Azologization of serotonin 5-HT3 receptor antagonists

Autor: Karin Rustler, Galyna Maleeva, Piotr Bregestovski, Burkhard König

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 780-788 (2019)

The serotonin 5-hydroxytryptamine 3 receptor (5-HT3R) plays a unique role within the seven classes of the serotonin receptor family, as it represents the only ionotropic receptor, while the other six members are G protein-coupled receptors (GPCRs). T

Externí odkaz: https://doaj.org/article/cc476cf96b6a41858df50851f3b562f1

Orthogonal Control of Neuronal Circuits and Behavior Using Photopharmacology

Autor: Rossella Castagna, Dušan Kolarski, Romain Durand-de Cuttoli, Galyna Maleeva

Publikováno v: Journal of Molecular Neuroscience. 72:1433-1442

Over the last decades, photopharmacology has gone far beyond its proof-of-concept stage to become a bona fide approach to study neural systems in vivo. Indeed, photopharmacological control has expanded over a wide range of endogenous targets, such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7fc4462adcb451ae29a65bf84777135
https://doi.org/10.1007/s12031-022-02037-3

Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid

Autor: Galyna Maleeva, Franck Peiretti, Boris S. Zhorov, Piotr Bregestovski

Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2017)

Niflumic acid (NFA) is a member of the fenamate class of nonsteroidal anti-inflammatory drugs. This compound and its derivatives are used worldwide clinically for the relief of chronic and acute pain. NFA is also a commonly used blocker of voltage-ga

Externí odkaz: https://doaj.org/article/56220accee644122b4c246684b9b1c54

Subunit-specific photocontrol of glycine receptors by azobenzene-nitrazepam photoswitcher

Autor: Piotr Bregestovski, Daniel Wutz, Mercedes Alfonso-Prieto, Alexandre M. J. Gomila, Elena Petukhova, Daria Ponomareva, Alba Nin-Hill, Elvira Mukhametova, Galyna Maleeva, Burkhard König, Pau Gorostiza, Karin Rustler

Publikováno v: Juelich Shared Electronic Resources
Recolector de Ciencia Abierta, RECOLECTA
PubMed Central
Diposit Digital de la Universitat de Barcelona
ZENODO
UnpayWall
ORCID
Microsoft Academic Graph
eNeuro
eNeuro 8(1), ENEURO.0294-20.2020 (2021). doi:10.1523/ENEURO.0294-20.2020
Dipòsit Digital de la UB
Universidad de Barcelona

Visual Abstract
Photopharmacology is a unique approach that through a combination of photochemistry methods and advanced life science techniques allows the study and control of specific biological processes, ranging from intracellular pathways t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85157fce2e1f37520dd1f809189e5c0b
http://europepmc.org/articles/PMC7877471

Optical Control of GABA

Autor: Karin, Rustler, Galyna, Maleeva, Alexandre M J, Gomila, Pau, Gorostiza, Piotr, Bregestovski, Burkhard, König

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)

Optogenetic and photopharmacological tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biological evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd1c05a23ac3bcb5a0d37725a40453ab
https://pubmed.ncbi.nlm.nih.gov/32307732