Zobrazeno 1 - 10
of 348
pro vyhledávání: '"Gamma-secretase complex"'
Publikováno v:
Revista da Sociedade Portuguesa de Dermatologia e Venereologia, Vol 80, Iss 4 (2022)
Hidradenitis suppurative (HS) is a multifactorial, recurrent, chronic inflammatory disease with a significant impact on patient’s quality of life. The etiopathogenesis of this complex condition is not fully understood. In this systematic review, we
Externí odkaz:
https://doaj.org/article/513e372e118440f18b9e6dd4b79aa1fd
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Hidradenitis suppurativa (HS) is a disease of the pilosebaceous unit characterized by recurrent nodules, abscesses and draining tunnels with a predilection to intertriginous skin. The pathophysiology of HS is complex. However, it is known that inflam
Externí odkaz:
https://doaj.org/article/73c0eeabd2ca4fa18ba0917cf6219b57
Autor:
Gautham Vellaichamy, Anya T. Amin, Peter Dimitrion, Zaakir Hamzavi, Li Zhou, Indra Adrianto, Qing-Sheng Mi
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Hidradenitis suppurativa (HS) is a multifactorial chronic skin disease characterized by inflammation around the hair follicles commonly affecting intertriginous areas. The underlying pathogenesis of HS and its molecular mechanisms are largely underst
Externí odkaz:
https://doaj.org/article/bc39af0134a94d3a8daec8eee79db80e
Autor:
Inge Govaerts, Cristina Prieto, Charlien Vandersmissen, Olga Gielen, Kris Jacobs, Sarah Provost, David Nittner, Johan Maertens, Nancy Boeckx, Kim De Keersmaecker, Heidi Segers, Jan Cools
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background T cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype that comprises 10–15% of childhood and 20–25% of adult ALL cases. Over 70% of T-ALL patients harbor activating mutations in the NOTCH1 signaling pathway and ar
Externí odkaz:
https://doaj.org/article/bb40113fbbf041209361b8411e7b5c92
Autor:
John W. Frew, Kristina Navrazhina
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
Background: Familial Hidradenitis Suppurativa and Familial Alzheimer's Disease are both associated with Gamma-Secretase Complex mutations; however, the two diseases are not epidemiologically associated. Understanding the molecular differences between
Externí odkaz:
https://doaj.org/article/cfeeef77c5ed4319b082c8b1fc2be3b2
Autor:
Seçil Vural, W. Chen, Housien Hariry, Mark Baumgartner, Gerd Plewig, Gertrud Eckstein, Thomas Ruzicka, Bodo C. Melnik, Matthias Wagner, Peter Lichtner, Kathrin A. Giehl
Publikováno v:
Journal of the European Academy of Dermatology and Venereology. 35:1386-1392
Background Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting apocrine gland-bearing skin in the axilla, groin and under the breasts. Mutations of the gamma secretase gene complex, which is essential in the activation of Notch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b983695ee206b09af1a252718085d64
https://doi.org/10.1111/jdv.17163
https://doi.org/10.1111/jdv.17163
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Huijie Bian, Yu-Le Yong, Ding Wei, Jiao Wu, Ren-Yu Zhang, Ze-Kun Liu, Zhi-Nan Chen, Zhi-Yun Zhang, Can Li, Yu-Kui Shang
Publikováno v:
The Journal of Pathology. 249:255-267
The γ-secretase complex is a presenilin-dependent aspartyl protease involved in the intramembranous cleavage of various type I transmembrane proteins. As a type I transmembrane protein, CD147 is highly expressed in hepatoma cells and promotes cell p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e93d4248458da87cc39241cd991770f
https://doi.org/10.1002/path.5316
https://doi.org/10.1002/path.5316
Autor:
Olga Gielen, Inge Govaerts, Jan Cools, Kris Jacobs, Nancy Boeckx, Sarah Provost, David Nittner, Kim De Keersmaecker, Cristina Prieto, Johan Maertens, Heidi Segers, Charlien Vandersmissen
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-14 (2021)
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-14 (2021)
Background T cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype that comprises 10–15% of childhood and 20–25% of adult ALL cases. Over 70% of T-ALL patients harbor activating mutations in the NOTCH1 signaling pathway and are predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3ef8c9a58c825441cc6b1e1de69815
http://europepmc.org/articles/PMC8223323
http://europepmc.org/articles/PMC8223323