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A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.

Autor: Baragi VM, Becher G, Bendele AM, Biesinger R, Bluhm H, Boer J, Deng H, Dodd R, Essers M, Feuerstein T, Gallagher BM Jr, Gege C, Hochgürtel M, Hofmann M, Jaworski A, Jin L, Kiely A, Korniski B, Kroth H, Nix D

Publikováno v: Arthritis & Rheumatism; Jul2009, Vol. 60 Issue 7, p2008-2018, 11p

US immigration order strikes against biotech.

Autor: Levin JM; Ovid Therapeutics, New York, New York, USA., Holtzman SH; Decibel Therapeutics, Cambridge, Massachusetts, USA., Maraganore J; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., Hastings PJ; OncoMed Pharmaceuticals, Redwood City, California, USA., Cohen R; Acorda Therapeutics, Inc., Ardsley, New York, USA., Dahiyat B; Xencor, Monrovia, California, USA., Adams J; Clal Biotechnology Industries (CBI), Cambridge, Massachusetts, USA., Adams C; Cydan Development Inc., Cambridge, Massachusetts, USA., Ahrens B; Canaan Partners, Menlo Park, California, USA., Albers J; Blueprint Medicines, Cambridge, Massachusetts, USA., Aspinall MG; Health Catalysts, Tucson, Arizona, USA., Audia JE; Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts, USA., Babler M; Principia Biopharma, South San Francisco, California, USA., Barrett P; Atlas Venture, Cambridge, Massachusetts, USA., Barry Z; ZappRx, Boston, Massachusetts, USA., Bermingham N; Intellia Therapeutics, Cambridge, Massachusetts, USA., Bloch S; Canaan Partners, Westport, Connecticut, USA., Blum RI; Cytokinetics, Inc., South San Francisco, California, USA., Bolno PB; Wave Life Sciences, Cambridge, Massachusetts, USA., Bonney MW; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., Booth B; Atlas Venture, Cambridge, Massachusetts, USA., Bradbury DM; Amylin Pharmaceuticals, San Diego, California, USA., Brauer SK; Salus Discovery LLC, San Diego, California, USA., Byers B; Biotech Venture Capitalist since 1978, Menlo Park, California, USA., Cagnoni PJ; Tizona Therapeutics, Inc., South San Francisco, California, USA., Cali BM; Ironwood Pharmaceuticals, Cambridge, Massachusetts, USA., Ciechanover I; Atara Bio, South San Francisco, California, USA., Clark C; Genocea Biosciences, Inc., Cambridge, Massachusetts, USA., Clayman MD; Flexion Therapeutics, Burlington, Massachusetts, USA., Cleland JL; Graybug Vision, Redwood City, California, USA., Cobb P; Decibel Therapeutics, Cambridge, Massachusetts, USA., Cooper R; Albireo Pharma Inc., Boston, Massachusetts, USA., Currie MG; Ironwood Pharmaceuticals, Cambridge, Massachusetts, USA., Diekman J; 5AM Ventures, Boston, Massachusetts, USA., Dobmeier EL; Seattle Genetics, Bothell, Washington, USA., Doerfler D; MaxCyte, Inc., Gaithersburg, Maryland, USA., Donley EL; NeuroPoint Dx, Madison, Wisconsin, USA., Dunsire D; Southern Cross Biotech Consulting, Waltham, Massachusetts, USA., During M; Ovid Therapeutics, New York, New York, USA., Eckstein JW; SR One, Conshohocken, Pennsylvania, USA., Elenko E; PureTech Health, Boston, Massachusetts, USA., Exter NA; Third Rock Ventures, Boston, Massachusetts, USA., Fleming JJ; Q-State Biosciences, Cambridge, Massachusetts, USA., Flesher GJ; OticPharma Inc., Irvine, California, USA., Formela JF; Atlas Venture, Cambridge, Massachusetts, USA., Forrester