Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ganapathy Jagatheesan"'
Autor:
Jingjing Zhao, Daniel J. Conklin, Yiru Guo, Xiang Zhang, Detlef Obal, Luping Guo, Ganapathy Jagatheesan, Kartik Katragadda, Liqing He, Xinmin Yin, Md Aminul Islam Prodhan, Jasmit Shah, David Hoetker, Amit Kumar, Vijay Kumar, Michael F. Wempe, Aruni Bhatnagar, Shahid P. Baba
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 12 (2020)
BACKGROUND Myocardial ischemia reperfusion (I/R) injury is associated with complex pathophysiological changes characterized by pH imbalance, the accumulation of lipid peroxidation products acrolein and 4‐hydroxy trans‐2‐nonenal, and the depleti
Externí odkaz:
https://doaj.org/article/563a94ccc330409c9cc8fce3f9f095a1
Autor:
Sujith Dassanayaka, Yuting Zheng, Andrew A. Gibb, Timothy D. Cummins, Lindsey A. McNally, Kenneth R. Brittian, Ganapathy Jagatheesan, Timothy N. Audam, Bethany W. Long, Robert E. Brainard, Steven P. Jones, Bradford G. Hill
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 440-449 (2018)
Pathological cardiac remodeling during heart failure is associated with higher levels of lipid peroxidation products and lower abundance of several aldehyde detoxification enzymes, including aldehyde dehydrogenase 2 (ALDH2). An emerging idea that cou
Externí odkaz:
https://doaj.org/article/26cadb1f9fa54a289fd9b0c378338d7a
Autor:
Matthew A. Nystoriak, Daniel J. Conklin, Detlef Obal, Luping Guo, Joseph David Hoetker, Roberto Bolli, Aruni Bhatnagar, Yiru Guo, Ganapathy Jagatheesan, Peter J. Kilfoil
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 316:H889-H899
Myocardial ischemia-reperfusion (I/R) results in the generation of free radicals, accumulation of lipid peroxidation-derived unsaturated aldehydes, variable angina (pain), and infarction. The transient receptor potential ankyrin 1 (TRPA1) mediates pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea7df045105d57aee829ec2707b5afa
https://doi.org/10.1152/ajpheart.00106.2018
https://doi.org/10.1152/ajpheart.00106.2018
Autor:
Sudarsan Rajan, Natalia Petrashevskaya, Chad M. Warren, Ganapathy Jagatheesan, Tara M. Riddle, R. John Solaro, Stephen B. Liggett, Beata M. Wolska, Brandon J. Biesiadecki, David F. Wieczorek
Publikováno v:
Journal of Biological Chemistry. 294:2913-5835
Phosphorylation of cardiac sarcomeric proteins plays a major role in the regulation of the physiological performance of the heart. Phosphorylation of thin filament proteins, such as troponin I and T, dramatically affects calcium sensitivity of the my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c967aa52d9690804344bbbaf865d01
https://doi.org/10.1074/jbc.ra118.004879
https://doi.org/10.1074/jbc.ra118.004879
Autor:
Yiru Guo, Michael F. Wempe, Liqing He, Xiang Zhang, Ganapathy Jagatheesan, Aruni Bhatnagar, Amit Kumar, Vijay Kumar, Shahid P Baba, Kartik Katragadda, Aminul Islam Prodhan, Xinmin Yin, Jasmit Shah, Jingjing Zhao, David Hoetker, Daniel J. Conklin, Luping Guo, Detlef Obal
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
BACKGROUND Myocardial ischemia reperfusion (I/R) injury is associated with complex pathophysiological changes characterized by pH imbalance, the accumulation of lipid peroxidation products acrolein and 4‐hydroxy trans ‐2‐nonenal, and the deplet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4cd3e8af1dbc211e1db1104974d01df
http://europepmc.org/articles/PMC7429021
http://europepmc.org/articles/PMC7429021
Autor:
Lexiao Jin, Sanjay K. Srivastava, Marina V Malovichko, Aruni Bhatnagar, Whitney S. Theis, Daniel J. Conklin, Pawel Lorkiewicz, Gregg Shirk, Ganapathy Jagatheesan, Andre Richardson, Zhengzhi Xie, Jordan Lynch
Publikováno v:
Toxicol Appl Pharmacol
Although crotonaldehyde (CR) is an abundant α,β-unsaturated aldehyde in mainstream cigarette smoke (MCS), the cardiovascular toxicity of inhaled CR is largely unexplored. Thus, male C57BL/6 J mice were exposed acutely (1 h, 6 h, and 4d) and chronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f438a1c3d38781786fc4fa6fa8bb467a
https://pubmed.ncbi.nlm.nih.gov/32634517
https://pubmed.ncbi.nlm.nih.gov/32634517
Autor:
Daniel J. Conklin, Shubha Ghosh Dastidar, Ganapathy Jagatheesan, Aruni Bhatnagar, Bradford G. Hill, Petra Haberzettl, Jasmit Shah
Hepatic glutathione S-transferases (GSTs) are dysregulated in human obesity, nonalcoholic fatty liver disease, and diabetes. The multifunctional GST pi-isoform (GSTP) catalyzes the conjugation of glutathione with acrolein and inhibits c-Jun NH2-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7c0ce170a4e9dfd5aefc8bb8887dbc
https://europepmc.org/articles/PMC6293160/
https://europepmc.org/articles/PMC6293160/
Autor:
Aruni Bhatnagar, Zhengzhi Xie, Steven P. Jones, Mahavir Singh, Daniel J. Conklin, Deqing Zhang, Michael L. Merchant, Shahid P Baba, Sujith Dassanayaka, Ganapathy Jagatheesan, Jingjing Zhao, Kenneth R. Brittian, Virginia K. Schmidtke
Pathological cardiac hypertrophy is associated with the accumulation of lipid peroxidation-derived aldehydes such as 4-hydroxy-trans-2-nonenal (HNE) and acrolein in the heart. These aldehydes are metabolized via several pathways, of which aldose redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3dc14a3067a16f1d7756cd1869ce52c
https://europepmc.org/articles/PMC6205513/
https://europepmc.org/articles/PMC6205513/
Autor:
Sanjay K. Srivastava, Detlef Obal, Aruni Bhatnagar, Yiru Guo, Jay L. Zweier, D. Gregg Rokosh, Daniel J. Conklin, Luping Guo, Ganapathy Jagatheesan, J. David Hoetker, Sumanth D. Prabhu, Bradford G. Hill, Roberto Bolli, Murugesan Velayutham, Shahid P Baba, Karin Wetzelberger, Daniel W. Riggs, Petra Haberzettl, Russell A. Prough, Peter J. Kilfoil
Publikováno v:
Circulation Research. 117:437-449
Rationale: Myocardial ischemia–reperfusion (I/R) results in the generation of oxygen-derived free radicals and the accumulation of lipid peroxidation–derived unsaturated aldehydes. However, the contribution of aldehydes to myocardial I/R injury h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940181a9eb80b5970f9296acc67a6f2e
https://doi.org/10.1161/circresaha.114.305518
https://doi.org/10.1161/circresaha.114.305518
Redox-sensitive potassium channels consisting of the voltage-gated K+ (KV) channel pore subunit KV1.5 regulate resting membrane potential and thereby contractility of vascular smooth muscle cells. Members of the KV1 family associate with cytosolic au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a140fe451652d6ddbb05e72b78b2fb
https://europepmc.org/articles/PMC5610061/
https://europepmc.org/articles/PMC5610061/