Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.

Autor: Duperron MG; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.; Department of Neurology, Institute of Neurodegenerative Diseases, Bordeaux University Hospital, Bordeaux, France., Knol MJ; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Le Grand Q; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France., Evans TE; Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Mishra A; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France., Tsuchida A; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.; Groupe d'Imagerie Neurofonctionelle - Institut des maladies neurodégénératives (GIN-IMN), UMR 5293, University of Bordeaux, CNRS, CEA, Bordeaux, France., Roshchupkin G; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Konuma T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Trégouët DA; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France., Romero JR; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; The Framingham Heart Study, Framingham, MA, USA., Frenzel S; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Luciano M; School of Psychology, University of Edinburgh, Edinburgh, UK., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Bourgey M; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montreal, Quebec, Canada.; Canadian Centre for Computational Genomics, McGill University, Montreal, Quebec, Canada., Dueker ND; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Delgado P; Institut de Recerca Vall d'hebron, Neurovascular Research Lab, Universitat Autònoma de Barcelona, Barcelona, Spain.; Hospital Universitari Vall d'Hebron, Neurology Department, Universitat Autònoma de Barcelona, Barcelona, Spain., Hilal S; Memory Aging and Cognition Center, National University Health System, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Tankard RM; Department of Mathematics and Statistics, Curtin University, Perth, Western Australia, Australia., Dubost F; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Shin J; The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.; Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada., Saba Y; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.; Institute for Molecular Biology & Biochemistry, Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Graz, Austria., Armstrong NJ; Department of Mathematics and Statistics, Curtin University, Perth, Western Australia, Australia., Bordes C; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France., Bastin ME; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Beiser A; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; The Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Brodaty H; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.; Dementia Collaborative Research Centre Assessment and Better Care, UNSW, Sydney, New South Wales, Australia., Bülow R; Institute for Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Carrera C; Stroke Pharmacogenomics and Genetics Group, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain., Chen C; Memory Aging and Cognition Center, National University Health System, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Center for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore., Deary IJ; School of Psychology, University of Edinburgh, Edinburgh, UK., Gampawar PG; Institute for Molecular Biology & Biochemistry, Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Graz, Austria., Himali JJ; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; The Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.; Department of Population Health Sciences, UT Health San Antonio, San Antonio, TX, USA., Jiang J; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Li S; The Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Macalli M; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France., Marquis P; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montreal, Quebec, Canada.; Canadian Centre for Computational Genomics, McGill University, Montreal, Quebec, Canada., Morris Z; Neuroimaging, Department of Clinical Neurosciences, Royal Infirmary of Edinburgh, Edinburgh, UK., Muñoz Maniega S; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute Centre at the University of Edinburgh, Edinburgh, UK., Miyamoto S; Kyoto University Hospital, Kyoto, Japan., Okawa M; Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan., Paradise M; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia., Parva P; The Framingham Heart Study, Framingham, MA, USA.; Radiology Department, Boston University School of Medicine, Boston, MA, USA.; Department of Radiology, Harvard Medical School, Boston, MA, USA., Rundek T; Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.; Evelyn F. McKnight Brain Institute, Department of Neurology, University of Miami, Miami, FL, USA., Sargurupremraj M; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France., Schilling S; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France., Setoh K; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan., Soukarieh O; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thalamuthu A; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia., Trollor JN; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.; Department of Developmental Disability Neuropsychiatry, UNSW, Sydney, New South Wales, Australia., Valdés Hernández MC; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Row Fogo Centre for Research into Ageing and the Brain, University of Edinburgh, Edinburgh, UK., Vernooij MW; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Wittfeld K; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Tsinghua Medicine, Tsinghua University, Beijing, China., Wright MJ; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.; Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia., Zhang J; Department of Neurology, Peking Union Medical College Hospital, Beijing, China., Zhao W; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; The Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore., Zhu YC; Department of Neurology, Peking Union Medical College Hospital, Beijing, China., Schmidt H; Institute for Molecular Biology & Biochemistry, Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Graz, Austria., Sachdev PS; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.; Neuropsychiatric Institute, the Prince of Wales Hospital, Sydney, New South Wales, Australia., Wen W; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia., Yoshida K; Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan., Joutel A; Institut de Psychiatrie et Neurosciences de Paris, Université Paris Cité, Inserm, France., Satizabal CL; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; The Framingham Heart Study, Framingham, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.; Department of Population Health Sciences, UT Health San Antonio, San Antonio, TX, USA., Sacco RL; Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.; Evelyn F. McKnight Brain Institute, Department of Neurology, University of Miami, Miami, FL, USA.; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Department of Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.; Department of Neurosurgery, Miller School of Medicine, University of Miami, Miami, FL, USA., Bourque G; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montreal, Quebec, Canada.; Canadian Centre for Computational Genomics, McGill University, Montreal, Quebec, Canada., Lathrop M; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montreal, Quebec, Canada., Paus T; University of Montreal, Faculty of Medicine, Departments of Psychiatry and Neuroscience, Montreal, Quebec, Canada.; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.; Centre Hospitalier Universitaire Sainte Justine, Montreal, Quebec, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Fernandez-Cadenas I; Stroke Pharmacogenomics and Genetics Group, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.; Stroke Pharmacogenomics and Genetics Group, Fundació per la Docència i la Recerca Mutua Terrassa, Terrassa, Spain., Yang Q; The Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Mazoyer B; Groupe d'Imagerie Neurofonctionelle - Institut des maladies neurodégénératives (GIN-IMN), UMR 5293, University of Bordeaux, CNRS, CEA, Bordeaux, France.; Bordeaux University Hospital, Bordeaux, France., Boutinaud P; Fealinx, Lyon, France., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.; Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany., Mather KA; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, University of New South Wales, Sydney, New South Wales, Australia.; Neuroscience Research Australia, Sydney, New South Wales, Australia., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria., Joliot M; Groupe d'Imagerie Neurofonctionelle - Institut des maladies neurodégénératives (GIN-IMN), UMR 5293, University of Bordeaux, CNRS, CEA, Bordeaux, France., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Tzourio C; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France.; Department of Medical Informatics, Bordeaux University Hospital, Bordeaux, France., Wardlaw JM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute Centre at the University of Edinburgh, Edinburgh, UK.; Row Fogo Centre for Research into Ageing and the Brain, University of Edinburgh, Edinburgh, UK., Seshadri S; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; The Framingham Heart Study, Framingham, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.; Department of Population Health Sciences, UT Health San Antonio, San Antonio, TX, USA., Adams HHH; Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, the Netherlands. h.adams@erasmusmc.nl.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands. h.adams@erasmusmc.nl.; Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile. h.adams@erasmusmc.nl., Debette S; Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France. stephanie.debette@u-bordeaux.fr.; Department of Neurology, Institute of Neurodegenerative Diseases, Bordeaux University Hospital, Bordeaux, France. stephanie.debette@u-bordeaux.fr.

Publikováno v: Nature medicine [Nat Med] 2023 Apr; Vol. 29 (4), pp. 950-962. Date of Electronic Publication: 2023 Apr 17.

Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.