R; Verastem Inc., Needham, Massachusetts, USA., Francois C; Apellis Pharmaceuticals, Crestwood, Kentucky, USA., Franklin H; Blaze Bioscience Inc., Seattle, Washington, USA., Freeman MW; 5AM Ventures, Boston, Massachusetts, USA., Furst H; Deerfield Management, New York, New York, USA., Gage LP; Tetraphase, Watertown, Massachusetts, USA., Galakatos N; Clarus, Cambridge, Massachusetts, USA., Gallagher BM; SR One, Ltd., Cambridge, Massachusetts, USA., Geraghty JA; Juniper Pharmaceuticals, Boston, Massachusetts, USA., Gill S; Evelo Biosciences, Cambridge, Massachusetts, USA., Goeddel DV; The Column Group, San Francisco, California, USA., Goldsmith MA; Revolution Medicines, Inc., Redwood City, California, USA., Gowen M; Trevena Inc., King of Prussia, Pennsylvania, USA., Goyal V; SR One, Ltd., Cambridge, Massachusetts, USA., Graney T; Ironwood Pharmaceuticals, Cambridge, Massachusetts, USA., Grayzel D; Atlas Venture, Cambridge, Massachusetts, USA., Greene B; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., Grint P; Regulus Therapeutics, San Diego, California, USA., Gutierrez-Ramos JC; Synlogic, Cambridge, Massachusetts, USA., Haney B; Dragonfly Therapeutics, Inc., Cambridge, Massachusetts, USA., Ha-Ngoc T; KEW, Inc., Cambridge, Massachusetts, USA., Harris T; SV Life Sciences, Boston, Massachusetts, USA., Hasnain F; FSG Biotech, San Diego, California, USA., Hata YS; IDEAYA Biosciences, South San Francisco, California, USA., Hecht P; Ironwood Pharmaceuticals, Cambridge, Massachusetts, USA., Henshaw L; Deerfield Management, New York, New York, USA., Heyman R; Metacrine, Inc., San Diego, California, USA., Hoppenot H; Incyte, Wilmington, Delaware, USA., Horvitz HR; Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Hughes TE; Zafgen, Inc., Boston, Massachusetts, USA., Hutton WS; Canaan Partners, Menlo Park, California, USA., Isaacs ST; Aduro Biotech, Berkley, California, USA., Jenkins A; Dimension Therapeutics, Cambridge, Massachusetts, USA., Jonker J; NGM Biopharmaceuticals, Inc., South San Francisco, California, USA., Kaplan J; Deerfield Management, New York, New York, USA., Karsen P; Intellia Therapeutics, Cambridge, Massachusetts, USA., Keiper J; Nimbus Therapeutics, Cambridge, Massachusetts, USA., Kim J; Deerfield Management, New York, New York, USA., Kindler J; Centrexion Therapeutics Inc., Boston, Massachusetts, USA., King R; GlycoMimetics, Inc., Rockville, Maryland, USA., King V; Luc Therapeutics, Inc., Cambridge, Massachusetts, USA., Kjellson N; Canaan Partners, Menlo Park, California, USA., Koenig S; MacroGenics, Inc., Rockville, Maryland, USA., Koenig G; Quartet Medicine, Cambridge, Massachusetts, USA., Kolchinsky P; RA Capital Management, LLC, Boston, Massachusetts, USA., Laikind P; ViaCyte, Inc., San Diego, California, USA., Langer RB; Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Lee JJ; Decibel Therapeutics, Cambridge, Massachusetts, USA., Leff JS; Deerfield Management, New York, New York, USA., Leicher BA; Momenta Pharmaceuticals, Inc., Cambridge, Massachusetts, USA., Leschly N; Bluebird Bio, Cambridge, Massachusetts, USA., Levin A; RA Capital Management, LLC, Boston, Massachusetts, USA., Levin M; Third Rock Ventures, Boston, Massachusetts, USA., Levine AJ; Institute for Advanced Study, Princeton, New