Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial.

Autor: Monti G; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Bradic N; Clinical Department of Anesthesiology, Resuscitation and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia.; University North, Varazdin, Croatia., Marzaroli M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Konkayev A; National Scientific Center of Traumatology and Orthopedia named acad NBatpenov, Astana Medical University, Astana, Kazakhstan., Fominskiy E; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Kotani Y; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Kameda Medical Center, Kamogawa, Japan., Likhvantsev VV; V. Negovsky Reanimatology Research Institute, Moscow, Russia., Momesso E; UOC Anestesia Rianimazione Ospedale San Donà di Piave, San Donà di Piave, Italy., Nogtev P; I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia., Lobreglio R; Department of Anesthesia, Intensive Care and Emergency, Citta della Salute e della Scienza University Hospital, Turin, Italy., Redkin I; Federal Research and Clinical Center of Resuscitation and Rehabilitation, Moscow, Russia., Toffoletto F; UOC Anestesia Rianimazione Ospedale San Donà di Piave, San Donà di Piave, Italy., Bruni A; Anesthesia and Intensive Care, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Baiardo Redaelli M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., D'Andrea N; Department of Anesthesia and Intensive Care Medicine, ASUFC University Hospital of Udine, Udine, Italy., Paternoster G; Azienda Ospedaliera Regionale San Carlo, Potenza, Italy., Scandroglio AM; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Gallicchio F; Azienda Ospedaliera Regionale San Carlo, Potenza, Italy., Ballestra M; Rianimazione Ospedali Galliera, Genova, Italy., Calabrò MG; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Cotoia A; University Hospital Policlinico of Foggia, Foggia, Italy., Perone R; Department of Cardio Thoracic and Vascular Surgery, Pineta Grande Hospital, Pineta Grande, Italy., Cuffaro R; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Montrucchio G; Department of Anesthesia, Intensive Care and Emergency, Citta della Salute e della Scienza University Hospital, Turin, Italy.; Department of Surgical Sciences, University of Turin, Turin, Italy., Pota V; Università della Campania L. Vanvitelli, Napoli, Italy., Ananiadou S; Anestesia e Rianimazione ASST Cremona, Cremona, Italy., Lembo R; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Musu M; Dipartimento di Scienze Mediche e Sanità Pubblica, Università degli Studi di Cagliari, Cagliari, Italy.; Azienda Ospedaliero Universitaria di Cagliari, Cagliari, Italy., Rauch S; Department of Anaesthesiology and Intensive Care Medicine, Hospital of Merano, Merano, Italy., Galbiati C; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Pinelli F; Azienda Ospedaliera Universitaria Careggi, Florence, Italy., Pasin L; Azienda Ospedale Università Padova, Padua, Italy., Guarracino F; Dipartimento Anestesia e Rianimazione, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy., Santarpino G; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.; GVM Care and Research, Department of Cardiac Surgery, Città di Lecce Hospital, Lecce, Italy.; Department of Cardiac Surgery, Paracelsus Medical University, Nuremberg, Germany., Agrò FE; Research Unit of Anesthesia and Intensive Care, Department of Medicine and Surgery, Università Campus Bio-Medico, Rome, Italy.; Operative Research Unit of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Bove T; Department of Anesthesia and Intensive Care Medicine, ASUFC University Hospital of Udine, Udine, Italy.; Department of Medicine, University of Udine, Udine, Italy., Corradi F; Department of Surgical, Medical, Molecular Pathology, and Critical Care Medicine, University of Pisa, Pisa, Italy., Forfori F; Department of Surgical, Medical, Molecular Pathology, and Critical Care Medicine, University of Pisa, Pisa, Italy., Longhini F; Anesthesia and Intensive Care, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Cecconi M; Department of Biomedical Sciences, Humanitas University Pieve Emanuele, Milan, Italy.; Department of Anaesthesia and Intensive Care, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Landoni G; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Bellomo R; Department of Critical Care, University of Melbourne, Melbourne, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia., Zangrillo A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.

Publikováno v: JAMA [JAMA] 2023 Jul 11; Vol. 330 (2), pp. 141-151.