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Rapid discovery and evolution of nanosensors containing fluorogenic amino acids.

Autor: Kuru E; Department of Genetics, Harvard Medical School, Boston, MA, USA. erkin_kuru@hms.harvard.edu.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. erkin_kuru@hms.harvard.edu., Rittichier J; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; EnPlusOne Biosciences Inc., Watertown, MA, USA., de Puig H; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Flores A; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Rout S; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Han I; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Reese AE; IRR Chemistry Hub and Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Bartlett TM; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, USA., De Moliner F; IRR Chemistry Hub and Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Bernier SG; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Galpin JD; Department of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, IA, USA., Marchand J; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Chemical Engineering, University of Washington, Seattle, WA, USA., Bedell W; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Robinson-McCarthy L; Department of Genetics, Harvard Medical School, Boston, MA, USA., Ahern CA; Department of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, IA, USA., Bernhardt TG; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., Rudner DZ; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Collins JJ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Vendrell M; IRR Chemistry Hub and Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK. marc.vendrell@ed.ac.uk., Church GM; Department of Genetics, Harvard Medical School, Boston, MA, USA. gchurch@genetics.med.harvard.edu.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. gchurch@genetics.med.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 05; Vol. 15 (1), pp. 7531. Date of Electronic Publication: 2024 Sep 05.

Real-time observation of functional specialization among phosphorylation sites in CFTR.

Autor: Infield DT; Department of Molecular Physiology and Biophysics and Iowa Neuroscience Institute, University of Iowa, Carver College of Medicine , Iowa, IA, USA., Schene ME; Department of Molecular Physiology and Biophysics and Iowa Neuroscience Institute, University of Iowa, Carver College of Medicine , Iowa, IA, USA., Fazan FS; Department of Molecular Physiology and Biophysics and Iowa Neuroscience Institute, University of Iowa, Carver College of Medicine , Iowa, IA, USA., Galles GD; Department of Molecular Physiology and Biophysics and Iowa Neuroscience Institute, University of Iowa, Carver College of Medicine , Iowa, IA, USA., Galpin JD; Department of Molecular Physiology and Biophysics and Iowa Neuroscience Institute, University of Iowa, Carver College of Medicine , Iowa, IA, USA., Ahern CA; Department of Molecular Physiology and Biophysics and Iowa Neuroscience Institute, University of Iowa, Carver College of Medicine , Iowa, IA, USA.

Publikováno v: The Journal of general physiology [J Gen Physiol] 2023 Apr 03; Vol. 155 (4). Date of Electronic Publication: 2023 Jan 25.

Tuning phenylalanine fluorination to assess aromatic contributions to protein function and stability in cells.

Autor: Galles GD; Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA, USA.; The GCE4All Research Center, Department of Biochemistry & Biophysics, Oregon State University, Corvallis, OR, USA., Infield DT; Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA, USA., Clark CJ; Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA, USA., Hemshorn ML; The GCE4All Research Center, Department of Biochemistry & Biophysics, Oregon State University, Corvallis, OR, USA., Manikandan S; Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA, USA., Fazan F; Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA, USA., Rasouli A; Theoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Tajkhorshid E; Theoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Galpin JD; Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA, USA., Cooley RB; The GCE4All Research Center, Department of Biochemistry & Biophysics, Oregon State University, Corvallis, OR, USA., Mehl RA; The GCE4All Research Center, Department of Biochemistry & Biophysics, Oregon State University, Corvallis, OR, USA., Ahern CA; Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA, USA. christopher-ahern@uiowa.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jan 04; Vol. 14 (1), pp. 59. Date of Electronic Publication: 2023 Jan 04.