepine (TBD) ring system combined with the surrogates of (1-methyl-1H-pyrrol-3-yl)benzene (“MPB”) payloads were designed and executed for conjugation with a monoclonal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebc8e44bdde09da681c8a7885776a0f
https://doi.org/10.1021/acsmedchemlett.0c00578
https://doi.org/10.1021/acsmedchemlett.0c00578
Autor:
Karla Henning, Yuyi Shen, Jennifer Melrose, David Dornan, AAngela Luondrew Luo, Rishali Gadkari, Michael N. Alonso, Laughing Bear Torrez Dulgeroff, Jess Nolin, Cecelia Pearson, Ganapathy Sarma, Brian Safina, Edith A. Perez, Shelley Erin Ackerman, Liz Bogaert, Arthur Lee, Romas Kudirka, William Mallet, Lisa Blum, Puneet Anand, Angela Luo, Amreen Husain, Steven J. Chapin, Marcin Kowanetz, Matthew Zhou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundCEA (CEACAM5) is a well-validated cell-surface antigen that is highly expressed in multiple solid tumors. Bolt's immune-stimulating antibody conjugates (ISACs) direct a TLR7/8 agonist into tumors to activate tumor-infiltrating myeloid cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4083ed624d53c4e45a44ef917b504cf
https://doaj.org/article/fb2042523bb947d7be8150b8d9c85ab4
https://doaj.org/article/fb2042523bb947d7be8150b8d9c85ab4
Autor:
Lisa K. Blum, Cecelia I. Pearson, Laughing Bear Torrez Dulgeroff, Rishali Gadkari, Angela Luo, Andrew Luo, Jennifer E. Melrose, Jess L. Nolin, Hai Li, Arthur Lee, Matthew N. Zhou, Puneet Anand, Ganapathy Sarma, Karla A. Henning, Steven J. Chapin, Shelley E. Ackerman, Romas Kudirka, Yuyi Shen, Bruce Hug, Edith A. Perez, Marcin Kowanetz, Michael N. Alonso, Brian S. Safina, David Dornan, William G. Mallet
Publikováno v:
Cancer Research. 82:2911-2911
Introduction: Immune-stimulating antibody conjugates (ISACs) direct a TLR7/8 agonist into tumors through engagement of cell surface antigens to activate tumor-associated myeloid cells and initiate a broad innate and adaptive anti-tumor immune respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::050815ec20aebbbb637033acbc3a563a
https://doi.org/10.1158/1538-7445.am2022-2911
https://doi.org/10.1158/1538-7445.am2022-2911
Autor:
Justin A. Kenkel, Rishali Gadkari, Po Y. Ho, Lisa K. Blum, Romas Kudirka, Karla A. Henning, William G. Mallet, Jennifer E. Melrose, Ganapathy Sarma, Steven J. Chapin, Matthew Zhou, Suprit Deol, Cindy Kreder, Yuyi Shen, Bruce Hug, Puneet Anand, Arthur Lee, Hai Li, Shelley E. Ackerman, Brian S. Safina, David Dornan, Michael N. Alonso, Marcin Kowanetz
Publikováno v:
Cancer Research. 82:4252-4252
INTRODUCTION: Immune-stimulating antibody conjugates (ISACs) consist of tumor-targeting antibodies conjugated to immune stimulants and are designed to activate the innate and adaptive immune systems against tumor cells following systemic administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dbf4f693cc6d47982df7afbd2d099b5
https://doi.org/10.1158/1538-7445.am2022-4252
https://doi.org/10.1158/1538-7445.am2022-4252
Autor:
Johnson Walter Lewis, Sung Mei-Chen, Daniel Menezes, Chin Pan, Gregory D. Vite, Yong Zhang, Shrikant Deshpande, Vangipuram S. Rangan, Madhura Deshpande, Richard Rampulla, Ganapathy Sarma, Prasanna Sivaprakasam, Arvind Rajpal, David R. Langley, Tram N. Huynh, Arvind Mathur, Ivar M. McDonald, Naidu S. Chowdari, Pina M. Cardarelli, Bethanne M. Warrack, Srikanth Kotapati, Yichong Wang, Chetana Rao, David Passmore, Robert A. Mate, Robert M. Borzilleri, Sanjeev Gangwar
Publikováno v:
Journal of medicinal chemistry. 63(22)
A series of tetrahydroisoquinoline-based benzodiazepine dimers were synthesized and tested for in vitro cytotoxicity against a panel of cancer cell lines. Structure-activity relationship investigation of various spacers guided by molecular modeling s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92a9ea42e85c4d5cf7895d4d3aa6edc
https://pubmed.ncbi.nlm.nih.gov/33155811
https://pubmed.ncbi.nlm.nih.gov/33155811
Autor:
Rishali Gadkari, Puneet Anand, Shelley Erin Ackerman, Jennifer Melrose, Romas Kudirka, Karla Henning, Ganapathy Sarma, Steven J. Chapin, Matthew Zhou, Arthur Lee, Suprit Deol, Cindy Kreder, Justin A. Kenkel, David Dornan, Marcin Kowanetz, William Mallet, Michael N. Alonso, Brian Safina, Liz Bogaert, Po Ho, Hai Li, Yuyi Shen
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A817-A817
BackgroundPD-L1 is an immune checkpoint that regulates anti-tumor T cell responses and is expressed on tumor cells as well as tumor-infiltrating immune cells across many tumor types. Immune-stimulating antibody conjugates (ISACs) consist of tumor-tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05bd860258c49f32d9032ebdfbb9671d
https://doi.org/10.1136/jitc-2021-sitc2021.782
https://doi.org/10.1136/jitc-2021-sitc2021.782
Autor:
Ronit Ilouz, Randy A. Hall, Issa S. Moody, Banumathi Sankaran, Ganapathy Sarma, Susan S. Taylor, Ryan H. Phan
Publikováno v:
Protein Science. 24:105-116
A-kinase anchoring proteins (AKAPs) regulate cAMP-dependent protein kinase (PKA) signaling in space and time. Dual-specific AKAP2 (D-AKAP2/AKAP10) binds with high affinity to both RI and RII regulatory subunits of PKA and is anchored to transporters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66ed3da26e2bd3301c0ce1500a8337c
https://doi.org/10.1002/pro.2593
https://doi.org/10.1002/pro.2593
Autor:
Cuong D. Tran, Alice Yam, Toni Kline, Gang Yin, Maureen Fitch Bruhns, Venita I. De Almeida, James Zawada, Stellanie Krimm, Mary Rose Masikat, Willy Solis, Ryan Stafford, Joy J. Chen, Sihong Zhou, Jeffrey A. Hanson, Cristina Abrahams, Trevor J. Hallam, Mark Lupher, Tyler H. Heibeck, Ganapathy Sarma, Xiaofan Li, Robert Henningsen, Adam Galan, Alexander Steiner, Krishna Bajjuri, Heather Stephenson
Publikováno v:
Cancer Research. 78:1782-1782
Folate receptor alpha (FolRα) is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in serous and epithelial ovarian cancer, endometrial adenocarcinoma, non-small cell lung cancer and triple negative breast canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d8576c3bba3d8e5128f0a66098c5848
https://doi.org/10.1158/1538-7445.am2018-1782
https://doi.org/10.1158/1538-7445.am2018-1782
Publikováno v:
BMC Pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a96927fe9bf1fb403e39ecef47d1ce
https://doi.org/10.1186/1471-2210-11-s1-o12
https://doi.org/10.1186/1471-2210-11-s1-o12