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Akademický článek
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Mammary tumor organoids have become a promising in vitro model for drug screening and personalized medicine. However, the dependency on the basement membrane extract (BME) as the growth matrices limits their comprehensive application. In this work, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::5b2a5a8dcedb78968c5491b30d86e2a7
https://hdl.handle.net/10453/154349
https://hdl.handle.net/10453/154349
Autor:
Mayer, JU, Hilligan, KL, Chandler, JS, Eccles, DA, Old, SI, Domingues, RG, Yang, J, Webb, GR, Munoz-Erazo, L, Hyde, EJ, Wakelin, KA, Tang, S-C, Chappell, SC, von Daake, S, Brombacher, F, Mackay, CR, Sher, A, Tussiwand, R, Connor, LM, Gallego-Ortega, D, Jankovic, D, Le Gros, G, Hepworth, MR, Lamiable, O, Ronchese, F
The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of CD11blo migratory DC2s-a DC2 population unique to the dermis-required IL-13 signaling depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::a14b4bc3684d6ce9b52b24f4aebbeeb3
https://hdl.handle.net/10453/156211
https://hdl.handle.net/10453/156211
In the past few years, the rapid development of single-cell analysis techniques has allowed for increasingly in-depth analysis of DNA, RNA, protein, and epigenetic states, at the level of the individual cell. This unprecedented characterization abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::d3f9baea55401f11e2a611dc4b222c58
https://hdl.handle.net/10453/144676
https://hdl.handle.net/10453/144676
The intact vaginal epithelium is essential for women's reproductive health and provides protection against HIV and sexually transmitted infections. How this epithelium maintains itself remains poorly understood. Here, we used single-cell RNA sequenci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::2d495ca81a7cc554cfdef4f5d2bf8ae0
https://hdl.handle.net/10453/143828
https://hdl.handle.net/10453/143828
Multicellular tumor spheroids are attracting more attention as a physiologically relevant in vitro tumor model for biomedical research. The size of spheroids is one of the critical parameters related to drug penetration and cellular responses. It rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::7ff167b0e565ae5c37f8aa67b5c31282
https://hdl.handle.net/10453/140792
https://hdl.handle.net/10453/140792
Autor:
Piggin CL, Roden DL, Law AMK, Molloy MP, Krisp C, Swarbrick A, Naylor MJ, Kalyuga M, Kaplan W, Oakes SR, Gallego-Ortega D, Clark SJ, Carroll JS, Bartonicek N, Ormandy CJ
Acquired resistance to endocrine therapy is responsible for half of the therapeutic failures in the treatment of breast cancer. Recent findings have implicated increased expression of the ETS transcription factor ELF5 as a potential modulator of estr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::ef7b9c365267aa533a870a9ad19e6c61
https://hdl.handle.net/10453/144195
https://hdl.handle.net/10453/144195
Autor:
Castillo L, Young AIJ, Mawson A, Schafranek P, Steinmann AM, Nessem D, Parkin A, Johns A, Chou A, Law AMK, Lucas MC, Murphy KJ, Deng N, Gallego-Ortega D, Caldon CE, Australian Pancreatic Cancer Genome Initiative (APGI), Timpson P, Pajic M, Ormandy CJ, Oakes SR
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies. It is phenotypically heterogeneous with a highly unstable genome and provides few common therapeutic targets. We found that MCL1, Cofilin1 (CFL1) and SRC mRNA were hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::6c1e7aebf93256bc3fd0ad16986ca325
https://hdl.handle.net/10453/144833
https://hdl.handle.net/10453/144833