Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Ganapathi R Revankar"'
Autor:
Donald F Smee, Howard B Cottam, Brahma S Sharma, Ganesh D Kini, Ganapathi R Revankar, Emmanuel A Ojo-Amaize, Robert W Sidwell, Weldon B Jolley, Roland K Robins
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 3, Iss Suppl B, Pp 41-48 (1992)
7-thia-8-oxoguanosine (TOGuo) is the first reported structure of a family of modified guanosine analogues exhibiting antiviral activity in rodent models. Its spectrum of action includes interferon-sensitive viruses such as alphaviruses, bunyaviruses,
Externí odkaz:
https://doaj.org/article/c4c9e5228dba4f8a9eceddc11c64aceb
Publikováno v:
Journal of Heterocyclic Chemistry. 28:1779-1788
Several disubstituted pyrazolo[3,4-d]pyrimidine, pyrazolo[1,5-a]pyrimidine and thiazolo[4,5-d]pyrimidine ribonucleosides have been prepared as congeners of uridine and cytidine. Glycosylation of the trimethylsilyl (TMS) derivative of pyrazolo[3,4-d]p
Autor:
Anusch Peyman, Nilabh Chaudhary, T. Sudhakar Rao, Joshua O. Ojwang, Shawn D. Mustain, Eugen Uhlmann, Hélène B. Marshall, Robert F. Rando, Ganapathi R. Revankar, David A. Walker
Publikováno v:
Nucleosides and Nucleotides. 16:1703-1707
Antisense oligonucleotides containing C-5 hexynyl/propynyl modified pyrimidines were synthesized using solid phase phosphoramidite chemistry. These modified oligonucleotides were found to have significant inhibitory activity against TNFα production
Publikováno v:
Journal of Heterocyclic Chemistry. 34:257-262
The preparation of 2-penten-1-yl and 3-methyl-2-buten-1-yl derivatives of adenine 2a,b, 7-deazaadenine 2c,d, 2-aminopurine 4a,b and 5a,b, 4-aminopyrazolo[3,4-d]pyrimidine 7a,b and 7-amino-v-triazolo-[4,5-d]pyrimidine 8a–10a and 8b-10b is described.
Autor:
Raymond F. Schinazi, Jean-Louis Imbach, Lixin Cui, Jean-Pierre Sommadossi, Robert F. Rando, Gilles Gosselin, Ganapathi R. Revankar, Chung K. Chu
Publikováno v:
Biochemical Pharmacology. 52:1577-1584
A group of enantiomeric nucleoside analogues with β- d or β- l configuration, which represent potential candidates for the treatment of hepatitis B virus (HBV) infection, were incubated in human hepato-blastoma HepG2 cells at concentrations between
Synergistic Effect of 5-Nitro-2′-deoxyuridine with Ganciclovir Against Human CytomegalovirusIn Vitro
Publikováno v:
Nucleosides and Nucleotides. 14:1997-2008
In this paper we describe a practical synthesis of 5-nitro-2′-deoxyuridine (4) and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-nitrouracil (11). These compounds were then evaluated for their ability to inhibit the growth of human cytomegalovirus (
Autor:
Ganapathi R. Revankar, T. Sudhakar Rao
Publikováno v:
Nucleosides and Nucleotides. 14:1601-1612
Synthesis of 2-penten-1-yl (8a) and ganciclovir analog (8b) of 1,2,4-triazolo[3,4-f][1,2,4]triazine was accomplished by the ring annulation of the corresponding hydrazides (6a and 6b), which in turn was obtained by the dehydrative coupling of 4 with
Publikováno v:
Nucleosides and Nucleotides. 14:1269-1287
A convenient synthesis of N1-methyl-2′-deoxy-ψ-uridine (ψ-thymidine, ψT, 7a) has been accomplished in good yield. The structural conformation of 7a was derived by 2D NMR and 1D NOE experiments. The nucleoside 7a has been incorporated into G-rich
Autor:
Ganapathi R. Revankar, T. Sudhakar Rao
Publikováno v:
Journal of Heterocyclic Chemistry. 32:1043-1049
Synthesis of alkenyl derivatives of certain purines and purine analogs is described. Direct alkylation of the sodium salt of 6-chloropurine (1) either with 1-bromo-2-pentene or 4-bromo-2-methyl-2-butene in N,N-dimethylformamide furnished N-7, 4a and
Autor:
Nilabh Chaudhary, Ganapathi R. Revankar, V. Bodepudi, T. S. Rao, J. Guy-Caffey, Krishna Jayaraman, Ross H. Durland
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 14:951-955
The ability of simple azole nucleosides to promote antiparallel triplex formation at non-homopurine duplex targets was explored. It was also shown that spermidine-cholesterol conjugation is effective in enhancing cellular uptake and stability of olig