Autor: Armstrong NJ; Mathematics and Statistics, Murdoch University, Perth, Australia (N.J.A.)., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia (K.A.M., P.R.S., A.T.)., Sargurupremraj M; University Bordeaux, Inserm, Bordeaux Population Health Research Center, France (M.S., C.T., S.D.)., Knol MJ; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.)., Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-Universität LMU Munich, Germany (R.M., M.D.)., Satizabal CL; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX (C.L.S., S.S.).; The Framingham Heart Study, MA (C.L.S., A.S.B., J.R.R., S.S.).; Department of Neurology (C.L.S., A.S.B., J.R.R., S.S.), Boston University School of Medicine, MA., Yanek LR; GeneSTAR Research Program (L.R.Y., B.G.K., L.C.B., P.A.N.), Johns Hopkins University School of Medicine, Baltimore, MD., Wen W; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia., Gudnason VG; Icelandic Heart Association, Kopavogur (V.G.G., S.S.).; University of Iceland, Reykjavik, Iceland (V.G.G., A.V.S.)., Dueker ND; Dr. John T. Macdonald Foundation Department of Human Genetics (R.L.S.), University of Miami, FL., Elliott LT; Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada (L.T.E.).; Wellcome Centre for Integrative Neuroimaging (WIN FMRIB) (L.T.E., F.A.-A., L.G., M.J., S.M.S.), University of Oxford, United Kingdom., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria (E.H., R.S.).; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria (E.H.)., Bis J; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA (J.B., B.P., W.L.)., Jahanshad N; Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey (N.J., P.M.T.)., Li S; Department of Biostatistics, Boston University School of Public Health, Boston, MA (S.L., M.A.L., A.S.B., Q.Y.)., Logue MA; Department of Psychiatry and Biomedical Genetics Section (M.A.L.), Boston University School of Medicine, MA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA (S.L., M.A.L., A.S.B., Q.Y.).; National Center for PTSD: Behavioral Science Division, VA Boston Healthcare System, Boston, MA (M.A.L.)., Luciano M; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom (M.L., I.J.D., D.C.M.L., M.E.B., J.M.W.)., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology (M.S.)., Smith AV; University of Iceland, Reykjavik, Iceland (V.G.G., A.V.S.)., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics (S.T.), Leiden University Medical Center, the Netherlands.; Department of Cardiology (S.T.), Leiden University Medical Center, the Netherlands., Vojinovic D; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.)., Xia R; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, TX (R.X., M.F.)., Alfaro-Almagro F; Wellcome Centre for Integrative Neuroimaging (WIN FMRIB) (L.T.E., F.A.-A., L.G., M.J., S.M.S.), University of Oxford, United Kingdom., Ames D; National Ageing Research Institute, Parkville, Victoria, Australia (D.A.).; Academic Unit for Psychiatry of Old Age, University of Melbourne, St George's Hospital, Kew, Australia (D.A.)., Amin N; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.)., Amouyel P; Lille University, Inserm, Institut Pasteur de Lille, RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases and Labex Distalz, France (P.A.).; Lille University, Inserm, CHU Lille, Institut Pasteur de Lille, RID-AGE (P.A.)., Beiser AS; The Framingham Heart Study, MA (C.L.S., A.S.B., J.R.R., S.S.).; Department of Neurology (C.L.S., A.S.B., J.R.R., S.S.), Boston University School of Medicine, MA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA (S.L., M.A.L., A.S.B., Q.Y.)., Brodaty H; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia.; Dementia Centre for Research Collaboration (H.B.), University of New South Wales, Sydney, Australia., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom (M.L., I.J.D., D.C.M.L., M.E.B., J.M.W.)., Fennema-Notestine C; Department of Psychiatry (C.F.-N.), University of California, San Diego, La Jolla, CA.; Center for Behavior Genetics of Aging (C.F.-N.), University of California, San Diego, La Jolla, CA., Gampawar PG; Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Austria (P.G.G., H.S.)