Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Gamze Isitman"'
Autor:
Gamze Isitman, Alexandra Tremblay-McLean, Irene Lisovsky, Julie Bruneau, Bertrand Lebouché, Jean-Pierre Routy, Nicole F Bernard
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164517 (2016)
Natural Killer (NK) cell education, which requires the engagement of inhibitory NK cell receptors (iNKRs) by their ligands, is important for generating self-tolerant functional NK cells. While the potency of NK cell education is directly related to t
Externí odkaz:
https://doaj.org/article/e11e9a9307594d6d8adaf1d4a7d3e651
Autor:
Gamze Isitman, Nicole F. Bernard, Louise Gilbert, Sanket Kant, Irene Lisovsky, Alexandra Tremblay-McLean, Zahra Kiani, Julie Bruneau, Bertrand Lebouché, Franck P. Dupuy, Naglaa H. Shoukry
Publikováno v:
Journal of Leukocyte Biology
The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA ligands do not override them. Abs bound to target cells can also activate NK cells by engag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac34f59a6d2d5ff746afa7d8444d735
http://europepmc.org/articles/PMC6916277
http://europepmc.org/articles/PMC6916277
Publikováno v:
Advances in Virology, Vol 2012 (2012)
The HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants. It is now also clear that NK cells can als
Externí odkaz:
https://doaj.org/article/ac3be96b0bd4413a974f91c068cd29f6
Autor:
Leia Wren, Matthew S Parsons, Gamze Isitman, Robert J Center, Anthony D Kelleher, Ivan Stratov, Nicole F Bernard, Stephen J Kent
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38580 (2012)
There is growing interest in HIV-specific antibody-dependent cellular cytotoxicity (ADCC) as an effective immune response to prevent or control HIV infection. ADCC relies on innate immune effector cells, particularly NK cells, to mediate control of v
Externí odkaz:
https://doaj.org/article/baa29293935045dd89fe734dc2191280
Autor:
Julie Bruneau, Colin Kovacs, Jean-Pierre Routy, Alexandra Tremblay-McLean, Irene Lisovsky, Mark A. Wainberg, Gamze Isitman, Cécile Tremblay, Nicole F. Bernard, Marianne Harris
Publikováno v:
AIDS Research and Human Retroviruses. 32:1079-1088
Carriage of alleles encoding certain inhibitory natural killer (NK) cell receptor/HLA ligand KIR3DL1/HLA-B combinations is associated with protection from HIV infection and slow time to AIDS, implicating NK cells in HIV control. NK cells also mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc01fe0d3afd0569a516bec287feeae
https://doi.org/10.1089/aid.2016.0157
https://doi.org/10.1089/aid.2016.0157
Autor:
Gamze Isitman, Julie Bruneau, Irene Lisovsky, Jean-Pierre Routy, Sandrina DaFonseca, Bertrand Lebouché, Alexandra Tremblay-McLean, Rujun Song, Nicole F. Bernard
Publikováno v:
Journal of Virology. 89:9909-9919
Epidemiological and functional studies implicate NK cells in HIV control. However, there is little information available on which NK cell populations, as defined by the inhibitory NK cell receptors (iNKRs) they express, respond to autologous HIV-infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3ce65ef1d0a3419990ba33b88e436d
https://doi.org/10.1128/jvi.01546-15
https://doi.org/10.1128/jvi.01546-15
Publikováno v:
Journal of Leukocyte Biology. 97:761-767
HLA-null cell lines [721.221 (henceforth, 721) and K562] are often used to study NK cell activation. NK cells are innate immune lymphocytes that express a variety of stochastically expressed inhibitory and activating receptors. Although it is known t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e675b709ab2c8a4e431c3973c496fd
https://doi.org/10.1189/jlb.4ab1014-499r
https://doi.org/10.1189/jlb.4ab1014-499r
Autor:
Gamze Isitman, Marjon Navis, Ivan Stratov, Vijaya Madhavi, Robert De Rose, Stephen J. Kent, Amy W. Chung, Leia Wren
Publikováno v:
Human Vaccines & Immunotherapeutics. 9:1011-1018
HIV-specific ADCC antibodies could play a role in providing protective immunity. We have developed a whole blood ADCC assay that measures NK cell activation in response to HIV peptide epitopes. These HIV peptide-specific ADCC responses are associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79faa67e82f38073b45315ced04e1813
https://doi.org/10.4161/hv.23446
https://doi.org/10.4161/hv.23446
Autor:
Irene Lisovsky, B. Lebouchẻ, Gamze Isitman, Jean-Pierre Routy, Nicole F. Bernard, Julie Bruneau, Alexandra Tremblay-McLean, Rujun Song, S. DaFonseca
Publikováno v:
Clinical and experimental immunology. 186(3)
Summary Carriage of certain inhibitory natural killer (NK) cell receptor (iNKR)/HLA ligand pairs is associated with protection from infection and slow time to AIDS implicating NK cells in HIV control. NK cells acquire functional potential through edu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33dd53317dcd8cc00ba668c9a57d2d7
https://pubmed.ncbi.nlm.nih.gov/27506421
https://pubmed.ncbi.nlm.nih.gov/27506421
Autor:
Gregor F Lichtfuss, Marit Kramski, Gamze Isitman, Grant Rawlin, Damian F. J. Purcell, Anthony Jaworowski, Stephen J. Kent, Marjon Navis, Leia Wren
Publikováno v:
European Journal of Immunology. 42:2771-2781
Antibodies with antibody-dependent cellular cytotoxicity (ADCC) activity play an important role in protection against HIV-1 infection, but generating sufficient amounts of antibodies to study their protective efficacy is difficult. HIV-specific IgG c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c890f1f42c8974129307d89f592dedb
https://doi.org/10.1002/eji.201242469
https://doi.org/10.1002/eji.201242469