Jersey, USA., Levy A; Chrono Therapeutics, Hayward, California, USA., Liu DR; Editas Medicine, Cambridge, Massachusetts, USA., Lodish HF; Whitehead Institute MIT, Cambridge, Massachusetts, USA., Lopatin U; Assembly Biosciences, Carmel, Indiana, USA., Love TW; Global Blood Therapeutics, South San Francisco, California, USA., Macdonald G; Tetraphase, Watertown, Massachusetts, USA., Maderis GJ; Antiva Biosciences, Inc., South San Francisco, California, USA., Mahadevia A; Spero Therapeutics, Cambridge, Massachusetts, USA., Mahanthappa NK; Scholar Rock, Cambridge, Massachusetts, USA., Martin JF; Dauntless Pharmaceuticals, Inc., San Diego, California, USA., Martin A; Realm Therapeutics, Malvern, Pennsylvania, USA., Martucci WE; Akili Interactive, Boston, Massachusetts, USA., McArthur JG; Imara, Cambridge, Massachusetts, USA., McCann CM; Pear Therapeutics, Boston, Massachusetts, USA., McCarthy SA; CytomX, South San Francisco, California, USA., McDonough CG; Sobi, Waltham, Massachusetts, USA., Mendlein J; aTyr Pharma, San Diego, California, USA., Miller L; Macrolide Pharmaceuticals, Watertown, Massachusetts, USA., Miralles D; Adaptive Biotechnologies, Seattle, Washington, USA., Moch KI; Cognition Therapeutics, Inc., Pittsburgh, Pennsylvania, USA., More B; Alta Partners, San Francisco, California, USA., Myers AG; Harvard University, Cambridge, Massachusetts, USA., Narachi MA; Orexigen Therapeutics, La Jolla, California, USA., Nashat A; Polaris Partners, Boston, Massachusetts, USA., Nelson W; Boston Biotech Forum, Cambridge, Massachusetts, USA., Newell WJ; Sutro Biopharma, Inc., South San Francisco, California, USA., Olle B; Vedanta Biosciences, Inc., Cambridge, Massachusetts, USA., Osborn JE; Egalet, Wayne, Pennsylvania, USA., Owens JC; Millendo Therapeutics, Inc., Ann Arbor, Michigan, USA., Pande A; Verity BioConsulting, San Diego, California, USA., Papadopoulos S; Biogen Inc., Exelixis Inc. &Regulus Therapeutics Inc., Great Neck, New York, USA., Parker HS; Parker BioConsulting, Seattle, Washington, USA., Parmar KM; 5AM Ventures, Boston, Massachusetts, USA., Patterson MR; Audentes Therapeutics, Inc., San Francisco, California, USA., Paul SM; Voyager Therapeutics, Inc., Cambridge, Massachusetts, USA., Perez R; Life Science Cares, Boston, Massachusetts, USA., Perry M; BVF Partners, LP, San Francisco, California, USA., Pfeffer CG; Third Rock Ventures, Boston, Massachusetts, USA., Powell M; Sofinnova Ventures, Menlo Park, California, USA., Pruzanski M; Intercept Pharma, New York, New York, USA., Purcell DJ; Aisling Capital, New York, New York, USA., Rakhit A; Ovid Therapeutics, New York, New York, USA., Ramamoorthi K; Encoded Genomics, South San Francisco, California, USA., Rastetter W; Neurocrine Biosciences Inc., San Diego, California, USA., Rawcliffe AA; Adaptimmune, Philadelphia, Pennsylvania, USA., Reid LE; Warp Drive Bio, Cambridge, Massachusetts, USA., Renaud RC; RaNa Therapeutics, Cambridge, Massachusetts, USA., Rhodes JP; Atlas Venture, Cambridge, Massachusetts, USA., Rieflin WJ; NGM Biopharmaceuticals, Inc., South San Francisco, California, USA., Robins C; Adaptive Biotechnologies, Seattle, Washington, USA., Rocklage SM; 5AM Ventures, San Francisco, California, USA., Rosenblatt M; Flagship Pioneering, Cambridge, Massachusetts, USA., Rosin