Neuronal DNA Methylation Profiling of Blast-Related Traumatic Brain Injury

Autor: Stephen T. Ahlers, Gregory A. Elder, Haghighi F, Xin Y, Michelle Umali, Gama Sosa Ma, De Gasperi R, Yongchao Ge, Chen S

Long-term molecular changes in the brain resulting from blast exposure may be mediated by epigenetic changes, such as deoxyribonucleic acid (DNA) methylation, that regulate gene expression. Aberrant regulation of gene expression is associated with be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ded38f78fde96a585e57ce8330b16c1
https://europepmc.org/articles/PMC4532898/

Late-onset GM2 gangliosidosis: Ashkenazi Jewish family with an exon 5 mutation (Tyr180--His) in the Hex A alpha-chain gene

Autor: DE GASPERI, R, GAMA SOSA MA, Battistini, Stefania, Yeretsian, J, Raghavan, S, Zelnik, N, Leshinsky, E, Kolodny, Eh

Publikováno v: Neurology. 47(2)

Late-onset GM2 gangliosidosis is a variant form of Tay-Sachs disease characterized by onset of symptoms and signs in adolescence or in early adult life. The deficiency of beta-hexosaminidase A (Hex A) in this form of GM2 gangliosidosis has been invar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::75431249b2a9b179bb04fa6cd2f8b5ab
https://pubmed.ncbi.nlm.nih.gov/8757036

Exposure to Low-Intensity Blast Increases Clearance of Brain Amyloid Beta.

Autor: Abutarboush R; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Reed E; Parsons Corporation, Centreville, Virginia, USA., Chen Y; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Gu M; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Watson C; Parsons Corporation, Centreville, Virginia, USA., Kawoos U; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Statz JK; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Tschiffely AE; Department of Neurotrauma, Naval Medical Research Center, Silver Spring, Maryland, USA., Ciarlone S; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Perez-Garcia G; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA., Gama Sosa MA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; General Medical Research Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA., de Gasperi R; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Stone JR; Department of Radiology and Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia, USA., Elder GA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Mount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Neurology Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA., Ahlers ST; Department of Neurotrauma, Naval Medical Research Center, Silver Spring, Maryland, USA.

Publikováno v: Journal of neurotrauma [J Neurotrauma] 2024 Mar; Vol. 41 (5-6), pp. 685-704. Date of Electronic Publication: 2024 Jan 23.

The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma.

Autor: Elder GA; Neurology Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA.; Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029, USA.; Mount Sinai Alzheimer's Disease Research Center and the Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Gama Sosa MA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029, USA.; General Medical Research Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA., De Gasperi R; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029, USA.; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA., Perez Garcia G; Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029, USA.; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA., Perez GM; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA., Abutarboush R; Department of Neurotrauma, Operational and Undersea Medicine Directorate, Naval Medical ResearchCommand, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA., Kawoos U; Department of Neurotrauma, Operational and Undersea Medicine Directorate, Naval Medical ResearchCommand, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA., Zhu CW; Mount Sinai Alzheimer's Disease Research Center and the Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA.; Department of Geriatrics and Palliative Care, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Janssen WGM; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Stone JR; Department of Radiology and Medical Imaging, University of Virginia, 480 Ray C Hunt Drive, Charlottesville, VA 22903, USA., Hof PR; Mount Sinai Alzheimer's Disease Research Center and the Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Geriatrics and Palliative Care, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cook DG; Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.; Department of Medicine, University of Washington, 1959 NE Pacific St., Seattle, WA 98195, USA., Ahlers ST; Department of Neurotrauma, Operational and Undersea Medicine Directorate, Naval Medical ResearchCommand, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 17; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 17.

Late chronic local inflammation, synaptic alterations, vascular remodeling and arteriovenous malformations in the brains of male rats exposed to repetitive low-level blast overpressures.

Autor: Gama Sosa MA; General Medical Research Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA. miguel.gama-sosa@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA. miguel.gama-sosa@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. miguel.gama-sosa@mssm.edu., De Gasperi R; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA., Pryor D; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA., Perez Garcia GS; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA.; Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA., Perez GM; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA., Abutarboush R; Department of Neurotrauma, Operational and Undersea Medicine Directorate, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Kawoos U; Department of Neurotrauma, Operational and Undersea Medicine Directorate, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Hogg S; Micro Photonics, Inc, 1550 Pond Road, Suite 110, Allentown, PA, 18104, USA., Ache B; Micro Photonics, Inc, 1550 Pond Road, Suite 110, Allentown, PA, 18104, USA., Sowa A; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Tetreault T; MBF Bioscience LLC, 185 Allen Brook Lane, Williston, VT, 05495, USA., Varghese M; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Cook DG; Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA, 98108, USA.; Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA, 98195, USA., Zhu CW; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA.; Mount Sinai Alzheimer's Disease Research Center and the Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Tappan SJ; MBF Bioscience LLC, 185 Allen Brook Lane, Williston, VT, 05495, USA., Janssen WGM; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Hof PR; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Mount Sinai Alzheimer's Disease Research Center and the Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Geriatrics and Palliative Care, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Ahlers ST; Department of Neurotrauma, Operational and Undersea Medicine Directorate, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA., Elder GA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.; Mount Sinai Alzheimer's Disease Research Center and the Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Neurology Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2023 May 12; Vol. 11 (1), pp. 81. Date of Electronic Publication: 2023 May 12.