Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms.

Autor: Pritchard JE; Institute for Cell and Tumor Biology, RWTH Aachen University Hospital, Aachen, Germany; Department of Developmental Biology, Erasmus University Medical Center, Rotterdam, the Netherlands; Oncode Institute, Erasmus University Medical Center, Rotterdam, the Netherlands., Pearce JE; Institute for Cell and Tumor Biology, RWTH Aachen University Hospital, Aachen, Germany., Snoeren IAM; Department of Developmental Biology, Erasmus University Medical Center, Rotterdam, the Netherlands; Oncode Institute, Erasmus University Medical Center, Rotterdam, the Netherlands., Fuchs SNR; Department of Developmental Biology, Erasmus University Medical Center, Rotterdam, the Netherlands; Oncode Institute, Erasmus University Medical Center, Rotterdam, the Netherlands., Götz K; Institute for Cell and Tumor Biology, RWTH Aachen University Hospital, Aachen, Germany., Peisker F; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Hospital, Aachen, Germany., Wagner S; Institute for Cell and Tumor Biology, RWTH Aachen University Hospital, Aachen, Germany., Benabid A; Institute for Cell and Tumor Biology, RWTH Aachen University Hospital, Aachen, Germany., Lutterbach N; Institute for Cell and Tumor Biology, RWTH Aachen University Hospital, Aachen, Germany., Klöker V; Institute for Computational Genomics, RWTH Aachen University Hospital, Aachen, Germany., Nagai JS; Institute for Computational Genomics, RWTH Aachen University Hospital, Aachen, Germany., Hannani MT; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Hospital, Aachen, Germany; Institute for Computational Biomedicine, Heidelberg University Hospital, Heidelberg, Germany., Galyga AK; Institute for Cell and Tumor Biology, RWTH Aachen University Hospital, Aachen, Germany., Sistemich E; Institute for Cell and Tumor Biology, RWTH Aachen University Hospital, Aachen, Germany., Banjanin B; Department of Developmental Biology, Erasmus University Medical Center, Rotterdam, the Netherlands; Oncode Institute, Erasmus University Medical Center, Rotterdam, the Netherlands., Flosdorf N; Institute for Cell and Tumor Biology, RWTH Aachen University Hospital, Aachen, Germany., Bindels E; Department of Hematology, Erasmus Medical Center, Rotterdam, the Netherlands., Olschok K; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University Hospital, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Biaesch K; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University Hospital, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Chatain N; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University Hospital, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Bhagwat N; Prelude Therapeutics, Wilmington, DE, USA., Dunbar A; Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sarkis R; Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences (DSB), Université de Lausanne (UNIL), Lausanne, Switzerland., Naveiras O; Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences (DSB), Université de Lausanne (UNIL), Lausanne, Switzerland., Berres ML; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany; Medical Department III, RWTH University Hospital Aachen, Aachen, Germany., Koschmieder S; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University Hospital, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Levine RL; Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Costa IG; Institute for Computational Genomics, RWTH Aachen University Hospital, Aachen, Germany., Gleitz HFE; Department of Developmental Biology, Erasmus University Medical Center, Rotterdam, the Netherlands; Oncode Institute, Erasmus University Medical Center, Rotterdam, the Netherlands., Kramann R; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Hospital, Aachen, Germany; Department of Internal Medicine, Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany., Schneider RK; Institute for Cell and Tumor Biology, RWTH Aachen University Hospital, Aachen, Germany; Department of Developmental Biology, Erasmus University Medical Center, Rotterdam, the Netherlands; Oncode Institute, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address: reschneider@ukaachen.de.

Publikováno v: Cell reports [Cell Rep] 2024 Jan 23; Vol. 43 (1), pp. 113608. Date of Electronic Publication: 2023 Dec 20.