Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Gamze B. Bulut"'
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2765-2778 (2023)
Abstract Neutrophil elastase (NE), a major inflammatory mediator in chronic obstructive pulmonary disease (COPD) airways, impairs macrophage function, contributing to persistence of airway inflammation. We hypothesized that NE activates a novel mecha
Externí odkaz:
https://doaj.org/article/455aa25e4811495d8577d01ba67a07b3
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4265 (2024)
Neutrophil elastase (NE) is taken up by macrophages, retains intracellular protease activity, and induces a pro-inflammatory phenotype. However, the mechanism of NE-induced pro-inflammatory polarization of macrophages is not well understood. We hypot
Externí odkaz:
https://doaj.org/article/7a427c183ec043e48b42d0c94dff655f
Autor:
Paul A. Dutchak, Sunil Laxman, Sandi Jo Estill, Chensu Wang, Yun Wang, Yiguang Wang, Gamze B. Bulut, Jinming Gao, Lily J. Huang, Benjamin P. Tu
Publikováno v:
Cell Reports, Vol 12, Iss 3, Pp 371-379 (2015)
Nitrogen permease regulator-like 2 (NPRL2) is a component of a conserved complex that inhibits mTORC1 (mammalian Target Of Rapamycin Complex 1) in response to amino acid insufficiency. Here, we show that NPRL2 is required for mouse viability and that
Externí odkaz:
https://doaj.org/article/e6a38e82828d4c96b42c9a03c9f13bc8
Autor:
Charles E. Chalfant, Sungjune Kim, Raghavendra Pillappa, Cora Uram-Tuculescu, Min-Hsuan Wang, Gamze B. Bulut, Xue Wang, Ngoc T. Vu, Minjung Kim
Supplementary Figure from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4881a2650a281c4f1372699e91f43ed2
https://doi.org/10.1158/1541-7786.22527350.v1
https://doi.org/10.1158/1541-7786.22527350.v1
Autor:
Charles E. Chalfant, Sungjune Kim, Raghavendra Pillappa, Cora Uram-Tuculescu, Min-Hsuan Wang, Gamze B. Bulut, Xue Wang, Ngoc T. Vu, Minjung Kim
Caspase 9 undergoes alternative splicing to produce two opposing isoforms: proapoptotic Caspase 9a and pro-survival Caspase 9b (C9b). Previously, our laboratory reported that C9b is expressed in majority of non–small cell lung cancer tumors and dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc653d9d09485357a5cfefd407e44351
https://doi.org/10.1158/1541-7786.c.6545402.v1
https://doi.org/10.1158/1541-7786.c.6545402.v1
Autor:
Charles E. Chalfant, Amy C. Ladd, Gamze B. Bulut, Michael D. Shultz, Margaret A. Park, Ngoc T. Vu
Methods used for Supplemental Data only: WST-1 cell proliferation assay, Ki-67 mmunohistochemical analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8125c3c70157b30e6963575485e9466b
https://doi.org/10.1158/0008-5472.22408446
https://doi.org/10.1158/0008-5472.22408446
Autor:
Charles E. Chalfant, Amy C. Ladd, Gamze B. Bulut, Michael D. Shultz, Margaret A. Park, Ngoc T. Vu
Supplemental Figure 1: Larger legend table for symbols in fig 1A. Supplemental Figure 2: The expression of BIRC5, CDKN1A, CXCL1 and IER3 correlates with expression of C9b, but not C9a, in human NSCLC tissues. Supplemental Figure 3: Down-regulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d97f19a24807c63fe903c538c9bbdd
https://doi.org/10.1158/0008-5472.22408449
https://doi.org/10.1158/0008-5472.22408449
Autor:
Charles E. Chalfant, Amy C. Ladd, Gamze B. Bulut, Michael D. Shultz, Margaret A. Park, Ngoc T. Vu
Alternate RNA processing of caspase-9 generates the splice variants caspase 9a (C9a) and caspase 9b (C9b). C9b lacks a domain present in C9a, revealing a tumorigenic function that drives the phenotype of non–small cell lung cancer (NSCLC) cells. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f32dd64b0d0a2bcb04bee364bc855f5
https://doi.org/10.1158/0008-5472.c.6507537
https://doi.org/10.1158/0008-5472.c.6507537
Autor:
Charles E. Chalfant, Amy C. Ladd, Gamze B. Bulut, Michael D. Shultz, Margaret A. Park, Ngoc T. Vu
Supplemental Figure Legends for Supplemental Figures 1 through 12.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c9be0d00facafe1ea9f8824fab0e10
https://doi.org/10.1158/0008-5472.22408452.v1
https://doi.org/10.1158/0008-5472.22408452.v1
Autor:
Junchul Shin, Svyatoslav Tkachenko, Malay Chaklader, Connor Pletz, Kanwardeep Singh, Gamze B Bulut, Young min Han, Kelly Mitchell, Richard A Baylis, Andrey A Kuzmin, Bo Hu, Justin D Lathia, Olga Stenina-Adognravi, Eugene Podrez, Tatiana V Byzova, Gary K Owens, Olga A Cherepanova
Publikováno v:
Cardiovasc Res
Aims Until recently, the pluripotency factor Octamer (ATGCAAAT)-binding transcriptional factor 4 (OCT4) was believed to be dispensable in adult somatic cells. However, our recent studies provided clear evidence that OCT4 has a critical atheroprotecti