Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Gamze, Ates"'
Autor:
Rong Fan, Hatice Satilmis, Niels Vandewalle, Emma Verheye, Elke De Bruyne, Eline Menu, Nathan De Beule, Ann De Becker, Gamze Ates, Ann Massie, Tessa Kerre, Marie Törngren, Helena Eriksson, Karin Vanderkerken, Karine Breckpot, Ken Maes, Kim De Veirman
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Acute Myeloid Leukemia (AML) is a heterogeneous disease with limited treatment options and a high demand for novel targeted therapies. Since myeloid-related protein S100A9 is abundantly expressed in AML, we aimed to unravel the therapeutic i
Externí odkaz:
https://doaj.org/article/e3d2c809e45a47e385516477b86ed8c1
Autor:
Zhaolong Pan, Jan-Lars Van den Bossche, Eva Rodriguez-Aznar, Pauline Janssen, Olaya Lara, Gamze Ates, Ann Massie, Diedert Luc De Paep, Isabelle Houbracken, Marco Mambretti, Ilse Rooman
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-10 (2023)
Abstract Acinar cell dedifferentiation is one of the most notable features of acute and chronic pancreatitis. It can also be the initial step that facilitates pancreatic cancer development. In the present study, we further decipher the precise mechan
Externí odkaz:
https://doaj.org/article/adf246e9954541b490c2843a354e56e2
Autor:
Inês Belo do Nascimento, Gamze Ates, Nathalie Desmet, Pauline Beckers, Ann Massie, Emmanuel Hermans
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1183 (2023)
Alterations in the activity of the regulator of cell metabolism AMP-activated protein kinase (AMPK) have been reported in motor neurons from patients and animal models of amyotrophic lateral sclerosis (ALS). Considering the key role played by astrocy
Externí odkaz:
https://doaj.org/article/534ea97792394728a8336b60f634aab9
Targeting of intracellular Ca2+ stores as a therapeutic strategy against age-related neurotoxicities
Autor:
Joshua Goldberg, Antonio Currais, Gamze Ates, Ling Huang, Maxim Shokhirev, Pamela Maher, David Schubert
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-9 (2020)
Abstract Calcium dysregulation often underlies pathologies associated with aging and age-associated neurodegenerative diseases. Cells express a unique pattern of Ca2+ channels and pumps geared to fulfill specific physiological requirements and there
Externí odkaz:
https://doaj.org/article/aab8f71534334401ab0fe2d1f969c108
Autor:
Arne Van der Vreken, Inge Oudaert, Gamze Ates, Sylvia Faict, Philip Vlummens, Hatice Satilmis, Rong Fan, Anke Maes, Ann Massie, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Eline Menu
Publikováno v:
The Journal of Pathology. 260:112-123
Multiple myeloma (MM) remains an incurable haematological malignancy despite substantial advances in therapy. Hypoxic bone marrow induces metabolic rewiring in MM cells contributing to survival and drug resistance. Therefore, targeting metabolic path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77409056e344c1433d1482f6efa3d0c
https://doi.org/10.1002/path.6066
https://doi.org/10.1002/path.6066
Autor:
Inês Belo do Nascimento, Marie Verfaillie, Gamze Ates, Pauline Beckers, Virginie Joris, Nathalie Desmet, Ann Massie, Emmanuel Hermans
Publikováno v:
Cells, Vol 11, Iss 11, p 1800 (2022)
Energy homeostasis in the central nervous system largely depends on astrocytes, which provide metabolic support and protection to neurons. Astrocytes also ensure the clearance of extracellular glutamate through high-affinity transporters, which indir
Externí odkaz:
https://doaj.org/article/7d291e408996464abd1c4c3feac5a823
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101648- (2020)
The oxidative degradation of lipids has been shown to be implicated in the progression of several neurodegenerative diseases and modulating lipid peroxidation may be efficacious for treating Alzheimer’s disease (AD). This hypothesis is strengthened
Externí odkaz:
https://doaj.org/article/57530a78ae8a45548754a7d271ce1174
Autor:
Hatice Satilmis, Emma Verheye, Philip Vlummens, Inge Oudaert, Niels Vandewalle, Rong Fan, Jennifer M Knight, Nathan De Beule, Gamze Ates, Ann Massie, Jerome Moreaux, Anke Maes, Elke De Bruyne, Karin Vanderkerken, Eline Menu, Erica K Sloan, Kim De Veirman
Publikováno v:
Vrije Universiteit Brussel
While multi-drug combinations and continuous treatment have become standard for multiple myeloma, the disease remains incurable. Repurposing drugs that are currently used for other indications could provide a novel approach to improve the therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5d13a82779ca4fd9bac34ec18b42d1
https://doi.org/10.1002/path.6020
https://doi.org/10.1002/path.6020
Autor:
Antonio Currais, Ling Huang, Joshua Goldberg, Michael Petrascheck, Gamze Ates, António Pinto-Duarte, Maxim N Shokhirev, David Schubert, Pamela Maher
Publikováno v:
eLife, Vol 8 (2019)
Because old age is the greatest risk factor for dementia, a successful therapy will require an understanding of the physiological changes that occur in the brain with aging. Here, two structurally distinct Alzheimer's disease (AD) drug candidates, CM
Externí odkaz:
https://doaj.org/article/762cb486b87d4e0ca58ae16661257ea1
Autor:
Lise Verbruggen, Gamze Ates, Olaya Lara, Jolien De Munck, Agnès Villers, Laura De Pauw, Sigrid Ottestad-Hansen, Sho Kobayashi, Pauline Beckers, Pauline Janssen, Hideyo Sato, Yun Zhou, Emmanuel Hermans, Rose Njemini, Lutgarde Arckens, Niels C. Danbolt, Dimitri De Bundel, Joeri L. Aerts, Kurt Barbé, Benoit Guillaume, Laurence Ris, Eduard Bentea, Ann Massie
Publikováno v:
Molecular Psychiatry, (2022)
The cystine/glutamate antiporter system xc− has been identified as the major source of extracellular glutamate in several brain regions as well as a modulator of neuroinflammation, and genetic deletion of its specific subunit xCT (xCT−/−) is pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb057e10d0c8d517f124d8596bbdc30e
https://doi.org/10.1038/s41380-022-01470-5
https://doi.org/10.1038/s41380-022-01470-5