STING agonist-containing microparticles improve seasonal influenza vaccine efficacy and durability in ferrets over standard adjuvant.

Autor: Gallovic MD; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Junkins RD; Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Sandor AM; Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Pena ES; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Sample CJ; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA., Mason AK; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA., Arwood LC; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA., Sahm RA; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA., Bachelder EM; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Ainslie KM; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, USA., Sempowski GD; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA., Ting JP; Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Institute for Inflammatory Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: jenny_ting@med.unc.edu.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2022 Jul; Vol. 347, pp. 356-368. Date of Electronic Publication: 2022 May 18.

STING Agonist Mitigates Experimental Autoimmune Encephalomyelitis by Stimulating Type I IFN-Dependent and -Independent Immune-Regulatory Pathways.

Autor: Johnson BM; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Uchimura T; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Gallovic MD; Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Thamilarasan M; Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Chou WC; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Gibson SA; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Deng M; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Oral and Craniofacial Biomedicine Program, School of Dentistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Tam JW; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Batty CJ; Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Williams J; Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Matsushima GK; Neuroscience Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Bachelder EM; Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Ainslie KM; Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Markovic-Plese S; Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Ting JP; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC; jenny_ting@med.unc.edu.; Neuroscience Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Center for Translational Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC; and.; Institute for Inflammatory Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 May 01; Vol. 206 (9), pp. 2015-2028. Date of Electronic Publication: 2021 Apr 05.

Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications.

Autor: Islam S; Department of Physiology, Sylhet Agricultural University, Sylhet, 3100, Bangladesh., Islam MM; Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, 3100, Bangladesh., Akhand MRN; Department of Biochemistry and Chemistry, Sylhet Agricultural University, Sylhet, 3100, Bangladesh., Park BY; Institute of Animal Transplantation, College of Veterinary Medicine, Jeonbuk National University, Iksan, 54596, South Korea., Akanda MR; Department of Pharmacology and Toxicology, Sylhet Agricultural University, Sylhet, 3100, Bangladesh. akandamr.dph@sau.ac.bd.

Publikováno v: Medical oncology (Northwood, London, England) [Med Oncol] 2024 Oct 18; Vol. 41 (11), pp. 291. Date of Electronic Publication: 2024 Oct 18.

A microparticle platform for STING-targeted immunotherapy enhances natural killer cell- and CD8 ⁺ T cell-mediated anti-tumor immunity.

Autor: Watkins-Schulz R; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Tiet P; Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina, Chapel Hill, NC, 27599, USA., Gallovic MD; Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina, Chapel Hill, NC, 27599, USA., Junkins RD; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Batty C; Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina, Chapel Hill, NC, 27599, USA., Bachelder EM; Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina, Chapel Hill, NC, 27599, USA., Ainslie KM; Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina, Chapel Hill, NC, 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Ting JPY; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Institute for Inflammatory Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address: jenny_ting@med.unc.edu.

Publikováno v: Biomaterials [Biomaterials] 2019 Jun; Vol. 205, pp. 94-105. Date of Electronic Publication: 2019 Mar 14.

Injectable long-acting human immunodeficiency virus antiretroviral prodrugs with improved pharmacokinetic profiles.

Autor: Krovi SA; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA., Gallovic MD; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA., Keller AM; Department of Microbiology, Ohio State University, Columbus, OH 43210, USA., Bhat M; Department of Microbiology, Ohio State University, Columbus, OH 43210, USA., Tiet P; United Therapeutics, Durham, NC 27709, USA., Chen N; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA., Collier MA; Avanti Polar Lipids, Alabaster, AL 35007, USA., Gurysh EG; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA., Pino EN; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA., Johnson MM; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA., Shamim Hasan Zahid M; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA., Cottrell ML; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA., Pirone JR; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA., Kashuba AD; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA., Kwiek JJ; Department of Microbiology, Ohio State University, Columbus, OH 43210, USA., Bachelder EM; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA., Ainslie KM; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA. Electronic address: ainsliek@email.unc.edu.

Publikováno v: International journal of pharmaceutics [Int J Pharm] 2018 Dec 01; Vol. 552 (1-2), pp. 371-377. Date of Electronic Publication: 2018 Oct 08.