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Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects.

Autor: Menachem A; Preclinical Development, Compugen Ltd., Holon, Israel., Alteber Z; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Cojocaru G; Computational Discovery, Compugen Ltd., Holon, Israel., Fridman Kfir T; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Blat D; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Leiderman O; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Galperin M; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Sever L; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Cohen N; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Cohen K; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Granit RZ; Computational Discovery, Compugen Ltd., Holon, Israel., Vols S; Computational Discovery, Compugen Ltd., Holon, Israel., Frenkel M; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Soffer L; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Meyer K; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Menachem K; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Galon Tilleman H; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Morein D; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Borukhov I; Computational Discovery, Compugen Ltd., Holon, Israel., Toporik A; Computational Discovery, Compugen Ltd., Holon, Israel., Perpinial Shahor M; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Tatirovsky E; Research & Drug Discovery, Compugen Ltd., Holon, Israel., Mizrachi A; Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Levy-Barda A; Biobank, Department of pathology, Rabin Medical Center, Petah Tikva, Israel., Sadot E; Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.; Department of Surgery, Rabin Medical Center, Petach Tikva, Israel., Strenov Y; Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.; Department of Pathology, Rabin Medical Center, Petah Tikva, Israel., Eitan R; Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel., Jakobson-Setton A; Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel., Yanichkin N; Department of Pathology, Rabin Medical Center, Petah Tikva, Israel., Ferre P; Preclinical Development, Compugen Ltd., Toulouse, France., Ophir E; Compugen Ltd., Holon, Israel.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2024 Jun 04; Vol. 12 (6), pp. 687-703.