JG; Ironwood Pharmaceuticals, Cambridge, Massachusetts, USA., Rutter WJ; Synergenics, LLC, San Francisco, California, USA., Saha S; Delinia, Cambridge, Massachusetts, USA., Samuels C; Venrock, Palo Alto, California, USA., Sato VL; Harvard Business School, Cambridge, Massachusetts, USA., Scangos G; Vir Bio, San Francisco, California, USA., Scarlett JA; Geron Corporation, Menlo Park, California, USA., Schenkein D; Agios, Cambridge, Massachusetts, USA., Schreiber SL; Broad Institute, Cambridge, Massachusetts, USA., Schwab A; 5AM Ventures, San Francisco, California, USA., Sekhri P; Lycera Corporation, New York, New York, USA., Shah R; RA Capital Management, LLC, Boston, Massachusetts, USA., Shenk T; Lewis Thomas Laboratory, Princeton, New Jersey, USA., Siegall CB; Seattle Genetics, Bothell, Washington, USA., Simon NJ; Clarus Ventures LLC, South San Francisco, California, USA., Simonian N; Syros Pharmaceuticals, Cambridge, Massachusetts, USA., Stein J; Cidara Therapeutics, San Diego, California, USA., Su M; Decibel Therapeutics, Cambridge, Massachusetts, USA., Szela MT; Novelion Therapeutics, Vancouver, British Columbia, USA., Taglietti M; SCYNEXIS, Inc., Jersey City, New Jersey, USA., Tandon N; EpiBone, Inc., New York, New York, USA., Termeer H; Genzyme Corporation (former CEO), Cambridge, Massachusetts, USA., Thornberry NA; Kallyope, New York, New York, USA., Tolar M; Alzheon, Framingham, Massachusetts, USA., Ulevitch R; 5AM Ventures, La Jolla, California, USA., Vaishnaw AK; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA., VanLent A; AMV Advisors, Princeton, New Jersey, USA., Varsavsky M; Prelude Fertility, Inc., Atlanta, Georgia, USA., Vlasuk GP; Navitor Pharmaceuticals, Inc., Cambridge, Massachusetts, USA., Vounatsos M; Biogen, Cambridge, Massachusetts, USA., Waksal SG; MeiraGTx, New York, New York, USA., Warma N; Opexa Therapeutics, Inc., The Woodlands, Texas, USA., Watts RJ; Denali Therapeutics Inc., South San Francisco, California, USA., Werber Y; Ovid Therapeutics, New York, New York, USA., Westphal C; Flex Pharma, Boston, Massachusetts, USA., Wierenga W; Crinetics Pharmaceuticals, San Diego, California, USA., Williams DE; Codiak BioSciences, Cambridge, Massachusetts, USA., Williams LR; Five Prime Therapeutics, Inc., South San Francisco, California, USA., Xanthopoulos KG; Cerus, La Jolla, California, USA., Zohar D; PureTech Health, Boston, Massachusetts, USA., Zweifach SS; Nuvelution Pharmaceuticals, Inc., South San Francisco, California, USA.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2017 Mar 07; Vol. 35 (3), pp. 204-206.

In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent.

Autor: Liu J; Eisai Research Institute, 4 Corporate Drive, Andover, MA 01810, USA., Towle MJ, Cheng H, Saxton P, Reardon C, Wu J, Murphy EA, Kuznetsov G, Johannes CW, Tremblay MR, Zhao H, Pesant M, Fang FG, Vermeulen MW, Gallagher BM Jr, Littlefield BA

Publikováno v: Anticancer research [Anticancer Res] 2007 May-Jun; Vol. 27 (3B), pp. 1509-18.

Microtubule-stabilizing natural products as promising cancer therapeutics.

Autor: Gallagher BM Jr; Alantos Pharmaceuticals, Inc., Cambridge, MA 02139, USA. bmgallagherjr@hotmail.com

Publikováno v: Current medicinal chemistry [Curr Med Chem] 2007; Vol. 14 (28), pp. 2959-67.