Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Galloway WRJD"'
Publikováno v:
Angewandte Chemie (International Ed. in English)
Synthetic macrocycles are an attractive area in drug discovery. However, their use has been hindered by a lack of versatile platforms for the generation of structurally (and thus shape) diverse macrocycle libraries. Herein, we describe a new concept
Publikováno v:
European Journal of Organic Chemistry
The synthesis of four quinolone natural products from the actinomycete Pseudonocardia sp. is reported. The key step involved a sp2–sp3 Suzuki–Miyaura reaction between a common boronic ester lateral chain and various functionalised quinolone cores
Flavonoids are a large family of compounds associated with a broad range of biologically useful properties. In recent years, synthetic compounds that contain two flavonoid units linked together have attracted attention in drug discovery and developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::d806ec96640655abe7563c4995d105c3
https://www.repository.cam.ac.uk/handle/1810/261202
https://www.repository.cam.ac.uk/handle/1810/261202
Fragment-based lead generation has proven to be an effective means of identifying high-quality lead compounds for drug discovery programs. However, the fragment screening sets often used are principally comprised of sp²-rich aromatic compounds, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::ee9d479442e70febd1eed82ac511f77a
https://www.repository.cam.ac.uk/handle/1810/260773
https://www.repository.cam.ac.uk/handle/1810/260773
Pyrido[1,2-a]pyrimidin-2-ones represent a pharmaceutically interesting class of heterocycles. The structurally related pyrido[1,2-a]pyrimidin-4-ones are associated with a broad range of useful biological properties. Furthermore, quinolizinone-type sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::0bab6f27d7d54d8381e1682d9190696c
https://www.repository.cam.ac.uk/handle/1810/253003
https://www.repository.cam.ac.uk/handle/1810/253003
The concise and step-economical total syntheses of three hydroxyaurones and one polymethoxyflavone from readily available starting materials is described. A divergent synthetic strategy is employed, which centres on a common chalcone scaffold from wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::4accee5ee68e9187a663f4093389cec0
https://www.repository.cam.ac.uk/handle/1810/254692
https://www.repository.cam.ac.uk/handle/1810/254692
Publikováno v:
Tetrahedron. (25):3567-3578
Naturally-derived macrocyclic compounds are associated with a diverse range of biological activities, including antibacterial effects, and there are over 100 marketed macrocycle drugs derived from natural products. However, synthetic macrocycles are
Flavonoids are a large family of compounds associated with a broad range of biologically useful properties. In recent years, synthetic compounds that contain two flavonoid units linked together have attracted attention in drug discovery and developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b25a43a517545985d7ef3f911807580b
Fragment-based lead generation has proven to be an effective means of identifying high-quality lead compounds for drug discovery programs. However, the fragment screening sets often used are principally comprised of sp²-rich aromatic compounds, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef01195164426b801e5993accba6a25c
Autor:
Morkunas, B, Gal, B, Galloway, WRJD, Hodgkinson, JT, Ibbeson, BM, Tan, YS, Welch, M, Spring, DR
Pyocyanin is a small molecule produced by Pseudomonas aeruginosa that plays a crucial role in the pathogenesis of infections by this notorious opportunistic pathogen. The inhibition of pyocyanin production has been identified as an attractive antivir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bea43b942359069e352e3bda43da521