., Gottesman R; Department of Neurology, Cerebrovascular and stroke Division (R.G.), Johns Hopkins University School of Medicine, Baltimore, MD., Griffanti L; Wellcome Centre for Integrative Neuroimaging (WIN FMRIB) (L.T.E., F.A.-A., L.G., M.J., S.M.S.), University of Oxford, United Kingdom., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, MN (C.R.J.J.)., Jenkinson M; Wellcome Centre for Integrative Neuroimaging (WIN FMRIB) (L.T.E., F.A.-A., L.G., M.J., S.M.S.), University of Oxford, United Kingdom., Jiang J; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia., Kral BG; GeneSTAR Research Program (L.R.Y., B.G.K., L.C.B., P.A.N.), Johns Hopkins University School of Medicine, Baltimore, MD., Kwok JB; School of Medical Sciences (J.B.K., P.R.S.), University of New South Wales, Sydney, Australia.; Brain and Mind Centre - The University of Sydney, Camperdown, NSW, Australia (J.B.K.)., Lampe L; Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (L.L., V.A.W.)., C M Liewald D; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom (M.L., I.J.D., D.C.M.L., M.E.B., J.M.W.)., Maillard P; Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California-Davis, Davis, CA (P.M.)., Marchini J; Statistical Genetics and Methods at Regeneron Pharmaceuticals, Inc, New York, NY (J.M.)., Bastin ME; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom (M.L., I.J.D., D.C.M.L., M.E.B., J.M.W.).; Centre for Clinical Brain Sciences, Edinburgh Imaging, Centre for Cognitive Ageing, University of Edinburgh, United Kingdom (M.E.B., J.M.W.)., Mazoyer B; Institut des Maladies Neurodégénératives, University of Bordeaux, France (B.M.)., Pirpamer L; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria (L.P.)., Rafael Romero J; The Framingham Heart Study, MA (C.L.S., A.S.B., J.R.R., S.S.).; Department of Neurology (C.L.S., A.S.B., J.R.R., S.S.), Boston University School of Medicine, MA., Roshchupkin GV; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.).; Department of Radiology and Nuclear Medicine (G.V.R., M.W.V., H.H.H.A.)., Schofield PR; School of Medical Sciences (J.B.K., P.R.S.), University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia (K.A.M., P.R.S., A.T.)., Schroeter ML; LIFE Research Center for Civilization Disease, Leipzig, Germany (M.S.).; Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (M.L.S., A.V.).; Day Clinic for Cognitive Neurology, University Hospital Leipzig, Germany (M.L.S., A.V.)., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom (D.J.S.)., Thalamuthu A; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia (K.A.M., P.R.S., A.T.)., Trollor J; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia.; Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), University of New South Wales, Sydney, Australia., Tzourio C; University Bordeaux, Inserm, Bordeaux Population Health Research Center, France (M.S., C.T., S.D.).; CHU de Bordeaux, Public Health Department, Medical information Department, Bordeaux, France (C.T.)., van der Grond J; Department of Radiology (J.v.d.G.), Leiden University Medical Center, the Netherlands., Vernooij MW; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.).; Department of Radiology and Nuclear Medicine (G.V.R., M.W.V., H.H.H.A.)., Witte VA; Collaborative Research Center 1052 Obesity Mechanisms, Faculty of Medicine, University of Leipzig, Germany (V.A.W).; Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (L.L., V.A.W.)., Wright MJ; Queensland Brain Institute (M.J.W.), The University of Queensland, St Lucia, QLD, Australia.; Centre for Advanced Imaging (M.J.W.), The University of Queensland, St Lucia, QLD, Australia., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA (S.L., M.A.L., A.S.B., Q.Y.)., Morris Z; Neuroradiology Department, Department of Clinical Neurosciences, Western General Hospital, Edinburgh, United Kingdom (Z.M.)., Siggurdsson S; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX (C.L.S., S.S.).; The Framingham Heart Study, MA (C.L.S., A.S.B., J.R.R., S.S.).; Department of Neurology (C.L.S., A.S.B., J.R.R., S.S.), Boston University School of Medicine, MA., Psaty B; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA (J.B., B.P., W.L.)., Villringer A; Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (M.L.S., A.V.).; Day Clinic for Cognitive Neurology, University Hospital Leipzig, Germany (M.L.S., A.V.)