Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Gamma Chi"'
Autor:
Huanyu Z. Li, Ashley C. W. Pike, Irina Lotsaris, Gamma Chi, Jesper S. Hansen, Sarah C. Lee, Karin E. J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Robert J. Vandenberg, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. T
Externí odkaz:
https://doaj.org/article/32dcb0d22d77485888ff653efcd48c4e
Autor:
Qiansheng Liang, Gamma Chi, Leonardo Cirqueira, Lianteng Zhi, Agostino Marasco, Nadia Pilati, Martin J. Gunthorpe, Giuseppe Alvaro, Charles H. Large, David B. Sauer, Werner Treptow, Manuel Covarrubias
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Small-molecule modulators of diverse voltage-gated K+ (Kv) channels may help treat a wide range of neurological disorders. However, developing effective modulators requires understanding of their mechanism of action. We apply an orthogonal a
Externí odkaz:
https://doaj.org/article/cd3c8dd7577c4ee08657c1ab9f7f472d
Autor:
Gamma Chi, Qiansheng Liang, Akshay Sridhar, John B. Cowgill, Kasim Sader, Mazdak Radjainia, Pu Qian, Pablo Castro-Hartmann, Shayla Venkaya, Nanki Kaur Singh, Gavin McKinley, Alejandra Fernandez-Cid, Shubhashish M. M. Mukhopadhyay, Nicola A. Burgess-Brown, Lucie Delemotte, Manuel Covarrubias, Katharina L. Dürr
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Chi et al. report cryo-EM structures of the human Kv3.1a channel, revealing a unique arrangement of the cytoplasmic T1 domain, which allows the interactions with the C-terminal axonal targeting motif and key components of the gating machinery.
Externí odkaz:
https://doaj.org/article/3b1f137234894981ba29f62e3c7d792a
Autor:
Huanyu Z. Li, Ashley C.W. Pike, Gamma Chi, Jesper S. Hansen, Sarah G. Lee, Karin E.J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. To underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd0b3c1551d3725c4f410b48f6a6e46
https://doi.org/10.1101/2023.05.17.541173
https://doi.org/10.1101/2023.05.17.541173
Autor:
John J. Kelly, Dale Tranter, Els Pardon, Gamma Chi, Holger Kramer, Lotta Happonen, Kelly M. Knee, Jay M. Janz, Jan Steyaert, Christine Bulawa, Ville O. Paavilainen, Juha T. Huiskonen, Wyatt W. Yue
Publikováno v:
Nature Structural & Molecular Biology. 29:420-429
The integrity of a cell's proteome depends on correct folding of polypeptides by chaperonins. The chaperonin TCP-1 ring complex (TRiC) acts as obligate folder for >10% of cytosolic proteins, including he cytoskeletal proteins actin and tubulin. Altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c6ef58fbb341764a444fd4085970ed
https://doi.org/10.1038/s41594-022-00755-1
https://doi.org/10.1038/s41594-022-00755-1
Autor:
Shayla Venkaya, Gamma Chi, N.A. Burgess-Brown, Pu Qian, Alejandra Fernández-Cid, Katharina L. Duerr, Kasim Sader, Lucie Delemotte, Manuel Covarrubias, Mazdak Radjainia, Gavin McKinley, Shubhashish M.M. Mukhopadhyay, Pablo Castro-Hartmann, Nanki Kaur Singh, Qiansheng Liang, Akshay Sridhar
Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes severe epileptic disorders, yet the structural determinants for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18daad6687d0b1bf7eba32f0dc453a1a
https://doi.org/10.21203/rs.3.rs-828003/v1
https://doi.org/10.21203/rs.3.rs-828003/v1
Autor:
Gamma Chi, Qiansheng Liang, Akshay Sridhar, John B. Cowgill, Kasim Sader, Mazdak Radjainia, Pu Qian, Pablo Castro-Hartmann, Shayla Venkaya, Nanki Kaur Singh, Gavin McKinley, Alejandra Fernandez-Cid, Shubhashish M. M. Mukhopadhyay, Nicola A. Burgess-Brown, Lucie Delemotte, Manuel Covarrubias, Katharina L. Dürr
Publikováno v:
Nature Communications
Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes severe epileptic disorders, yet the structural determinants for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f12c53a3703e4b32471ede4830f9bff
https://pubmed.ncbi.nlm.nih.gov/35840565
https://pubmed.ncbi.nlm.nih.gov/35840565
Autor:
Rebecca Ebenhoch, S.M.M. Mukhopadhyay, Samira Slimani, Henry Man, Gavin McKinley, Gabriella Reggiano, Patrizia Abrusci, Gamma Chi, Nicola A. Burgess-Brown, Kiran Bountra, Idlir Liko, Alexandre P. Garneau, Ben Tehan, Frank DiMaio, Katharina L. Dürr, Ali Jazayeri, Carol V. Robinson, Alejandra Fernández-Cid, Laurence E. Tremblay, Tina Bohstedt, Christophe P Moreau, Julie L. Lavoie, Xingyu Qiu, Haiping Tang, Dong Wang, Fernando G. Almeida, Paul Isenring
Publikováno v:
The EMBO Journal
'EMBO Journal ', vol: 40, pages: e107294-1-e107294-20 (2021)
EMBO J
'EMBO Journal ', vol: 40, pages: e107294-1-e107294-20 (2021)
EMBO J
Potassium-coupled chloride transporters (KCCs) play crucial roles in regulating cell volume and intracellular chloride concentration. They are characteristically inhibited under isotonic conditions via phospho-regulatory sites located within the cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3901c064e34846dc7faf110fe142fdee
https://doi.org/10.15252/embj.2020107294
https://doi.org/10.15252/embj.2020107294
Autor:
John J, Kelly, Dale, Tranter, Els, Pardon, Gamma, Chi, Holger, Kramer, Lotta, Happonen, Kelly M, Knee, Jay M, Janz, Jan, Steyaert, Christine, Bulawa, Ville O, Paavilainen, Juha T, Huiskonen, Wyatt W, Yue
Publikováno v:
Nature structuralmolecular biology. 29(5)
The integrity of a cell's proteome depends on correct folding of polypeptides by chaperonins. The chaperonin TCP-1 ring complex (TRiC) acts as obligate folder for10% of cytosolic proteins, including he cytoskeletal proteins actin and tubulin. Althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3f1a29810face2c95b478b4c1937b85
https://pubmed.ncbi.nlm.nih.gov/35449234
https://pubmed.ncbi.nlm.nih.gov/35449234
Autor:
Henry Man, Nicola A. Burgess-Brown, Shubhashish M.M. Mukhopadhyay, Katherine J. Ellis, Alejandra Fernández-Cid, Pravin Mahajan, Katharina L. Dürr, Gamma Chi
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608913
This chapter describes the step-by-step methods employed by the Structural Genomics Consortium (SGC) for screening and producing proteins in the BacMam system. This eukaryotic expression system was selected and a screening process established in 2016
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ccb4a2abb72410cca76ff3ab046dfd4
https://doi.org/10.1007/978-1-0716-0892-0_6
https://doi.org/10.1007/978-1-0716-0892-0_6