Experimental colitis drives enteric alpha-synuclein accumulation and Parkinson-like brain pathology

Autor: Annika Herrmann, Remy H, Juliane Siebourg-Polster, Jennifer A. Steiner, Liz Spycher, Markus Britschgi, Markus Haenggi, Pierre Maliver, Stawiski M, Galvis Mle, Sehlhausen M, Patrik Brundin, Zachary Madaj, Stefan Grathwohl, Gonzalo Duran-Pacheco, Nazia Maroof, Andreas Wolfert, Krisztina Oroszlan-Szovik, Christoph Mueller, Thomas Emrich, Emmanuel Quansah, Benmansour F

Intraneuronal accumulation of α-synuclein (αSyn) is key in the pathogenesis of Parkinson’s disease (PD). Published studies suggest that this process begins in the enteric nervous system (ENS) and propagates into the brain decades before clinical

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Low plasma serotonin linked to higher nigral iron in Parkinson's disease.

Autor: Jellen LC; Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA., Lewis MM; Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA.; Department of Pharmacology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA., Du G; Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA., Wang X; Public Health Sciences, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA., Galvis MLE; Parkinson's Disease Center, Department of Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA., Krzyzanowski S; Parkinson's Disease Center, Department of Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA., Capan CD; Parkinson's Disease Center, Department of Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA., Snyder AM; Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA., Connor JR; Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA., Kong L; Public Health Sciences, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA., Mailman RB; Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA.; Department of Pharmacology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA., Brundin P; Parkinson's Disease Center, Department of Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA., Brundin L; Parkinson's Disease Center, Department of Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA. Lena.Brundin@vai.org.; Division of Psychiatry and Behavioral Medicine, Michigan State University College of Human Medicine, Grand Rapids, MI, USA. Lena.Brundin@vai.org., Huang X; Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA. xuemei@psu.edu.; Department of Pharmacology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA. xuemei@psu.edu.; Departments of Neurosurgery and Radiology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA. xuemei@psu.edu.; Department of Kinesiology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA. xuemei@psu.edu.; Translational Brain Research Center, Penn State University-Hershey Medical Center, 500 University Dr., Mail Code H037, Hershey, PA, 17033, USA. xuemei@psu.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Dec 21; Vol. 11 (1), pp. 24384. Date of Electronic Publication: 2021 Dec 21.