., Schmidt H; Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Medical University of Graz, Austria (P.G.G., H.S.)., Haberg AK; Department of Neuromedicine and Movement Science (A.K.H.), Norwegian University of Science and Technology, Trondheim, Norway.; Department of Radiology and Nuclear Medicine (A.K.H.), Norwegian University of Science and Technology, Trondheim, Norway., van Duijn CM; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.).; Nuffield Department of Population Health (C.M.v.D.), University of Oxford, United Kingdom., Jukema JW; Department of Cardiology (J.W.J.), Leiden University Medical Center, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, the Netherlands (J.W.J.)., Dichgans M; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-Universität LMU Munich, Germany (R.M., M.D.).; German Center for Neurodegenerative Diseases, Munich, Germany (M.D.).; Munich Cluster for Systems Neurology (SyNergy), Germany (M.D.)., Sacco RL; Department of Public Health Sciences, Miller School of Medicine (R.L.S.), University of Miami, FL.; Department of Neurology, Miller School of Medicine (R.L.S.), University of Miami, FL.; Evelyn F. McKnight Brain Institute, Department of Neurology (R.L.S.), University of Miami, FL., Wright CB; National Institute of Neurological Disorders and Stroke (C.B.W.), National Institutes of Health, Bethesda, MD., Kremen WS; Center for Behavior Genetics of Aging (W.S.K.), University of California, San Diego, La Jolla, CA.; Department of Psychiatry (W.S.K.), University of California, San Diego, La Jolla, CA., Becker LC; GeneSTAR Research Program (L.R.Y., B.G.K., L.C.B., P.A.N.), Johns Hopkins University School of Medicine, Baltimore, MD., Thompson PM; Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey (N.J., P.M.T.)., Mosley TH; Department of Geriatric Medicine, Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson (T.H.M.)., Wardlaw JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, United Kingdom (M.L., I.J.D., D.C.M.L., M.E.B., J.M.W.).; Centre for Clinical Brain Sciences, Edinburgh Imaging, Centre for Cognitive Ageing, University of Edinburgh, United Kingdom (M.E.B., J.M.W.)., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.)., Adams HHH; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (M.J.K., D.V., N.A., G.V.R., M.W.V., C.M.v.D., M.A.I., H.H.H.A.).; Department of Radiology and Nuclear Medicine (G.V.R., M.W.V., H.H.H.A.).; Department of Clinical Genetics, Erasmus MC, Rotterdam, the Netherlands (H.H.H.A.)., Seshadri S; Icelandic Heart Association, Kopavogur (V.G.G., S.S.)., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry (K.A.M., W.W., H.B., J.J., A.T., J.T., P.S.S.), University of New South Wales, Sydney, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia (P.S.S.)., Smith SM; Wellcome Centre for Integrative Neuroimaging (WIN FMRIB) (L.T.E., F.A.-A., L.G., M.J., S.M.S.), University of Oxford, United Kingdom., Launer L; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program (L.L.), National Institutes of Health, Bethesda, MD., Longstreth W; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA (J.B., B.P., W.L.)., DeCarli C; Alzheimer's Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience University of California at Davis (C.D.)., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria (E.H., R.S.)., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, TX (R.X., M.F.).; Human Genetics Center, School of Public Health UT, Houston, TX (M.F.)., Debette S; University Bordeaux, Inserm, Bordeaux Population Health Research Center, France (M.S., C.T., S.D.).; Department of Neurology, CHU de Bordeaux (University Hospital), Bordeaux, France (S.D.)., Nyquist PA; GeneSTAR Research Program (L.R.Y., B.G.K., L.C.B., P.A.N.), Johns Hopkins University School of Medicine, Baltimore, MD.; Departments of Neurology, Critical Care Medicine, Neurosurgery (P.A.N.), Johns Hopkins University School of Medicine, Baltimore, MD.; Critical Care Medicine Department (P.A.N.), National Institutes of Health, Bethesda, MD.

Publikováno v: Stroke [Stroke] 2020 Jul; Vol. 51 (7), pp. 2111-2121. Date of Electronic Publication: 2020 Jun 10.