Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs.

Autor: Weeratunga P; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Denney L; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Bull JA; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK., Repapi E; MRC WIMM Computational Biology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Sergeant M; MRC WIMM Computational Biology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Etherington R; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Vuppussetty C; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Turner GDH; Department of Cellular Pathology and Radcliffe Department of Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Clelland C; Anatomic Pathology, Weill Cornell Medical College, Doha, Qatar., Woo J; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Cross A; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Issa F; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., de Andrea CE; Navarra Institute for Health Research, Pamplona, Spain., Melero Bermejo I; Navarra Institute for Health Research, Pamplona, Spain., Sims D; MRC WIMM Computational Biology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., McGowan S; MRC WIMM Computational Biology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Zurke YX; Kennedy Institute for Rheumatology, University of Oxford, Oxford, UK., Ahern DJ; Kennedy Institute for Rheumatology, University of Oxford, Oxford, UK., Gamez EC; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Whalley J; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Richards D; Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Diseases, University of Oxford, Oxford, UK., Klenerman P; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Monaco C; Kennedy Institute for Rheumatology, University of Oxford, Oxford, UK., Udalova IA; Kennedy Institute for Rheumatology, University of Oxford, Oxford, UK., Dong T; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Antanaviciute A; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Ogg G; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Knight JC; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Byrne HM; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK.; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., Taylor S; MRC WIMM Computational Biology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. Stephen.Taylor@well.ox.ac.uk.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Stephen.Taylor@well.ox.ac.uk., Ho LP; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. Ling-pei.ho@imm.ox.ac.uk.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. Ling-pei.ho@imm.ox.ac.uk.; Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Ling-pei.ho@imm.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2023 Nov 08; Vol. 14 (1), pp. 7216. Date of Electronic Publication: 2023 Nov 08.