Výsledky vyhledávání - "Gameel A. M. Elhagali"

Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular modeling study

Autor: Khadija E. Saadon, Nadia M. H. Taha, N. A. Mahmoud, Gameel A. M. Elhagali, Ahmed Ragab

Publikováno v: Journal of the Iranian Chemical Society. 19:3899-3917

A new series of pyridine-2-one and pyrazole derivatives were designed and synthesized based on cyanoacrylamide derivatives containing 2,4-dichlro aniline and 6-methyl 2-amino pyridine as an aryl group. Condensation of cyanoacrylamide derivatives 3a�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28bdc4e6b90b7582d654344cdfc8f2b2
https://doi.org/10.1007/s13738-022-02575-y

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A new exploration toward adamantane derivatives as potential anti-MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors

Autor: Ahmed Ragab, Moustafa S. Abusaif, Dina S. Aboul‐Magd, Mohammed M. S. Wassel, Gameel A. M. Elhagali, Yousry A. Ammar

Publikováno v: Drug development researchREFERENCES. 83(6)

Developing novel antimicrobial agents has become a necessitate due to the increasing rate of microbial resistance to antibiotics. All the newly adamantane derivatives were evaluated for their antimicrobial activities against six MDR clinical pathogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b7c8bd303fdda241df3b59d77a59f7
https://pubmed.ncbi.nlm.nih.gov/35716118

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Cu(II)-Promoted the Chemical Synthesis of New Azines-Based Naphthalene Scaffold as In Vitro Potent Mushroom Tyrosinase Inhibitors and Evaluation of Their Antiproliferative Activity

Autor: Essam M. Eliwa, Walid E. Elgammal, Amany Belal, Mohammed A. S. Abourehab, Shimaa M. Abd El-Gilil, Ahmed B. M. Mehany, Gameel A. M. Elhagali

Herein, synthesis of new designated azines-based naphthalene scaffold (3a–10) was assisted by CuCl2.2H2O for the first time. Their biological screening manifested that azines 3a, 4, 7, 9, and 10 exhibit effectual mushroom tyrosinase inhibition with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f96b85ab0c68c56d7270fdb8c9dbe73

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