Structure-affinity relationship studies on arylpiperazine derivatives related to quizapine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT3 receptor

Autor: Cappelli A. 1, Giuliani G. 1, Gallelli A. 1, Valenti S. 1, Anzini M. 1, Mennuni L. 2, Makovec F. 2, Cupello A. 3, Vomero S. 1

Publikováno v: Bioorganic & medicinal chemistry
13 (2005): 3455–3460.
info:cnr-pdr/source/autori:Cappelli A. 1, Giuliani G. 1, Gallelli A. 1, Valenti S. 1, Anzini M. 1, Mennuni L. 2, Makovec F. 2, Cupello A. 3, Vomero S. 1/titolo:Structure-affinity relationship studies on arylpiperazine derivatives related to quizapine as serotonin transporter ligands. Molecular basis of the selectivity SERT%2F5HT3 receptor/doi:/rivista:Bioorganic & medicinal chemistry (Print)/anno:2005/pagina_da:3455/pagina_a:3460/intervallo_pagine:3455–3460/volume:13

A series of quipazine derivatives, previously synthesized to probe the 5-HT(3) receptor, was evaluated for its potential interaction with serotonin transporter (SERT). Some of them show nanomolar affinity for the rodent SERT comparable to or slightly

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http://www.cnr.it/prodotto/i/10153