Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants.

Autor: Plouffe B; Department of Biochemistry and Molecular Medicine, Université de Montréal, H3T 1J4 Montréal, Québec, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, H3T 1J4 Montréal, Québec, Canada.; The Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, BT9 7BL Belfast, U.K., Karamitri A; Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France., Flock T; Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.; Department of Biology, ETH Zürich, 8093 Zürich, Switzerland., Gallion JM; Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, 77030 Houston, Texas, United States., Houston S; The Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, BT9 7BL Belfast, U.K., Daly CA; The Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, BT9 7BL Belfast, U.K., Bonnefond A; Université de Lille, INSERM/CNRS UMR 1283/8199-EGID, Institut Pasteur de Lille, CHU de Lille, 59045 Lille, France., Guillaume JL; Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France., Le Gouill C; Institute for Research in Immunology and Cancer, Université de Montréal, H3T 1J4 Montréal, Québec, Canada., Froguel P; Université de Lille, INSERM/CNRS UMR 1283/8199-EGID, Institut Pasteur de Lille, CHU de Lille, 59045 Lille, France., Lichtarge O; Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, 77030 Houston, Texas, United States.; Department of Molecular and Human Genetics, Baylor College of Medicine, 77030 Houston, Texas, United States., Deupi X; Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.; Condensed Matter Theory Group, Division of Scientific Computing, Theory, and Data, Paul Scherrer Institute, 5232 Villigen, Switzerland., Jockers R; Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France., Bouvier M; Department of Biochemistry and Molecular Medicine, Université de Montréal, H3T 1J4 Montréal, Québec, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, H3T 1J4 Montréal, Québec, Canada.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2022 Jan 25; Vol. 5 (2), pp. 89-101. Date of Electronic Publication: 2022 Jan 25 (Print Publication: 2022).