Zobrazeno 1 - 10
of 2 029
pro vyhledávání: '"Gametocytes"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Asexual replication of Plasmodium falciparum in the human blood results in exponential parasite growth and causes all clinical symptoms of malaria. However, at each round of the replicative cycle, some parasites convert into sexual precursor
Externí odkaz:
https://doaj.org/article/2f399a63d3d64f99bc56d6a695abd0d4
Autor:
Alphonse Ouédraogo, Julie Nguyen Ngoc Pouplin, Mavuto Mukaka, Thoopmanee Kaendiao, Andrea Ruecker, Pascal Millet, Thibaut Vallet, Fabrice Ruiz, Sodiomon B. Sirima, Walter R. Taylor
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Primaquine (PQ) has activity against mature P. falciparum gametocytes and proven transmission blocking efficacy (TBE) between humans and mosquitoes. WHO formerly recommended a single transmission blocking dose of 0.75 mg/kg but th
Externí odkaz:
https://doaj.org/article/7d4fb96f16554890974a4f67b93e5a9c
Autor:
Matthias Wyss, Basil T. Thommen, Jacob Kofler, Eilidh Carrington, Nicolas M. B. Brancucci, Till S. Voss
Publikováno v:
mSphere, Vol 9, Iss 9 (2024)
ABSTRACT Aurora kinases are crucial regulators of mitotic cell cycle progression in eukaryotes. The protozoan malaria parasite Plasmodium falciparum replicates via schizogony, a specialized mode of cell division characterized by consecutive asynchron
Externí odkaz:
https://doaj.org/article/2df59e2b4e4f4dd483515d62797913cf
Autor:
Pradeep Kumar Sheokand, Sabyasachi Pradhan, Andrew E. Maclean, Alexander Mühleip, Lilach Sheiner
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9239 (2024)
The Plasmodium falciparum mitochondrial electron transport chain (mETC) is responsible for essential metabolic pathways such as de novo pyrimidine synthesis and ATP synthesis. The mETC complex III (cytochrome bc1 complex) is responsible for transferr
Externí odkaz:
https://doaj.org/article/f405f4da43294a7da06c117f62fe1cec
Autor:
Federico Appetecchia, Emanuele Fabbrizi, Francesco Fiorentino, Sara Consalvi, Mariangela Biava, Giovanna Poce, Dante Rotili
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 962 (2024)
Malaria drug research and development efforts have resurged in the last decade following the decelerating rate of mortality and malaria cases in endemic regions. The inefficiency of malaria interventions is largely driven by the spreading resistance
Externí odkaz:
https://doaj.org/article/330d05c967854380a29d9bd9da4a8c9e
Autor:
Lorenz M. Hofer, Prisca A. Kweyamba, Rajabu M. Sayi, Mohamed S. Chabo, Sonali L. Maitra, Sarah J. Moore, Mgeni M. Tambwe
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-10 (2023)
Abstract Background Asymptomatic malaria infections (Plasmodium falciparum) are common in school-aged children and represent a disease transmission reservoir as they are potentially infectious to mosquitoes. To detect and treat such infections, conve
Externí odkaz:
https://doaj.org/article/41a9eaf47f13473b9ccc185212e6937a
Autor:
Lara Cotta Amaral, Yanka Evellyn Alves Rodrigues Salazar, Denise Anete Madureira de Alvarenga, Anielle de Pina-Costa, Ana Júlia Dutra Nunes, Júlio Cesar de Souza Junior, Gustavo Henrique Pereira Gonçalves, Zelinda Maria Braga Hirano, Sílvia Bahadian Moreira, Alcides Pissinatti, Cláudio Tadeu Daniel-Ribeiro, Taís Nóbrega de Sousa, Cristiana Ferreira Alves de Brito
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-11 (2023)
Abstract Background Plasmodium species of non-human primates (NHP) are of great interest because they can naturally infect humans. Plasmodium simium, a parasite restricted to the Brazilian Atlantic Forest, was recently shown to cause a zoonotic outbr
Externí odkaz:
https://doaj.org/article/c930b13180ff430a81184b80d7e892e8
Autor:
Ragavan Varadharajan Suresh, Bingbing Deng, Yonas Gebremicale, Kyle Roche, Kazutoyo Miura, Carole Long
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTPlasmodium falciparum is a parasite that causes the deadly human disease, malaria, and exhibits a complex life cycle in human and mosquito hosts. In the sexual stages of the parasite, gametocytes mature in the human body and propagate malaria
Externí odkaz:
https://doaj.org/article/c2a1dbe8f4c14544b3e82d666003c97b
Autor:
Jackson M. Muema, James M. Mutunga, Meshack A. Obonyo, Merid N. Getahun, Ramadhan S. Mwakubambanya, Hoseah M. Akala, Agnes C. Cheruiyot, Redemptah A. Yeda, Dennis W. Juma, Ben Andagalu, Jaree L. Johnson, Amanda L. Roth, Joel L. Bargul
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Background The unmet demand for effective malaria transmission-blocking agents targeting the transmissible stages of Plasmodium necessitates intensive discovery efforts. In this study, a bioactive bisbenzylisoquinoline (BBIQ), isoliensinine,
Externí odkaz:
https://doaj.org/article/be6482cc39094cfb87687c85f9ebef5d
Autor:
Christelle M. Ngou, Albert N. Bayibéki, Luc Abate, Olesula S. Makinde, Lionel B. Feufack-Donfack, Elangwe M. Sarah-Matio, Aline G. Bouopda-Tuedom, Paul Taconet, Nicolas Moiroux, Parfait H. Awono-Ambéné, Arthur Talman, Lawrence S. Ayong, Antoine Berry, Sandrine E. Nsango, Isabelle Morlais
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Sickle cell trait (SCT) refers to the carriage of one abnormal copy of the β-globin gene, the HbS allele. SCT offers protection against malaria, controlling parasite density and preventing progression to symptomatic malaria. Howe
Externí odkaz:
https://doaj.org/article/921c30f6ebb44504a7d7fa2af8cf1dce