Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Gamini, Chandrasena"'
Autor:
Roland Staal, Tanzilya Khayrullina, Rie Christensen, Sara Hestehave, Hua Zhou, Manuel Cajina, Megan E. Nattini, Adarsh Gandhi, Shaun M. Fallon, Megan Schmidt, Stevin H. Zorn, Robbin M. Brodbeck, Gamini Chandrasena, Märta Segerdahl, Nathalie Breysse, Allen T. Hopper, Thomas Möller, Gordon Munro
Publikováno v:
European Journal of Pain. 26:1304-1321
P2X7 receptor antagonists have potential for treating various central nervous system (CNS) diseases, including neuropathic pain, although none have been approved for clinical use. Reasons may include insufficient understanding of P2X7 receptor signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328d97f05ac747420878a1c2b99ac554
https://doi.org/10.1002/ejp.1951
https://doi.org/10.1002/ejp.1951
Autor:
Noel J. Boyle, Jessie Weiss, Gamini Chandrasena, Lingyun Wu, Andrew D. White, Dario Doller, Michael Sabio, John M. Peterson, Eman Edelmenky, Rajinder Bhardwaj, Xinyan Huang, Chien An Chen, Jiang Yu, Burns James Ford, Bin Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1458-1461
The NPY5 receptor binding and pharmacokinetic properties of a novel series of cis-1-oxo-heterocyclyl-4-amido-cyclohexane derivatives are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f150a8e5e1c03e2d0966895d4d5e9256
https://doi.org/10.1016/j.bmcl.2014.02.023
https://doi.org/10.1016/j.bmcl.2014.02.023
Autor:
Dario Doller, Dekun Song, Gamini Chandrasena, Xinyan Huang, Francine Acher, Christoffer Bundgaard, Gennady N. Smagin, Megan Nattini, Dorthe Bach Toft, Erling B. Jørgensen, Manuel Cajina
Publikováno v:
ACS Medicinal Chemistry Letters. 5:119-123
LSP1-2111 is a group III metabotropic glutamate receptor agonist with preference toward the mGlu4 receptor subtype. This compound has been extensively used as a tool to explore the pharmacology of mGlu4 receptor activation in preclinical animal behav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b148f0f0b49bbce88f7b50895059bd97
https://doi.org/10.1021/ml400338f
https://doi.org/10.1021/ml400338f
Autor:
Dario Doller, Guiying Li, Hermogenes N. Jimenez, Robbin Brodbeck, Michelle A. Uberti, Daniel G. Smith, Hao Zhou, Jens Christian Madsen, Henrik Pedersen, Michel Grenon, Gamini Chandrasena, Sidney W. Topiol
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1398-1406
A novel series of trans-1,3-cyclohexyl diamides was discovered and characterized as mGluR5 negative allosteric modulators (NAMs) lacking an alkyne moiety. Conformational constraint of one of the amide bonds in the diamide template led to a spirooxazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ab971983d6dcff5223bdaed66c13e9
https://doi.org/10.1016/j.bmcl.2012.12.078
https://doi.org/10.1016/j.bmcl.2012.12.078
Autor:
Dorrit Østergaard Nilausen, Christoffer Bundgaard, Anne-Marie Jacobsen, Klaus Gjervig Jensen, Gamini Chandrasena, Zia Irene Thale, Martin Jørgensen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 45(1)
Inclusion of a microdose of 14C-labeled drug in the first-in-man study of new investigational drugs and subsequent analysis by accelerator mass spectrometry has become an integrated part of drug development at Lundbeck. It has been found to be highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7949df03c322c187da448b804b6e1a3e
https://pubmed.ncbi.nlm.nih.gov/27737930
https://pubmed.ncbi.nlm.nih.gov/27737930
Autor:
Roland G W, Staal, Tanzilya, Khayrullina, Hong, Zhang, Scott, Davis, Shaun M, Fallon, Manuel, Cajina, Megan E, Nattini, Andrew, Hu, Hua, Zhou, Suresh Babu, Poda, Stevin, Zorn, Gamini, Chandrasena, Elena, Dale, Brian, Cambpell, Lars Christian, Biilmann Rønn, Gordon, Munro, Thomas, Mӧller
Publikováno v:
European journal of pharmacology. 795
Neuropathic pain is a debilitating, chronic condition with a significant unmet need for effective treatment options. Recent studies have demonstrated that in addition to neurons, non-neuronal cells such as microglia contribute to the initiation and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87e870c054a96fb3c306e2a07998d45c
https://pubmed.ncbi.nlm.nih.gov/27876619
https://pubmed.ncbi.nlm.nih.gov/27876619
Autor:
Gamini Chandrasena, J. John Mann, Jaya Prabhakaran, Mathivanan Packiarajan, Vrej Jubian, J. S. Dileep Kumar, Mali Pratap, Ramin V. Parsey, Mary W. Walker
Publikováno v:
ACS chemical neuroscience. 7(5)
Neuropeptide Y receptor type 5 (NPY5R) is a G-protein coupled receptor (GPCR) that belongs to the subfamily of neuropeptide receptors (NPYR) that mediate the action of endogenous neuropeptide Y (NPY). Animal models and preclinical studies indicate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5450a282121e7e2c6ba51dcc88d3df94
https://pubmed.ncbi.nlm.nih.gov/26886507
https://pubmed.ncbi.nlm.nih.gov/26886507
Autor:
Mathivanan Packiarajan, Xiaosui Pu, Robbin Brodbeck, Albert J. Robichaud, Andrew D. White, Christine G. Mazza Ferreira, Sang Phyo Hong, Gamini Chandrasena
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6469-6474
A novel series of aryl azetidinyl oxadiazoles are identified as mGluR5 positive allosteric modulators (PAMs) with improved physico-chemical properties. N-substituted cyclohexyl and exo-norbornyl carboxamides, and carbamate analogs of azetidines are m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cca7420ac50a30341308e3f70ec82c9
https://doi.org/10.1016/j.bmcl.2012.08.044
https://doi.org/10.1016/j.bmcl.2012.08.044
Autor:
Mathivanan Packiarajan, Christine G. Mazza Ferreira, Albert J. Robichaud, Xiaosui Pu, Sang Phyo Hong, Andrew D. White, Gamini Chandrasena, Robbin Brodbeck
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5658-5662
A novel series of N-aryl pyrrolidinonyl oxadiazoles were identified as mGluR5 positive allosteric modulators (PAMs). Optimization of the initial lead compound 6a led to the identification of the 12c (-) enantiomer as a potent compound with acceptable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ff5ccebe25d413f517c93d0c9a9875
https://doi.org/10.1016/j.bmcl.2012.06.094
https://doi.org/10.1016/j.bmcl.2012.06.094
Autor:
Gamini Chandrasena, Rajinder Bhardwaj
Publikováno v:
ADME-Enabling Technologies in Drug Design and Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfc7d32a821321df4737f82bbace92bb
https://doi.org/10.1002/9781118180778.ch2
https://doi.org/10.1002/9781118180778.ch2